Saratov JOURNAL of Medical and Scientific Research

platelet-rich plasma

A standardized approach to the choice of basic surgical treatment for large macular holes

Year: 2020, volume 16 Issue: №2 Pages: 687-690
Heading: Ophtalmology Article type: Short message
Authors: Chuprov A.D., Kazennov A.N., Mambetova Е.М.
Organization: S. Fyodorov Eye Microsurgery Federal State Institution

The purpose of the study is to optimize the choice of tactics for surgical treatment of large macular holes. Material and Methods. Analysis of the surgical treatment of macular holes in 18 patients (18 eyes) was performed. Patients were divided into 3 groups. Group 1 (8 eyes) included patients with a hole diameter of up to 500±22 urn, group 2 (6 eyes) — with a diameter of up to 800±20 urn, and group 3 (4 eyes) — over 800 urn. In group 1 vitrectomy was performed with peeling of the inner border membrane (IBM), application of platelet rich plasma (PRP) mass and tamponade with air; in the group 2 vitrectomy was performed with IBM peeling, application of PRP mass or closed with a free inverted IBM flap and tamponade with SF6 gas; in group 3 vitrectomy was performed with IBM peeling and closing of the macular holes was performed using a free inverted IBM flap with silicone oil tamponade. Results. There was complete closure of the macular holes with the formation of a normal fovea profile and improvement of visual acuity in all cases of group 1. In group 2 (PRP application) in 2 cases of 6, a second intervention was required with the"plasty" of the macular hole using an inverted IBM flap. In group 3, in 1 case, the gap did not close and in 1 more case it closed with a defect at the level of the ellipsoid zone of the photoreceptors. Conclusion. The preliminary results' analysis showed the effectiveness of the developed algorithm for surgical treatment of macular holes, depending on their diameter, which is optimal and allows obtaining the required anatomical and functional result.

2020_02-1_687-690.pdf306.57 KB

Use of platelet rich plasma, including autologous conditioned plasma, in the surgery of perforating eye injuries

Year: 2020, volume 16 Issue: №1 Pages: 207-210
Heading: Ophtalmology Article type: Original article
Authors: Arsyutov D.G.
Organization: Republican Clinical Ophthalmologic Hospital, Сhuvashia

The purpose of the study is to evaluate the effectiveness of surgical treatment of double perforating eye injury of different localization and length with the damage to the retina, the vascular layer and the sclera of the posterior eye segment, using platelet rich plasma, including autologous conditioned plasma, without additional scleroplasty and endolaser photocoagulation. Material and Methods. The surgery technique involves carrying out 25+ gauge vitrec-tomy, removing the foreign body, posterior hyaloid membrane, in case of central and paracentral retinal detachment it involved removing the inner limiting membrane. Pneumoretinopexy was performed. After maximum removal of liquid between the air bubble and the tear we carried out instillation of platelet rich plasma or autologous conditioned plasma in 2-3 layers, involving retina around the tear, until full repair of the scleral-choroidal-retinal tear without laser coagulation, additional scleral suturing and external scleroplasty. The study involved nine patients with visual acuity from the incorrect visual projection to 0.02. Results. In the early postoperative period the retina was reattached in all the patients, the scleral-choroidal-retinal tear was blocked. In the long-term (1-12 months) period, no recurrent depressurization of the eyeball wall and retinal detachments were recorded. In two patients the healing was accompanied by the rough chorioretinal scar formation and retinal duplicate in the scarring area. The visual acuity of the operated patients was 0.03-0.4. Conclusion. Surgical treatment of the double perforating eye injury, accompanied by retinal detachment, with the use of platelet rich plasma and autologous conditioned plasma without laser coagulation of the retina, scleral suturing of the posterior eye segment and additional scleroplasty is a method that allows to achieve total scleral and chorioretinal repair and get a good anatomical and functional result.

2020_01-2_207-210.pdf299.08 KB

PRP-therapy efficiency analysis for various shoulder tendinopathies

Year: 2019, volume 15 Issue: №3 Pages: 648-653
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Norkin A.I., Malanin D.A., Tregubov A.S., Demeshchenko M.V., Cherezov L.L., Shormanov A.M., Emkuzhev O.L., Anisimova E.A.
Organization: Saratov State Medical University, Volgograd Medical Scientific Center, Volgograd State Medical University

Objective: to perform comparative analysis of PRP-therapy efficiency in patients with various shoulder tendinopathies. Material and Methods. 122 patients with rotator cuff tendinopathies (66%), subacromial impingements and rotator cuff tendinopathies (16%), CLB tendon tendinopathies (18%) participated in the research. The diagnostic scales for estimation of pain syndrome and shoulder joint function, as well as ultrasound and MRT examinations were employed to assess the outcomes in 1 and 6 months after PRP-therapy. Results. Patients of all groups had significant improvements by scales compared to their condition at the beginning of PRP-therapy. The positive response obtained in one month after the treatment still subsisted in 6 months. The most impressive responses to treatment were observed in patients with rotator cuff and CLB tendinopathies (strong middle effect 0.8-0.88). The patients of these groups self-estimated their outcomes relatively high. The scores defining outcomes were somewhat lower in the group of patients with both rotator cuff tendinopathies and subacromial impingements. Both MRT and ultrasound examinations revealed improvements in shoulder joint structures: edema reduction and dissipation, hypoechoic signal areas. Conclusion. PRP-therapy at shoulder tendinopathies may be referred to safe effective biological methods of treatment.

2019_03_648-653.pdf337.95 KB