Saratov JOURNAL of Medical and Scientific Research

Shatokhina E.A.

Central State Medical Academy of the ADP of the Russian Federation, Associate Professor at the Department of Dermatology and Venereology and Ccosmetology, Candidate of Medical Science

Immunopathogenetic mechanisms of skin toxic response of antitumor therapy with mul-tikinase of angiogenesis inhibitors

Year: 2017, volume 13 Issue: №3 Pages: 605-611
Heading: Dermatovenerology Article type: Review
Authors: Shatokhina Е.А., Kruglova L.S.
Organization: Central State Medical Academy of the ADP of the Russian Federation
Summary:

The violation of the angiogenesis is associated with pathogenesis of many diseases, but especially pronounced pathological angiogenesis underlies the growth of tumors and metastasis. The physiological control of the angiogenesis is carried out by many growth factors, one main factor — the vascular endothelial growth factor (VEGF), realizing their effects by receptors — proteinkinases. The target therapy of various neoplastic diseases, based on the suppression of angiogenesis, aimed at blockade of receptors for VEGF and other pro-angiogenic growth factors. However, the medicine blockade of receptors for growth factors and suppression of tumor angiogenesis leads to inappropriate exposure are the main cells of the dermis — fibroblasts. As a result of changing the regulatory mechanisms of inhibition of the physiological renewal of epidermis, suppression of angiogenesis and repair when damaged skin there are various skin toxic reactions that are dependent on receptor targets of angiogenesis inhibitors. The study of the mechanisms of adverse events of targeted therapy is an important way of oncoimmunology and dermatology, which will further help to determine the optimal scheme of correction of dermal toxicity and maximize the effectiveness of the antitumor therapy.

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Analysis of the genes polymorphisms distribution of the MMP1, XRCC1, HFE (2), GSTT in patients with non-neoplastic melanin hyperpigmentation

Year: 2017, volume 13 Issue: №3 Pages: 590-594
Heading: Dermatovenerology Article type: Original article
Authors: Ikonnikova EV, Kruglova LS, Shatokhina EA, Talybova AM.
Organization: Central State Medical Academy of the ADP of the Russian Federation
Summary:

Objective: to study the factors of increased risk of hyperpigmentation, with the polymorphism of MMP1, XRCC1, HFE (2), GSTT genes and analysis of their association in patients with various clinical forms of non-neoplastic melanin hyperpigmentation. Material and methods. The study included 38 patients with hyperpigmentation (melasma / chlo-asma, post-traumatic/ post-inflammatory hyperpigmentation, solar lentigo). All patients were underwent buccal swabs with sterile cotton buds to take the material for the study. All patients were underwent genetic analysis of polymorphism of HFE (2), XRCC1, MMP1, and GSTT genes by genotyping single-nucleotide substitutions. Results. In patients with melasma / chloasma, the high value of the alleles cipher of MMP1, XRCC1, and GSTT genes was noted, while the cipher of HFE (rs1799945) and HFE (rs1800562) allele index showed average values. In patients with post-traumatic / post-inflammatory pigmentation, the high value ofthe alleles cipher of MMP1, HFE (rs1799945) and HFE (rs1800562), GSTT genes was noted, while XRCC1 allele cipher showed average values. In patients with solar lentigo, the high value ofthe alleles cipher of MMP1, XRCC1, and GSTT genes was noted, while the cipher of HFE (rs1799945) and HFE (rs1800562) allele index showed average values. Conclusion. Was revealed the similarity ofthe results of genetic research in patients with melasma / chloasma and in patients with solar lentigo.

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