Saratov JOURNAL of Medical and Scientific Research

Kolesnikov A.V.

Ryazan State Medical University n.a. academician I. P. Pavlov, Head of Department of Ophtalmology and ENT Diseases, Associate Professor, PhD

Oxidative stress and methods of its correction in corneal burns (review)

Year: 2020, volume 16 Issue: №2 Pages: 459-463
Heading: Ophtalmology Article type: Review
Authors: Kolesnikov A.V., Kirsanova I.V., Sokolova A.I., Ban E.M.
Organization: Ryazan State Medical University n.a. I.L.Pavlov
Summary:

The article presents actual ideas about the role of oxidative stress in the pathogenesis of corneal burns and methods of its correction. Corneal burns are rather common ophthalmic pathology. Corneal burns are difficult to treat, so they often lead to a decrease in visual acuity and, as a result, disability of young people. Despite the high antioxidant protection of the eye structures, under the influence of damaging environmental factors on the cornea (ultraviolet, chemicals, high temperatures, etc.), there is an increase in the concentration of free radicals with a decrease in the level of antioxidants — oxidative stress develops, aggravating damage to the cornea. Medicaments with antioxidant properties have shown their efficacy in the treatment of corneal burns.

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Effect of cataract phacoemulsification on the dynamics of intraocular pressure in patients with primary open-angle glaucoma

Year: 2018, volume 14 Issue: №4 Pages: 837-841
Heading: Ophtalmology Article type: Original article
Authors: Kolesnikov A.V., Kolesnikova M.A., Mironenko L.V., Baranova O.V., Tarasova N.S.
Organization: Ryazan State Medical University n.a. I.L.Pavlov, Regional Clinical Hospital n.a. N.A. Semashko
Summary:

Purpose: to assess the dynamics of intraocular pressure (IOP) after cataract phacoemulsification (CFE) with intraocular lens (IOL) implantation in patients with cataract in combination with primary open-angle glaucoma (POAG). Material and Methods. The subject of this study was the analysis of IOP after CFE in 65 patients (89 eyes) with cataract in combination with POAG. Among the examined patients, the initial stage of glaucoma was noted in 14.6% cases; developed stage in 55.1 % cases, far-reaching stage in 30.3% cases. IOP was compensated in 84.5% cases, and sub-compensated in hypotensive mode in 15.5% cases. The observation period was from 1 month up to 2 years. Results. In dependence of IOP after surgery, patients were divided into three groups: IOP exactly like in preoperative level, below and above the initial IOP In most cases, at all times IOP corresponded to the preoperative level and after 2 years it was noted in 77.4%. The number of patients with ophthalmotonus below the baseline (1-8 mm) decreased from 63.2% in 1-3 months after surgery to 16.1 % in two years. An increase in ophthalmotonus (by 3-4 mm) was noted in 27% of cases, however, a persistent increase in IOP, which required correction, was 7.9% at stage III of glaucoma, and in the rest of the eyes IOP normalized by itself. Conclusion. According to the results of the study, it can be concluded that there is an ambiguous effect of CFE with IOL implantation on IOP in patients with cataract in combination with POAG, which necessitates further study.

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