Saratov JOURNAL of Medical and Scientific Research

Safonenko A.Yu.

A. I. Yevdokimov Moscow State University of Medicine and Dentistry, Ophthalmologist, Post-graduate student of Eye Diseases Department

Optical coherent tomography — angiography at atrophy of the visual nerve with multiple sclerosis

Year: 2020, volume 16 Issue: №2 Pages: 559-563
Heading: Ophtalmology Article type: Original article
Authors: Andrusyakova Е.Р., loyleva Е.Е., Kalinchenko S.Yu., Safonenko A.Yu., Krivosheyeva M.S.
Organization: State Budgetary Healthcare Institution of the Moscow Region «Sergiev Posad District Hospital», S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

The purpose of the study is to assess the state of microcirculation of the optic nerve disk of the peripapillary retina in patients with optic atrophy (OA) with multiple sclerosis without a history of optical neuritis (MS-ON). Material and Methods. We examined 34 eyes of patients with OA with MS-ON and 39 eyes of healthy volunteers comparable in gender and age. In addition to standard ophthalmological examination, all patients underwent optical coherence tomography with the function of angiography (OCT-A) of the optic nerve head (ONH) with the measurement of thickness of the peripapillary retina and the relative density of capillaries, as well as the measurement of thickness of the complex of retinal ganglion cells (GCC). To assess the diagnostic value of OKT-A, a ROC-analysis was performed using the most informative predictors. Results. According to the results of OCT-A in patients with MS-ON, the most pronounced differences in the indicators were revealed for all indicators of the thickness of the peripapillary layer of the retinal nerve fibers (RNFL) and the relative density of the retinal peripapillary capillaries (RPC) in all sectors compared with the control group, as well as a decrease in the average indicators in the complex of retinal ganglion cells (GCC). A moderate direct correlation was found between the thicknesses of the peripapillary RNFL and the density of the RPC (r = 0.50; p <0.05), as well as with the average GCC values (r=0.69; p<0.05). Conclusion. In patients with optic atrophy against the background of multiple sclerosis without optical neuritis in the anamnesis with the help of OCT-A, we detected a significant decrease in the RNFL thickness and RPC density, compared to the norm, which indicates a deterioration in the microcirculation of the peripapillary retina associated with the process of neurodegeneration.

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SD-OCTA parameters of the optic disk and peri papillary retina in older age group

Year: 2020, volume 16 Issue: №1 Pages: 265-268
Heading: Ophtalmology Article type: Original article
Authors: Safonenko A.Yu., loyleva Е.Е., Gavrilova N.A.
Organization: S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

The purpose of the study is to investigate the optic disk and peripapillary retina parameters using SD-OCTA in people of an older age group. Material and Methods. 31 patients (62 eyes), 12 males and 19 females, mean age 57.1 ±9.6 were examined. All patients underwent SD-OCT and SD-OCTA examination (RTVue XR, Optovue), by using protocol HD Angio Disk 4.5*4.5 mm. SD-OCT and SD-OCTA were used to measure the radial peripapillary capillaries (RPC, %) and retinal nerve fiber layer thickness (RNFL, urn), rim area, disc area, cup volume. Results. Mean value of the RNFL thickness was 109.7±11.1 urn. The lower value of the RNFL thickness was observed in "Tempo Inferior" and "Tempo Superior" segments. Rim area was 1.66±0.33 mm2, disc area 1.87±0.28 mm2. The mean value of RPC density in peripapillary retina was 52.2±2.3%. The lower value of the RPC density was in "Nasal Inferior" and "Superior Nasal" segments, 48.9±3.2 and 49.9±3.1 %, respectively. Conclusion. The reference values of the optic disk and peripapillary retina parameters for senior Russian citizens, which were developed with RTVue XR Avanti (Optovue Inc., USA) device, can be used as diagnostic criteria for neuroophthalmological pathology.

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Results of a seven-year follow-up of an atypical form of multiple sclerosis, Marburg variant

Year: 2019, volume 15 Issue: №2 Pages: 414-418
Heading: Ophtalmology Article type: Case report
Authors: Andrusyakova Ye.P., Ioyleva Ye.E., Safonenko A.Yu., Krivosheeva M.S., Pis'menskaya V.A.
Organization: "Eye Microsurgery" n.a. academician S. N. Fedorov, Volgograd branch, Moscow State Medical Stomatological University n.a. A. I. Evdokimov
Summary:

Marburg disease afects young people and is characterized by an acute onset with a fulminant course. The disease leads to death within 1 year from the onset of symptoms. In Academician S. N. Fedorov «Eye Microsurgery» Center (Moscow) a patient with Marburg multiple sclerosis was followed up for seven years. Standard treatment in combination with physiotherapy treatment slowed the development of an irreversible decrease in visual function due to atrophy of the optic nerves.

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