Saratov JOURNAL of Medical and Scientific Research

Kiriyazi T.S.

Saratov Medical University "Reaviz", Associate Professor of Department of Biomedical Sciences, PhD

The role of histaminergic system in the effects of skin flap autotransplantation on microcirculation at absolute insulin deficiency

Year: 2020, volume 16 Issue: №2 Pages: 521-525
Heading: Рathophysiology Article type: Original article
Authors: Antipova O.N., Lagutina D.D., Stepanova T.V., Savkina A.A., Kuznetsova N.A., Andronova Т.А., Kiriyazi T.S, Ivanov A.N.
Organization: Saratov Medical University "Reaviz", Saratov State Medical University

The objective of the article is to estimate the impact of the histaminergic system in the effects of skin flap autotrans-plantation (SFA) on microcirculation in white rats with alloxan insulin deficiency. Material and Methods: The studies were carried out in 60 white rats, divided into 3 groups: 20 control intact animals, 20 animals with alloxan diabetes — the comparison group, 20 animals with alloxan diabetes and SFA— the experimental group. The mechanisms of blood circulation modulation and perfusion of posterior paw dorsal skin, the concentration of histamine in the blood serum, and morphological changes in the SFAarea were evaluated. Results: The significant increase of skin perfusion on 43%, redistribution of microcirculation modulation active mechanisms and the increase in histamine serum concentration in 2,5 times underthe influence of SFA were observed in rats of the experimental group. Conclusion: The distant stimulating effect of SFA on microcirculation in conditions of absolute insulin deficiency is realized with increasing histamine serum concentration. Moreover, the stimulation of the blood flow regulation active mechanisms by increasing the histamine concentration is not equivalent — the effects on endothelium-dependent and neurogenic regulation mechanisms prevail, and the activation of histamine smooth muscle cell receptors is much less pronounced.

2020_02_521-525.pdf854.23 KB

Features of angiogenesis in skin tissue regeneration

Year: 2019, volume 15 Issue: №1 Pages: 104-107
Heading: Physiology and Pathophysiology Article type: Review
Authors: Pronina Е.А., Stepanova T.V., Kiriyazi T.S., Maslyakov V.V., Ivanov A.N.
Organization: Saratov Medical University "Reaviz", Saratov State Medical University, Saratov State Technical University n.a. Yu.A. Gagarin

Restoration and regeneration of tissues are complex processes involving a large number of signaling mechanisms. In this study possible mechanisms of angiogenesis during tissue regeneration are presented. One of these mechanisms is the creation of a new capillary layer by angiogenesis. Previously it was believed that high and rapid levels of capillary growth are necessary for optimal healing of tissues. But several studies have demonstrated that a period of vascular regression occurs after the growth of blood vessels in a wound, and the number of the newly formed vessels decreases until the number of the blood vessels is equal to the density of the vascular network in the intact tissue. Reduced inflammation and angiogenesis are features of optimal healing.

2019_1_104-107.pdf240.32 KB