Saratov JOURNAL of Medical and Scientific Research

Ioyleva Ye.E.

S. Fedorov Eye Microsurgery Federal State Institution, Academic Secretary; A. I. Yevdokimov Moscow State University of Medicine and Dentistry, Professor of Department of Eye Diseases, Professor, DSc

SD-OCTA parameters of the optic disk and peri papillary retina in older age group

Year: 2020, volume 16 Issue: №1 Pages: 265-268
Heading: Ophtalmology Article type: Original article
Authors: Safonenko A.Yu., loyleva Е.Е., Gavrilova N.A.
Organization: S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

The purpose of the study is to investigate the optic disk and peripapillary retina parameters using SD-OCTA in people of an older age group. Material and Methods. 31 patients (62 eyes), 12 males and 19 females, mean age 57.1 ±9.6 were examined. All patients underwent SD-OCT and SD-OCTA examination (RTVue XR, Optovue), by using protocol HD Angio Disk 4.5*4.5 mm. SD-OCT and SD-OCTA were used to measure the radial peripapillary capillaries (RPC, %) and retinal nerve fiber layer thickness (RNFL, urn), rim area, disc area, cup volume. Results. Mean value of the RNFL thickness was 109.7±11.1 urn. The lower value of the RNFL thickness was observed in "Tempo Inferior" and "Tempo Superior" segments. Rim area was 1.66±0.33 mm2, disc area 1.87±0.28 mm2. The mean value of RPC density in peripapillary retina was 52.2±2.3%. The lower value of the RPC density was in "Nasal Inferior" and "Superior Nasal" segments, 48.9±3.2 and 49.9±3.1 %, respectively. Conclusion. The reference values of the optic disk and peripapillary retina parameters for senior Russian citizens, which were developed with RTVue XR Avanti (Optovue Inc., USA) device, can be used as diagnostic criteria for neuroophthalmological pathology.

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Evaluation of retinal neuroarchitectonics in presence of optic nerve head drusen

Year: 2019, volume 15 Issue: №2 Pages: 490-494
Heading: Ophtalmology Article type: Review
Authors: Kabanova EA, Ioyleva EE, Zinovyeva AV.
Organization: Moscow State Medical Stomatological University n.a. A. I. Evdokimov, The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose: assessment of retinal neuroarchitectonics in presence of optic nerve head (ONH) drusen. Materials and Methods. 108 patients (216 eyes) with bilateral drusen of the optic disc aged 18–60 years were examined, and the control group consisted of 28 healthy subjects. All patients underwent optical coherence tomography (OCT) using Cirrus HD-OCT 5000–7544 device (Carl Zeiss Meditec Inc.). Results. Three types of ONH drusen localization relative to the Bruch membrane were identifed: superfcial, deep and difuse. Difuse localization of the drusen was determined in 48.6 % of cases, deep — in 40.3 %, superfcial — in 11.1 %. Deep optic disc drusen were more common in a young age (35.5±13.1 years), difuse — in medium age (42.0±13.2 years), superfcial — at an older age (51.7±12.8 years). With superfcial and difuse drusen of the optic disc, a signifcant (p<0.05) decrease in the thickness of the ganglion cell (GC) layer in all studied sectors, a decrease in the minimum and average GC thickness was found, as well as a signifcant (p<0.05) decrease in the average thickness and cubic volume of the neuroepithelium. With deep drusen opacities, the changes in GC were less pronounced and statistically insignifcant. Conclusion. analysis of the obtained data showed that deep drusen of the optic disc are the initial stage of congenital pathology, difuse drusen are a developed stage, and superfcial drusen of the optic disc characterize the development of fnal stage.

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Diagnostic criteria for optic nerve atrophy in patients with multiple sclerosis determined by next generation spectral optical coherence tomography

Summary:

Purpose: identifcation of diagnostic criteria for optic nerve atrophy by spectral optical coherent tomography in patients with multiple sclerosis (MS). Material and Methods. 81 patients with optic nerve atrophy due to MS (37 men, 44 women, mean age 35.6±3.7 years) were examined using spectral optical coherent tomography (S-OCT). Results. We obtained reliable data suggesting on the asymmetry of S-OCT parameters in patients with multiple sclerosis and optic nerve atrophy. In the process of a detailed assessment of the thickness of the GCS+IPL complex, signifcant difer-ences in the worst and paired eyes were obtained. In addition, when the total aggregating all of the results obtained by the method of binary logical regression determined the threshold for partial atrophy of the optic nerve due to MS. The average thickness of GCS+IPL complex, as determined by S-OCT, is a reliable marker of neuroaxonal degeneration in patients with optic nerve atrophy due to MS. Conclusion. S-OCT criteria for optic nerve atrophy in multiple sclerosis are a decrease in the average thickness of the retinal nerve fber layer of less than 62 microns, combined with a decrease in the average thickness of retinal ganglion cell complex and the inner plexiform layer less than 52 microns, thickness of upper segment of GCS+IPL less than 51 μm, and the lower segment of GCS+IPL less than 50 microns.

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Mechanisms of optic nerve damage in patients with hemoblastosis

Year: 2019, volume 15 Issue: №2 Pages: 482-485
Heading: Ophtalmology Article type: Case report
Authors: Ioyleva E.E., Gadzhieva N.S., Zinovyeva A.V.
Organization: "Eye Microsurgery" n.a. academician S. N. Fedorov, Volgograd branch, Moscow State Medical Stomatological University n.a. A. I. Evdokimov
Summary:

The development of optic neuropathy in leukemia and lymphomas has a wide range of etiological factors, being a result of neoplastic, infectious, compression, ischemic and toxic damage. Patients in the older age group may have cardiovascular risk factors that increase the risk of developing lesions of the optic nerve. Timely diagnosis of optic neuropathy in hemoblastosis and the choice of the optimal treatment method allow to maintain high visual function and improve patients» quality of life. The paper presents a clinical case of unilateral ischemic neuropathy in patients with clinical and hematological remission of acute myeloblastic leukemia and the presence of cardiovascular risk factors, as well as heart failure.

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Results of a seven-year follow-up of an atypical form of multiple sclerosis, Marburg variant

Year: 2019, volume 15 Issue: №2 Pages: 414-418
Heading: Ophtalmology Article type: Case report
Authors: Andrusyakova Ye.P., Ioyleva Ye.E., Safonenko A.Yu., Krivosheeva M.S., Pis'menskaya V.A.
Organization: "Eye Microsurgery" n.a. academician S. N. Fedorov, Volgograd branch, Moscow State Medical Stomatological University n.a. A. I. Evdokimov
Summary:

Marburg disease afects young people and is characterized by an acute onset with a fulminant course. The disease leads to death within 1 year from the onset of symptoms. In Academician S. N. Fedorov «Eye Microsurgery» Center (Moscow) a patient with Marburg multiple sclerosis was followed up for seven years. Standard treatment in combination with physiotherapy treatment slowed the development of an irreversible decrease in visual function due to atrophy of the optic nerves.

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