Akhmadeeva L.R.

The aim of the study is to evaluate the neuroprotective effect of xanthohumol (XN) on experimental models of acute ischemic stroke in vivo and in vitro. Material and Methods. Middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation (OGD) are used as an in vivo and in vitro model. The object of the study is Sprag-Dawley rats, which are randomly divided into three groups: a control group; two groups operated by MCAO with and without XN. Primary culture of cortical neurons was obtained from newborn rats. We use the Bederson test and the angle test to evaluate neurological disorders. Results. Preliminary results indicate a possible cerebroprotective effect of XN in an ischemic stroke model. Conclusion. Prophylactic administration of xanthohumol before cerebral ischemia in an experiment can effectively reduce the volume of cerebral infarction and improve neurological deficiency 24 hours after MCAO

We present information about Ohtahara II syndrome which is a rare epileptic encephalopathy, and our own clinical
case: a 4-year old child with this disorder.

Aim: analysis of the current status and evaluation of the effectiveness of rehabilitation measures for patients with impaired motor function in the early recovery period of cerebral stroke in the conditions of a specialized inpatient department. Material and methods. The data of the state of patients with motor deficit after a cerebral stroke were analyzed in the rehabilitation department from November 2016 to March 2017. Results. During the study period, the effectiveness of the rehabilitation department for patients in the early recovery period of cerebral stroke was assessed. Improvements in cognitive functions were detected in these patients, and these patients also have a high potential for self-esteem of the social significance of the disease and the condition (anxiety and depression) at the time of being in the inpatient rehabilitation department. Conclusion. The presented data testify to the need to take into account the characteristics of patients in the early recovery period of cerebral stroke in the development of rehabilitation activities within the inpatient department.

A literature review on evaluation of postural function in elderly patients is presented in the article. The detailed description of the main methods of diagnostics of balance disorders is given in the work.

The purpose of this work is to define the clinical and social predictors of headaches in children and adolescents. Material and Methods. We performed clinical examination of children and adolescents, which included studying their symptoms, anamnesis, somatic and neurological objective signs, survey using our original questionnaire and survey in the framework of an international project to study headaches «World Children and Adolescent Headache Project». The type of headache was diagnosed using international diagnostic criteria of the International Classification of Headache Disorders, 3rd edition (beta release). As a result of our study, we obtained the data about the most significant lifestyle factors (among those studied) influencing the number of days with headache per month, calculated linear coefficients and a predicting mathematical model for children. The sensitivity of the model for the prognosis of chronic tension type headache is 63%, specificity — 81 %. Conclusion. In this paper we describe criteria for the prognosis of primary headaches in patients aged from 8 to 18 years old.