Saratov JOURNAL of Medical and Scientific Research

diabetic macular edema

Experience of antiangiogenic and corticosteroid therapy of a diabetic macular edema

Year: 2017, volume 13 Issue: №2 Pages: 383-388
Heading: Ophtalmology Article type: Original article
Authors: Kamenskikh T.G., Batishcheva Yu.S., Kolbenev I.O., Tsipyashchyk A.F., Andreychenko O.A., Gileva E.M., Vasil'yeva T.V., Zakharova N.B.
Organization: Saratov State Medical University

Diabetic macular edema (DME) is a leading cause of blindness in patients with diabetes. The purpose of the research is to evaluate the effectiveness of treatment of patients with DMOs resistant to the administration of ranibi-zumab, using the intrauritreal implant "Ozurdex". Material and Methods. 66 patients (98 eyes) are examined. All of the patients were divided, into three groups, depending on a stage of a diabetic retinopathy. The patients underwent a complex of examinations: along with traditional methods, optical coherence tomography, fluorescence angiography of the fundus, multifocal electroretinography, determination of the content of VEGF-Aand cytokines in serum were used. Results. According to ОСТ of a retina and a visometry there are differences in efficiency of treatment depending on a condition balance of cytokine. Conclusion. The use of the intrauretic implant "Ozurdex" was more effective in patients with DMO in the stage of p re-pro I iterative diabetic retinopathy and in patients resistant to anti-VEGF therapy.

2017_02-1_383-388.pdf2.1 MB

Analysis of the coagulates intensity in laser treatment of diabetic macular edema in a Navilas robotic laser system

Year: 2017, volume 13 Issue: №2 Pages: 375-378
Heading: Ophtalmology Article type: Original article
Authors: Zamytskiy Е.А., Zolotarev A.V., Karlova E.V., Zamytskiy P.A.
Organization: Samara Regional Clinical Ophthalmological Hospital n.a. T. I. Broshevskiy, Samara State Medical University

The aim ofthisworkwasto analyze the intensity of the laser coagulates in the treatment of diabetic macular edema conducted in navigation mode on robotic laser system Navilas. Material and Methods. Retrospective analysis of outpatient cards and photographs of the fundus 20 patients (28 eyes) had been done. The patients had type II diabetes mellitus. We performed laser treatment of diabetic macular edema. There were evaluated 4260 coagulates, of which 0 degree 2166 (50.85%), I degree —525 (12.32%), II degree —747 (15.74%), III degree—498 (11.96%), grade IV — 324 (7.6 per cent). Result. The thickness of the retina before treatment in the area of edema was made 339.72±45.3 urn, and after treatment 346±70 urn, student's t-test 0.7124, a difference of 6.5±57.4. Visual acuity before treatment 0.532±0.3, after— 0.521±0.3mm, student's t-test 0,889. Conclusion. The facts obtained in the analysis suggests that the algorithm of selection of power and the way it adjustments in the course of treatment are the weak point of this technique. Development of new methods, giving the possibility to adjust the power depending on the height of the swelling region of the retina, thereby gaining coagulates strictly necessary for the specific case of intensity, will enable to increase the efficiency and safety of laser treatment.

2017_02-1_375-378.pdf265.71 KB