Saratov JOURNAL of Medical and Scientific Research

Uralsk State Medical Academy

Heart rate variability, structural and functional characteristics of the left ventricle in essential arterial hypertension

Year: 2010, volume 6 Issue: №3 Pages: 600-605
Heading: Internal Diseases Article type: Original article
Authors: Khromtsova О.М.
Organization: Uralsk State Medical Academy

For the purpose of diagnostic and treatment improvement it is necessary to investigate relationship between different pathogenetic mechanisms in essential hypertension. The aim of our study was the comparative analysis of the parameters of cardiac remodeling and neurohumoral mechanisms of heart rate variability (HRV) in patients with essential arterial hypertension. 100 patients with essential arterial hypertension were included in the study. All patients went through heart rate variability parameters and left ventricle characteristics evaluation. Time and frequency domains were decreased in patients with arterial hypertension. Excess sympathetic activation takes place, parasympathetic system is depressed and it shows pathogenetic basis of disadaptation. Left ventricle hypertrophy is associated with progressive decrease of HRV and its circadian fluctuations. Concentric left ventricle hypertrophy is characterized by the most significant decrease in time and frequency domains of HRV. 1/3 of hypertensive patients with normal left ventricle geometry have diastolic dysfunction and also some decrease in time and frequency domains. In conclusion, we found that cardiac remodeling in patients with essential hypertension seems to be related to the severity of impairment of cardiac autonomic control

201003_600_605.pdf292.76 KB

Structure Of Muscular Parts of Interventricular Septum of the Heart Human Fetal

Year: 2009, volume 5 Issue: №2 Pages: 155-159
Heading: Macro- and Micromorphology Article type: Original article
Authors: A.A. Yakimov
Organization: Uralsk State Medical Academy

Interventricular septum (IS) has been studied in ordinary formed human fetal hearts (20–28 weeks) by means of the anatomo-metrical method. VS breadth appears to be less than its length, but is more than the breadth of the medial walls of both ventricles. The outlet length surpasses the inlet one more on the right than on the left septal side. On transversal sections the angle between IS departments is 122 — 139°. The angle degree increases from the basis to the apex of the heart. The angle between the longest axes of the right surface divisions is 38 — 42°. The length proportions of the IS departments become constant to the middle fetal period. The sinus part of the IS is square or multiangular (often four- or five-angular) and along the bloodstream. The development of the sinus part is coordinated with formation of the inlet trabecular part. The conal part is the smallest one. The conal development in the middle fetal period has not been completed yet. Size proportions of the IS parts and departments seem to be much the same in the normal fetal and newborn hearts.

200902_155_159.pdf1.21 MB