Saratov JOURNAL of Medical and Scientific Research

Trunov A.N.

S. Fedorov Eye Microsurgery Federal State Institution, Novosibirsk Branch, Federal Research Center for Fundamental and Translational Medicine of the Siberian Branch of the Russian Academy of Sciences, Chief Researcher of the Laboratory of Immunology, Professor, DSc

The frst results of combined treatment of central serous chorioretinopathy using subthreshold micropulse laser exposure with 577 nm wavelength and injections of platelet autoplasma

Summary:

Aim: to compare the efects of a combination of subthreshold micropulse laser irradiation (SMPLI) with injections of autologous platelet plasma (PP) in the region of the pterygopal fossa on the afected side with the efect of SMPLI in central serous chorioretinopathy (CSСR). Material and Methods. This study was conducted on 60 patients (60 eyes) with CSCR. Patients were divided into 2 groups: in the comparison group patients received treatment only with SMPLI with a wavelength of 577 nm. In the experimental group patients received SMPLI with TP injections. TP was started after 72 hours, with 3 injections into the area of pterygopalatine fossa in the afected eye, with an interval between injections of 72 hours. Ophthalmologic examination, OCT and fuorescent angiography were carried out before treatment and 1, 3, 6 and 12 months after treatment, and ELISA assessment of IL-4, — 6 and -17A levels in lacrimal fuid was performed. Results. In the experimental group, where SMPLI+TP were performed, visual acuity has signifcantly improved, thickness of central section of macula was noted to have been decreased, and photosensitivity of central zone of retina signifcantly improved when compared to the SMPLI group. In the SMPLI+TP group the levels of IL-4, IL-6 and IL-17A in tear fuid increased. SMPLI was performed using Supra 577 nm laser device (Quantel Medical, France) over the entire area of macular edema. Conclusion. SMPLI+PRP treatment in patients with acute CSCR is efective for restoration of visual function.

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Efects of combined treatment for non-infectious uveitis with macular edema on cytokine composition of lacrimal fuid

Summary:

Purpose: to study the efects of combined treatment for non-infectious uveitis with macular edema using platelet autoplasmin to estimate the cytokine content in lacrimal fuid. Material and Methods. 120 people aged 18 to 50 years with non-infectious uveitis and macular edema were examined: 46 men, 74 women. The patients were divided into 2 groups: main group (anti-infammatory treatment and the administration of platelet autoplasma); comparison group (anti-infammatory treatment). Patients underwent standard ophthalmological examination. To assess the activity of local infammatory process a study of cytokine content in the lacrimal fuid before and after treatment was conducted. Results. In patients with non- infectious uveitis the use of platelet autoplasma in the treatment of patients assigned to the main group lead to a statistically signifcant increase in the concentrations of IL-4, IL-6, IL-8, IL-17A in the lacrimal fuid. A statistically signifcant decrease in the concentrations of proinfammatory cytokines was observed when auto-plasma was used. Conclusion. The use of platelet autoplasma in the treatment of patients with non-infectious uveitis with macular edema is pathogenetically justifed, as it is associated with a pronounced decrease in the activity of the immuno-infammatory process, which is confrmed by the

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