Saratov JOURNAL of Medical and Scientific Research

chemical burns

Effectiveness evaluation of application of niosomal gel "Regenerin" in the treatment of chemical burns of cornea

Year: 2017, volume 13 Issue: №2 Pages: 216-220
Heading: Microbiology Article type: Original article
Authors: Bazikov I.A., Botasheva V.S., Kalinkina N.I., Maltsev A.N., Kostyukova N.Yu., Domenyuk D. A.
Organization: Stavropol State Medical University
Summary:

The aim of the work was to study the effectiveness of using the ophthalmic gel "Regenerin" in the treatment of a simulated chemical burn of the cornea in an experiment. Material and Methods. The chemical composition of the drug "Regenerin" was studied by mass spectrometry The regenerative action of the niosomal gel, including low molecular weight peptides extracted from placental cells and encapsulated, was then studied in 40 organisms of 20 rabbits of the chinchilla breed with a 10% solution of caustic soda. The subjects of the study are divided equally into two groups: in the experimental group, the treatment was carried out by applying a gel to the burn surface, the therapy was not performed in the control group. Results. The result of treatment with the "Regenerin" Ophthalmic Gel is a significant reduction in the timing of reparative regeneration in the animals of the experimental group due to increased metabolism and corneal neovascularization processes. Conclusion. The combined effect of these mechanisms, manifested in the arrest of edema, resorption of inflammatory infiltrates, normalization of the integrity of the endothelium, epithelial layer and basal membrane leads to completely restoring the histological structure of the cornea on the seventh day.

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2017_02_216-220.pdf663.73 KB

Effectiveness evaluation of application of niosomal gel "Regenerin" in the treatment of chemical burns of cornea

Year: 2017, volume 13 Issue: №2 Pages: 216-220
Heading: Microbiology Article type: Original article
Authors: Bazikov I.A., Botasheva V.S., Kalinkina N.I., Maltsev A.N., Kostyukova N.Yu., Domenyuk D. A.
Organization: Stavropol State Medical University
Summary:

The aim of the work was to study the effectiveness of using the ophthalmic gel "Regenerin" in the treatment of a simulated chemical burn of the cornea in an experiment. Material and Methods. The chemical composition of the drug "Regenerin" was studied by mass spectrometry The regenerative action of the niosomal gel, including low molecular weight peptides extracted from placental cells and encapsulated, was then studied in 40 organisms of 20 rabbits of the chinchilla breed with a 10% solution of caustic soda. The subjects of the study are divided equally into two groups: in the experimental group, the treatment was carried out by applying a gel to the burn surface, the therapy was not performed in the control group. Results. The result of treatment with the "Regenerin" Ophthalmic Gel is a significant reduction in the timing of reparative regeneration in the animals of the experimental group due to increased metabolism and corneal neovascularization processes. Conclusion. The combined effect of these mechanisms, manifested in the arrest of edema, resorption of inflammatory infiltrates, normalization of the integrity of the endothelium, epithelial layer and basal membrane leads to completely restoring the histological structure of the cornea on the seventh day.

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2017_02_216-220.pdf663.73 KB