Saratov JOURNAL of Medical and Scientific Research

intraocular infection

Ophthalmic medicinal films in the prevention of infectious and inflammatory complications

Year: 2018, volume 14 Issue: №4 Pages: 933-938
Heading: Ophtalmology Article type: Review
Authors: Aznabaev М.Т., Azamatova G.A., Gaysina G.Ya.
Organization: Bashkir State Medical University of the Russian Health Care

This review focuses on prolonged dosage form — ophthalmic medicinal films. The composition, method of manufacturing the main eye films used in ophthalmology, the mechanism of prolongation of the immobilized drug substance are considered. The evacuation of the antibiotic from the polymer matrix, the pharmacokinetics of the drug, the therapeutic effect of the use of films was studied. When using eye films with an antibiotic in the chamber moisture of the eye, a therapeutically effective concentration of the drug substance is created and maintained for a long time. Ophthalmic medicinal films have significant advantages over the widely used methods of preoperative prevention of infection complications. Of great interest are eye films with fluoroquinolones based on a polysaccharide-modified matrix. Developed ophthalmic medicinal films have, in addition to the specific biological effects of an effective antibiotic, additional desired properties. The most promising forms of eye films for the prevention and treatment of intraocular infection are highlighted.

2018_4-2_933-938.pdf383.65 KB