Saratov JOURNAL of Medical and Scientific Research

Sedov D.S.

Saratov State Medical University n.a. V. I. Razumovsky Post-graduate of Department of Internal Medicine of Medical Faculty

Cardiac remodeling in patients with chronic kidney disease

Year: 2019, volume 15 Issue: №2 Pages: 217-221
Heading: Internal Diseases Article type: Review
Authors: Sedov D.S., Rebrov А.Р.
Organization: Saratov State Medical University
Summary:

The duration and quality of life of patients undergoing extracorporeal renal replacement therapy are largely dependent on concomitant diseases and conditions. Cardiovascular disease is a significant complication of chronic kidney disease and a major cause of death in patients undergoing hemodialysis. Cardiovascular remodeling is an independent predictor of the risk of cardiovascular events in patients with chronic kidney disease (CKD), including those in the dialysis stage. This paper analyzes the literature on left ventricular myocardial remodeling in the late predialysis stages of CKD and in patients receiving treatment with chronic hemodialysis.

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Dynamics of laser speckle imaging of blood flow in the tissues at partial temporary pancreatic ischemia of hungry, fed and alcoholized rats

Year: 2016, volume 12 Issue: №2 Pages: 106-109
Heading: Macro- and Micromorphology Article type: Original article
Authors: Alexandrov D.A., Timoshina P.A., Tuchin V.V., Maslyakova G.N., Palatova T.V., Sedov D.S., Izmailov R.R.
Organization: Saratov State Medical University
Summary:

The aim of the study is to determine the influence of a partial temporary ischemia and reperfusion on the development of pancreatitis in laboratory rats. Material and Methods. The experiments were performed on 73 white rats. Occluded blood vessels and blood flow were recorded by digital biomicroscopy and laser speckle contrast imaging. Statistical data processing was carried out the program Statistica for Windows 6.0 using the Student's criterion. Results. Laser speckle imaging and digital microscopes provide the monitoring of blood flow in the vessels of the pancreas. After a five-minute partial ischemia reactive hyperemia occurs, changes are invertible. After a twenty-minute partial ischemic reactive hyperemia does not occur, without developing pancreatitis necrosis. Pancreas of alcoholized rats has been found out to be more sensitive to ischemia. Conclusion. The method of laser speckle imaging and intravital microscopy after digital five- and twenty-minute partial ischemia of the pancreas revealed phase opposite directed changes in its tissue perfusion and varying severity of postischemic pancreatitis.

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The clinical significance of the prevalence of parapancreatitis in pan-creonecrosis

Year: 2016, volume 12 Issue: №1 Pages: 57-60
Heading: Surgery Article type: Original article
Authors: Alexandrov D.A., Tolstokorov A.S., Sedov D.S.
Organization: Saratov State Medical University
Summary:

Tftea/m of the study is to determine the relationship of clinical surgical treatment options of degradation of retroperi-tonealfat. Material and Methods. We have analyzed the results of treatment of 1177 patients with necrotizing pancreatitis, taking into account the severity and characteristics of parapancreatitis. Statistical data processing was carried out by the program Statistica for Windows 6.0. using the Student's criterion. Results. The variety of clinical forms of pancreatic necrosis due to a combination of options lesions of the pancreas and retroperitoneal fat. The outcome of pancreatic necrosis is determined not only by the degree of destruction of the pancreas, but also features parapancreatitis. The allocation of limited and common prevalence of parapancreatitis was substantiated and specified. Conclusion. The effectiveness of the treatment of pancreatic necrosis is dependent on the development options of parapancreatitis which present the predictive and tactical value.

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