Saratov JOURNAL of Medical and Scientific Research

Chochaeva A.M.

S. Fyodorov Eye Microsurgery Federal State Institution, fellow of Department of Ocular Oncology and Radiology

Comparison of uveal melanoma molecular classification systems

Year: 2018, volume 14 Issue: №4 Pages: 898-890
Heading: Ophtalmology Article type: Original article
Authors: Yarovoy А.А., Yarovaya V.A., Chudakova L.V., Chochaeva A.M., Loginov R.A., Kleyankina S.S., Zaretsky A.R.
Organization: Evrogen Laboratory LLC, The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose: to compare cytogenetic and mutational classifications of uveal melanoma (UM) in comprehensive analysis. Material and Methods. UM tissue from 154 eyes treated by enucleation or eye-sparing treatment was analyzed. Analysis included FISH for monosomy 3 and 8q gain, PCR for GNAQ, GNA11, EIF1AX and SF3B1 mutations and immunohistochemistry for BAP1. The group of 66 patients was used to compare cytogenetic and mutational classifications of uveal melanoma. Results. Discrepancy between cytogenetic and mutational classifications was revealed in 79% of cases. Unusual combination of EIF1 AX mutation with monosomy 3 or BAP1 inactivation was seen. Conclusion. Prognostic significance of the discrepancy between the two UM classifications is currently unknown. Further research is needed.

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Results of combined treatment of iris cysts

Year: 2018, volume 14 Issue: №4 Pages: 891-894
Heading: Ophtalmology Article type: Original article
Authors: Yarovoy А.А., Bulgakova E.S., Yarovaya V.A., Chochaeva A.M., Korobov E.N.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose. To present the own experience in iris cyst treatment. Materials and Methods. In this retrospective study 20 eyes with iris cysts were included. Lesions were managed with intracystic ethanol irrigation with and without subsequent surgical resection of the walls. Results. Complete iris cyst destruction was achieved in 16 cases. In 4 eyes cyst recurrence after ethanol irrigation was revealed and successfully treated by ethanol irrigation without subsequent surgical resection of the walls. No complications were seen within mean follow-up of 26 months. Conclusion. Intracystic ethanol irrigation is an effective treatment modality. Additional surgical resection of the cyst walls helps to improve treatment results with no signs of recurrences and complications.