Nikitina N.M.

The article presents a clinical case of systemic lupus erythematosus with severe thrombocytopenia in a 55 year old patient. The standard therapy of usage of high doses of glucocorticoids, cyclophosphamide and intravenous im-munoglobulin was not effective. Application of Rituximab improved the course of disease, decreased the severity of thrombocytopenia, led to disappearance of leucopenia and anemia.

The aim of the article is to present a clinical case of rapid generalization of eosinophilic granulomatosis with polyangiitis. The course of disease with multiple organ lesions and the heart being affected the most is described. Remission is achieved by combined therapy with corticosteroids and cyclophosphamide.

The article presents clinical case of unfavorable outcome of amyloidosis of kidneys in a patient with rheumatoid arthritis. The absence of basic treatment and persistent activity of disease leads to fast progression of nephrotic stage of secondary amyloidosis in a young woman.