Saratov JOURNAL of Medical and Scientific Research

Mikhaylova E.V.

Saratov State Medical University, Head of Department of Children Infectious Diseases, Professor, Doctor of Medical Science

То the anniversary of Irina Alexandrovna Zaitseva

Year: 2017, volume 13 Issue: №1 Pages: 99-100
Heading: anniversary Article type: Short message
Authors: Mikhailova Е.М., Malyugina T.N., Ruskina Е.Е.
Organization: Saratov State Medical University
Summary:

The article is devoted to the 80th anniversary of professor Irina Alexandrovna Zaitseva — the honored worker of science, honored doctor of the Russian Federation

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Infectious mononucleosis in children: clinical and laboratory rationale and economic efficiency of application of immunocorrectors

Year: 2013, volume 9 Issue: №3 Pages: 512-517
Heading: Stomatology Article type:
Authors: Shvedova N.M., Mikhailova E.V., Tseka Y.S., Chudakova Т.К.
Organization: Saratov State Medical University
Summary:

Objective: to select the optimal, clinically and economacally effective immunocorrector for the treatment of immune-EBV — mononucleosis in children. Materials: 400 patients with primary Epstein — Barr virus infection aged 1 to 14 years. Results. The therapy by cycloferon of primary Epstein — Barr virus infection observed a statistically significant reduction in the length of stay of patients in hospital, on average, 3 bed-days. Inclusion of cycloferon, viferon in the treatment of infectious mononucleosis, reduces the severity and duration of symptoms of intoxication, the temperature reaction, hepatotoxicity, splenomegaly, lymphoproliferative syndrome. Against the background of cycloferon lower incidence of post-infection anemia was observed. Conclusion. The inclusion of immunocorrectors into therapeutic interventions in primary Epstein — Barr virus infection has been clinically and economically proved.

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Rotavirus infection in children: clinical and laboratory features and catamnesis

Year: 2013, volume 9 Issue: №3 Pages: 504-508
Heading: Infectious Diseases Article type: Original article
Authors: Mikhailova E.V., Levin D.U., Danilov A.N., Koshkin A.P., Lavrentiev G.P.
Organization: Saratov State Medical University
Summary:

Purpose is to study the clinical, laboratory and instrumental characteristics of the course of rotavirus infection in children up to 3 years in the acute phase and during the convalescence period. Material and methods. A clinical, laboratory and instrumental examination of 320 children up to 3 years with moderate to severe rotavirus infection. Results. The presence of long-term persistence of rotavirus recovering from rotavirus infection. Identified functional disorders of the digestive system in the acute period and the period of convalescence in children up to 3 years with rotavirus infection. Conclusion. For a long period (up to 3 months), almost half of patients may experience intestinal dysfunction, possibly related to the long-term persistence of rotavirus.

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National calendar of preventive vaccination: problems, solutions and results in Saratov region

Year: 2013, volume 9 Issue: №2 Pages: 192-196
Heading: Infectious Diseases Article type: Review
Authors: Uchaikin V.F., Shamsheva O.V., Mikhailova ЕМ., Shvedova N.M
Organization: Saratov State Medical University, Russian State Medical University
Summary:

National immunization calendar of Russia includes 11 entities that are carried out against the mass vaccination of children. And at the present time there is a high incidence of tuberculosis, whooping cough, measles incidence is increasing. In the article the causes have been analyzed, some possible solutions have been drawn.

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Клинико-эпидемиологическая характеристика гриппа в постпандемический период

Year: 2013, volume 9 Issue: №2 Pages: 186-192
Heading: Infectious Diseases Article type: Original article
Authors: Maleev V.V., Mikhailova E.V., Chudakova Т.К., Romanovskaya A.M., Danilov A.N., Khripunova G.I., Dubovitskaya N.A.
Organization: Central Scientific Research Institute of Epidemiology, Saratov State Medical University
Summary:

Objective: To analyze the clinical and epidemiological characteristics in the post-pandemic influenza seasons in 2010/11/12/13 years. Material and methods: The analysis of the incidence of acute respiratory viral infections and flu in the Saratov region from 2009 to 2013. A clinical and laboratory examination of 252 patients with a diagnosis of «flu»: 152 pregnant women at different stages of pregnancy at the age of 18 years to 41 years and 100 children aged from 5 months to 14 years. The work was carried out to assess the epidemiological pattern and clinical course of influenza, and the effective operation of antiviral therapy. Results: In the post-pandemic period 2010-2013 simultaneously circulating influenza A viruses (N1N1/09) pd, influenza A (H3N2) and influenza B. In most cases, influenza in adults and children is of moderate form. All serious forms of influenza have been caused by influenza A with the development of viral-bacterial pneumonia, respiratory failure and neurotoxic syndrome. Late hospitalization and absence of antiviral therapy in the prehospital are at risk of severe and complicated forms. Conclusion: Early initiation of antiviral therapy is one of the main factors for the effectiveness of treatment and reduce the risk of influenza complications.

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Professor N.R. Ivanov and his contribution to the development of infectious service

Year: 2013, volume 9 Issue: №2 Pages: 163-165
Heading: Infectious Diseases Article type: Short message
Authors: Popkov V.M., Mikhailova Е.V., Zaitseva I.A.
Organization: Saratov State Medical University
Summary:

The article presents biographic data of professor N. R. Ivanov and reflectshis contribution to the development of the national department of infectious service and the department of children infectious diseases at Saratov Medical University.

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Issue of acute respiratory viral infection and influenza A (H^swin) in modern obstetrics

Year: 2012, volume 8 Issue: №2 Pages: 218-223
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Salov I.A., Romanovskaya А.V., Mikhailova E.V.
Organization: Saratov State Medical University
Summary:

Objective: To study the clinical features of the course and outcome of pregnancy accompanied by acute respiratory viral infections and influenza A (HN^win). Methods and materials. 152 pregnant women who suffered from influenza A (H l^swin), acute respiratory viral infections in different duration of gestation. Results. Similar clinical symptomatology of both influenza A (H1N1 swin) and acute respiratory viral infections during the period of epidemic raise of influenza allow to suggest present nosology including pregnant patients with acute respiratory viral infections. Conclusion. In 4 cases the fatal outcome from influenza related to presence of associated pathology and development of the severe form of influenza complicated by acute respiratory and cardiovascular insufficiency, pulmonary edema, and cerebral edema were registered

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Liver Functional State Changes At Epstein-Barr Virus Mononucleou-sis In Children

Year: 2009, volume 5 Issue: №4 Pages: 572-577
Heading: Infectious Diseases Article type: Original article
Authors: S.A. Khmilevskaya, LA. Zaytseva, E. V. Mikhailova
Organization: Saratov State Medical University
Summary:

The research presents the results of medical observation of 439 patients aged 1-18 with mononucleosis of Epstein-Barr Virus etiology. By means of instrumental and clinical laboratory methods of investigation the peculiarities of liver condition have been revealed in children of different age. The intensity of autosensibilization processes to the tissues of the organ has also been estimated. The results obtained demonstrate the interrelation of clinical, biochemical and instrumental signs of liver damage, as well as contribution of autoimmune processes to the development of organopa-thology at Epstein-Barr Virus infection

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Epstein-Barr Viral Infection in Children: Cytokine Response Peculiarities and Immunopathological Reactions

Year: 2009, volume 5 Issue: №2 Pages: 222-226
Heading: Infectious Diseases Article type: Original article
Authors: S.A. Khmilevskaya, I.A. Zaytseva, E.V. Mikhaylova
Organization: Saratov State Medical University
Summary:

The research results are presented in the work. 100 patients aged 1–18 with different Epstein-Barr viral infection course variations have been observed. Clinical features of infectious mononucleosis in case of primary infection and its revivification have been revealed. The evaluation of intensity of autosensibilization processes has been performed. The interrelation of autoimmune and cytokine reactions and their participation in formation of organopathology in case of Epstein-Barr viral infection are demonstrated.

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