Saratov JOURNAL of Medical and Scientific Research


Modern approaches to treatment of uveitis in systemic diseases of connective tissue

Year: 2018, volume 14 Issue: №4 Pages: 956-960
Heading: Ophtalmology Article type: Review
Authors: Kamalova K.B., Zakirkhodjayev R.A., Asrorkhodjayeva I.R.
Organization: Tashkent Medical Academy

 Uveitis can develop in various systemic diseases of connective tissue. This article provides data on modern methods of treatment for such cases of uveitis. Uveitis in systemic diseases of the connective tissue develops due to violations of cellular and humoral immunity. Given the pathogenesis of the primary disorder, treatment of uveitis in systemic diseases of connective tissue involves use of cytotoxic drugs, TNFa inhibitors, cytokines, antibodies to lymphocyte surface antigens, and immunoglobulins. Due to the chronic course of the disorder and frequent relapses, it is advisable to use local and systemic glucocorticoid drugs with prolonged effect. The combined corticosteroid drug diprospan containing the two active ingredients of betamethasone provides a combination of immediate and prolonged effects, thereby improving patient's clinical condition and prolonging the period of remission.

2018_4-2_956-960.pdf274.46 KB

Occurrence and features of uveitis in patients with rheumatic diseases: current peculiarities of clinical examination and patient management.

Year: 2017, volume 13 Issue: №2 Pages: 358-361
Heading: Ophtalmology Article type: Original article
Authors: Dzhalavyan Y.V., Kamenskikh T.G., Gamayunova K.A., Gaydukova I.Z.
Organization: Saratov State Medical University

The objectives of the study are to establish the occurrence of uveitis in patients with rheumatic diseases, to assess the features of the uveitis in rheumatic disease in children and adults, and to analyze the effectiveness of theirtreatment. Materials and Methods. The study included 670 people with RH (stage I) and 35 patients who had uveitis and / or rheumatic fever who agreed to undergo additional ophthalmologic bleeding (stage II), including a standard ophthalmological examination including visiometry, biomicroscopy of the anterior segment, ophthalmoscopy of the posterior segment of the eye, refractometry, optical coherence tomography in angiomode(tomograph-angiograph CIRRUS HD-OCT MODEL 5000 (Carl Zeiss, Germany), dopplerography of the vessels of the eye. Results. The prevalence of uveitis in rheumatic diseases was established in 21%, which is higher than that in the general population. Uveitis in rheumatic diseases is recurrent and well-treated condition with frequent and complete improvement of visual acuity, and angiographycal features of uveitis, p <0,05 for all parameters. Conclusions. The high incidence of uveitis and relapsing their course in rheumatic diseases lead to necessity of an ophthalmologist's examination every 6 months. It is desirable to perform a comprehensive angiographic examination of uvea for the timely detection of erased and subclinical forms of uveitis.

2017_02-1_358-361.pdf266.04 KB