Saratov JOURNAL of Medical and Scientific Research

Kiseleva O.A.

Saratov State Medical University, Department of Polyclinic Therapy, Post-graduate

Modifications of trabeculectomy in glaucoma treatment

Year: 2018, volume 14 Issue: №4 Pages: 831-833
Heading: Ophtalmology Article type: Original article
Authors: Kiseleva О.А., Bessmertny A.M., Suleiman Е.А., Lugovkina K.V.
Organization: Moscow Helmholtz Research Institute of Eye Diseases
Summary:

Purpose: to study efficacy of new trabeculectomy modifications for surgical treatment of primary open- angle glaucoma (POAG). Material and Methods. 49 patients with POAG (49 eyes) aged 51-73 years underwent modified surgery. The main technique of first new modification includes preparation of scleral flap, excision of trabecular tissue along the scleral spur, torsion of scleral flap for 180° and reposition of scleral flap in its original bed secured with interrupted nylon sutures (group 1). The main technique of second new modification includes preparation of scleral flap, excision of trabecular tissue, sewing of scleral flap in the middle with resorbable thread and tightening it into folds. Reposition and fixation of scleral flap and conjunctival flap closure completes the operation (group 2). The efficacy of new modifications of trabeculectomy was assessed during 12 months using complete ocular examination, optical coherence tomography of the anterior segment of the eye (ASOCT) in the early postoperative period and ultrasound biomicroscopy (UBM) subsequently. Results. One month after the surgery average intraocular pressure (ave. IOP) was 10.1±1,9 mmHg in group 1 and 11.2± 1.8 mmHg in group 2 (M±a). At 6 months this parameter was 12.6±3.0 mmHg (group 1) and 13,3±2,7 mmHg (group 2). At 12 months ave. IOP was 15.9±4.1 mmHg (group 1)and 17.3±2.7 mmHg (group 2). Conclusions. The newly developed modifications of trabeculectomy allow to obtain a prolonged hypotensive effect after surgical treatment of POAG.

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Surgical method for prevention of scaring in conducting sinustrabeculectomy

Year: 2017, volume 13 Issue: №2 Pages: 372-375
Heading: Ophtalmology Article type: Original article
Authors: Zhuravleva A.N., Suleiman Е.А., Kiseleva О.А.
Organization: Moscow Helmholtz Research Institute of Eye Diseases
Summary:

Prolonged hypotensive effect in the postoperative period is one of the main tasks of modern glaucoma surgery. In connection with this, the aim of our study is to develop a surgical method of prevention of scarring during the classical sinustrabeculectomy. Material and Methods. The operation was performed in 13 patients (13 eyes) with primary open angle glaucoma (POAG) ll-lll (B-C) in steps aged 50-70 years. The duration of observation up of 2 year. Results. After 9-12 months of hypotensive efficacy was 100% (13 eyes) in 20-24 months — 98% (12 of 13 eyes). The result was confirmed using standard methods of examination (visometry, tonometry, computerized perimetry, tonography et al.), in the early postoperative period was performed optical coherence tomography of the anterior segment, then — ultrasound biomicroscopy. Conclusions. Developed a new version of the surgical treatment of glaucoma a long-acting hypotensive effect.

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Interferon Tiloron Inductor Usage in Complex Therapy at Patients with Community-Acquired Pneumonia

Year: 2009, volume 5 Issue: №2 Pages: 187-190
Heading: Internal Diseases Article type: Original article
Authors: O.A. Kiseleva, G.N. Shemetova, N.B. Zakharova
Organization: Saratov State Medical University
Summary:

The article presents the research findings concerning the importance of changes of the contents in blood serum of interferon gamma (INF-?), interferon alfa (INF-?), the tumor necrosis factor alfa (TNF-?), interleukin 4 (IL-4), interleukin8 (IL-8) and clinical parameters at patients with community-acquired pneumonia before the end of treatment (basic therapy and with immunomodulator tiloron). Tiloron positive influence on clinical manifestations and immunological parameters (profile of cytokines– IL-4, IL-8, INF-?, INF-? and INF-?) has been detected in patients with slightly complicated community-acquired pneumonia in 95 % of cases.

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