Saratov JOURNAL of Medical and Scientific Research

Kaplanova T.l.

Saratov State Medical University n. a. V. I. Razumovsky, Associate Professor of Department of Therapy with Courses of Cardiology, Functional Diagnostics and Geriatrics, Associate Professor, PhD

Terahertz therapy at frequencies of the molecular spectrum of nitric oxide: results and prospects of clinical use

Year: 2019, volume 15 Issue: №3 Pages: 800-806
Heading: Cardiology Article type: Original article
Authors: Parshina S.S., Afanasyeva T.N., Vodolagin A.V., Petrova V.D., Ushakov V.Yu., Kaplanova T.l., Potapova M.V., Ramazanova Z.G.
Organization: Saratov State Medical University, Clinical Hospital "RZD-Medicine", Saratov
Summary:

The purpose of the study is to summarize the results of clinical use of terahertz therapy at molecular spectrum of nitric oxide frequencies (150,176... 150,664 GHz) (THZ-therapy-NO) in cardiology, to identify general regularities and peculiarities of terahertz therapy influence. Material and Methods. We examined 312 patients with angina pectoris (150 patients with unstable angina pectoris, and 162 patients with stable angina of III-IV f. to.). Results. Antianginal effect of THZ-therapy-NO does not depend on the form of angina, sex, age, mode of exposure, hypocoagulation effect of smoking. We identified 2 types of effects of THZ-therapy-NO on hemostasis and blood rheology: active antithrombotic and protective (prevents the development of hypercoagulation shifts against the standard drug treatment). Procoagulant hemostasis is most sensitive to terahertz exposure. Reducing the duration of course exposure leads to expansion of antithrombotic effect by increasing the activity of natural anticoagulants (antithrombin III). Conclusion. Antianginal effect of THZ-therapy-NO does not depend on its hypocoagulation action. Irradiation mode "3/15" is optimal for patients with angina. Mode "2/5" does not have its own antithrombotic effect, therefore it is suitable for patients with angina with a tendency to hypocoagulation. Smoking does not affect the efficiency of the THZ-therapy-NO.

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Features of total peripheral resistance and regional vascular resistance in arterial hypertension

Year: 2019, volume 15 Issue: №3 Pages: 763-769
Heading: Cardiology Article type: Original article
Authors: Lukyanov V.F., Kaplanova T.l., Broyaka N.A., Gompassunon O.M. M., Varezhnikova O.V., Potapova M.V.
Organization: Saratov State Medical University
Summary:

The purpose of the study is to conduct comparative analysis of brachial artery's total peripheral resistance and vascular resistance in patients with arterial hypertension. Material and Methods. We applied standard measurement techniques for total peripheral resistance and blood flow parameters of the brachial artery in 128 patients suffering from the arterial hypertension. Results. The peripheral blood flow condition depends on the following indicators: kinetic energy of blood release (Wkin), brachial artery volumetric bloodstream (Vbr) and radius (Rbr), total peripheral resistance (TPR) and peripheral resistance (PRbr) of the brachial artery. Based on these indicators the patients were split into three groups according to pathogenetic variants of the hypertonic disease. Conclusion. The proposed criteria of the bloodstream status allows to verify arterial hypertension pathogenetic mechanisms. It implies personalized approaches to treatment of patients with arterial hypertension.

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