insulin resistance

Humanism and mercy, loyalty to the principles of medical service to the patient have always constituted the ethical and moral basis of Russian medicine. These qualities were especially clearly manifested in the exploits of medical staff during the Great Patriotic War. An appeal to the moral heritage of military doctors is one of the ways to preserve the traditions of Russian medicine in modern society.

The adipose tissue is the endocrine organ secreting polypeptide factors, such as adipokines, which are involved in the regulation of feeding behavior, the metabolic, endocrine and inflammatory processes and insulin sensitivity. In obesity and type 2 diabetes mellitus (DM2), the production of adipokines and the activity of their signaling pathways are changed, which plays an important role in the relationship between obesity, insulin resistance and DM2. In the review (according the types of obesity) the data on the production of adipokines with diabetogenic (leptin, visfatin, chemerin, vaspin, apelin, resistin) and antidiabetic (adiponectin, omentin) properties by the adipose tissue, as well as the possible role of adipokines in the development of obesity and DM2 were discussed.

The literature review is devoted to the universal molecular markers and predictors of forming non-alcoholic fatty liver disease and pathology of the colon, the role of insulin resistance as one of the factors of the pathogenesis of non-alcoholic fatty liver disease in the development of colorectal cancer. The mechanisms of diseases of the colon (colorectal cancer) are found out to be due to non-alcoholic fatty liver disease.