Saratov JOURNAL of Medical and Scientific Research

Irkutsk State Medical Academy of Postgraduate Education

Clinical and immunological evaluation of pathological changes in the organ of vision in patients with open-angle glaucoma

Year: 2020, volume 16 Issue: №1 Pages: 237-241
Heading: Ophtalmology Article type: Original article
Authors: Malysheva Ju.V., Volkova N.V., Kursakova Ju.V.
Organization: Irkutsk State Medical Academy of Postgraduate Education, Irkutsk State Medical University, S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

The purpose is to perform clinical assessment of neurodegenerative and inflammatory changes in the visual organ in patients with advanced open-angle glaucoma and to identify the relationship between the degree of neurodegenerative and inflammatory changes. Material and Methods. Prospective examination of 26 patients with advanced open-angle glaucoma and 22 patients without changes in eye hydrodynamics with determination of TGF-p and MMR-9 concentrations in lacrimal and anterior chamber aqueous humor. Results. There was a statistically significant decrease in the concentration of MMR-9 in patients with glaucoma by 1.62 times in the lacrimal fluid (p<0.01) and by 2.17 times in the anterior chamber aqueous humor (p<0.05) in comparison with the control group. There was a statistically significant inverse relationship between MMP-9 in the lacrimal and the indicator characterizing a clinical picture of inflammatory reaction of the conjunctiva (p=0.02) and direct interdependence of the concentration of MMP-9 in the lacrimal and the thickness of the nerve fiber layer (p=0.02). Conclusion. The study revealed correlations between the degree of severity of the conjunctival inflammatory response, neurodegenerative changes, and the content of MMR-9 in the lacrimal and aqueous humor of the anterior chamber of patients with open-angle glaucoma.

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