Saratov JOURNAL of Medical and Scientific Research

Kozlova I.V.

Saratov State Medical University n.a. V.I. Razumovsky, Head of Department of Therapy, Gastroenterology and Pulmonology, Professor, DSc

Comorbidity in the practice of a pulmonolo-gist: gastroesophageal reflux disease, Zenker's diverticulum and bronchopulmonary pathology (a clinical case)

Year: 2020, volume 16 Issue: №2 Pages: 438-442
Heading: Internal Diseases Article type: Case report
Authors: Kozlova I.V., Shashina M.M., Shapovalova T.G., Ryabova A.Yu., Belonozhko A.N.
Organization: Saratov State Medical University
Summary:

A clinical observation of a comorbid state in a 72-year-old patient with chronic bronchopulmonary pathology is presented in the work. Gastroesophageal reflux disease and large Zenker's diverticulum have been revealed. Diseases manifested simultaneously, progressed in parallel, but were not regarded as comorbid, which did not allow optimizing their therapy and prognosis.

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Gender peculiarities of cardiovascular pathology in patients with chronic obstructive pulmonary disease

Year: 2019, volume 15 Issue: №1 Pages: 28-33
Heading: Internal Diseases Article type: Original article
Authors: Ryabova A.Yu., Kozlova I.V., Shapovalova T.G., Shashina M.M., Veselov V.V., Zemlyanskaya O.V.
Organization: Saratov State Medical University
Summary:

Purpuse: to research the gender-specific features of cardiovascular disease in the group of patients with chronic obstructive pulmonary disease (COPD). Material and Methods. We conducted a cross-sectional retrospective research of 419 patients hospitalized with exacerbation of COPD to the Pulmonology Department of Saratov Clinical Hospital №8 from 2015 to 2017 By the method of independent target sample, taking into account gender and multimorbidity 169 patients with COPD and cardiovascular disease were included into the research. Results. Relation between the nosological forms and the frequency of occurrence of cardiovascular pathology in the group of patients with COPD is gender- dependent. Gender features of heart remodeling in the group of patients with COPD and cardiovascular pathology are revealed. Women have more therapy adherence. Conclusion. The data that we obtained indicate the characteristics of the formation and course of the cardiovascular pathology in patients with COPD gender-dependent. Research of the features determines the optimal tactics of treatment, improves the prognosis and quality of life of co-morbid patients.

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The problem of management of pregnant women with ulcer colitis

Year: 2018, volume 14 Issue: №4 Pages: 629-632
Heading: Internal Diseases Article type: Author's opinion
Authors: Kudishina M.M., Kozlova I.V.
Organization: Saratov State Medical University
Summary:

The relevance of the study of inflammatory bowel diseases in pregnant women is due to the rise of the disease at a young age (20-30 years), which accounts for the period of active childbirth. Treatment of pregnant women with ulcer-ative colitis and Crohn's disease remains a difficult problem for both doctors and patients. This work aims to analyze the features of the course and treatment of ulcerative colitis in pregnant women, to identify problems in the tactics of management on a real clinical example.

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Irritable bowel syndrome: epidemiological and pathogenetic aspects

Year: 2018, volume 14 Issue: №1 Pages: 53-60
Heading: Internal Diseases Article type: Review
Authors: Tikhonova Т.А., Kozlova I.V.
Organization: Saratov State Medical University
Summary:

The literature review focuses on some epidemiological aspects, molecular-genetic predictors of irritable bowel syndrome formation, the role of psychosocial and infectious factors, low-grade inflammation, imbalance between neu-rotransmitters and cytokines, as well as changes in the intestinal microbiome in the development of irritable bowel syndrome.

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Molecular and genetic predisposing factors of comorbidity of fatty liver disease and diseases of the colon

Year: 2017, volume 13 Issue: №1 Pages: 029-034
Heading: Internal Diseases Article type: Review
Authors: Lapteva Е.А., Kozlova I.V.
Organization: Saratov State Medical University
Summary:

The literature review is devoted to the universal molecular markers and predictors of forming non-alcoholic fatty liver disease and pathology of the colon, the role of insulin resistance as one of the factors of the pathogenesis of non-alcoholic fatty liver disease in the development of colorectal cancer. The mechanisms of diseases of the colon (colorectal cancer) are found out to be due to non-alcoholic fatty liver disease.

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Psychological characteristics of patients with functional and inflammatory bowel disorders

Year: 2014, volume 10 Issue: №1 Pages: 80-85
Heading: Internal Diseases Article type: Original article
Authors: Kozlova I.V., Myalina Yu.N., Lekareva L.I., Badieva O.E., Tikhonova Т.А.
Organization: Saratov State Medical University
Summary:

Objective: to study the psychological characteristics of patients with irritable bowel syndrome (IBS), ulcerative colitis (UC), Crohn's disease (CD). Material and methods. The study group included 98 patients with IBD (inflammatory bowel disease) and IBS, the control group included 30 healthy individuals. Set of psychological tests included questionnaire (multifactorial systemic examination of the person), the Luscher color test, Beck Depression Inventory, a test on health, activity, mood. Results. Premorbid personality traits, communication disorders with stress have been revieled. According to the nosology different types of emotional response to the disease, changes in health and activity have been marked. There is a high level of frustration needs, increased frequency of anxiety and depression in all patients. Conclusion. Psychological mechanisms of pathology are similar in functional and organic bowel diseases with the greatest influence on the course of functional disorders.

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Colon polyps: epidemiology, risk factors, diagnostic criteria and courses of treatment

Year: 2013, volume 9 Issue: №2 Pages: 252-259
Heading: Internal Diseases Article type: Review
Authors: Lapteva Е.А., Kozlova I.V., Myalina J.N., Pakhomova A.N.
Organization: Saratov State Medical University
Summary:

Article focuses on the intestinal polyps. Intestinal polyps are considered to be obligatory precancerous diseases of the colon. Risk factors, epidemiology, clinical manifestations and diagnostic methods of polyps have been analyzed. The courses of treatment of colon polyps have been revealed.

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Material selection for prosthetics of defects of dentitions at patients with functional and inflammatory bowel diseases

Year: 2012, volume 8 Issue: №2 Pages: 293-297
Heading: Stomatology Article type: Original article
Authors: Eremin O.V., Lepilin A.V., Kozlova I.V., Myalina Yu.N.
Organization: Saratov State Medical University
Summary:

Objective: To study clinical-morphological characteristics of parodontal diseases, markers of density of bone tissue and to define rational approaches to prosthetics of defects of dentitions in patients with colon diseases. Materials and methods: 55 patients with ulcerative colitis, even 80 with the syndrome of the irritable bowel syndrome with defects of dentitions, have been applied metallic, cement prostheses and having prostheses on the intraosseous of implants. Markers of bone metabolism in the blood serum and in the oral liquid, the proliferating activity of the epitheliocytes of periodontium have been evaluated according to the morphometric indices of the markers of the proliferation of ki-67, cyclein D1, the inhibitor of apoptosis of bcl-2 have been inspected. Results: Connection of intensity of periodontitis with the stage of colon disease has been stated. Metallic dental prostheses have been served as additional risk factors of development of parodontal diseases in patients with ulcerative colitis. Conclusion: The diagnostic value of the markers of proliferation has been determined in diagnostics of parodontal disease during the application of prostheses from different materials.

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Irritable bowel syndrome as a biopsychosocial disease (review)

Year: 2012, volume 8 Issue: №2 Pages: 232-237
Heading: Internal Diseases Article type: Review
Authors: Burulova О.Е., Kozlova I.V., Myalina Yu.N.
Organization: Saratov State Medical University
Summary:

The research work is devoted to irritable bowel syndrome (IBS) as an independent nosological unity of modern gas-troenterology. Risk factors, clinical manifestations and diagnostic methods of IBS have been analyzed. Psychological and social characteristics in the development of IBS have been examined

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Pathology of digestive organs at adiposity (review)

Year: 2011, volume 7 Issue: №4 Pages: 851-856
Heading: Internal Diseases Article type: Review
Authors: Anisimova E.V., Kozlova I.V., Volkov S.V., Meshcherjakov V.L.
Organization: Saratov State Medical University
Summary:

The review is devoted demonstration of communication of adiposity with occurrence of diseases of digestive organs. The problem urgency is caused by steady increase in number of patients with adiposity, involving in pathological process of vitals. Clinical changes from digestive organs at patients with adiposity can be the diversified, presence « two-dimensional syndromes», caused multiorgans a pathology is characteristic

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