Saratov JOURNAL of Medical and Scientific Research

juvenile hemangioma

Antiangiogenic properties of beta-blockers

Year: 2018, volume 14 Issue: №4 Pages: 728-734
Heading: Dermatovenerology Article type: Original article
Authors: Dubensky VI.V, Dubensky V.V.
Organization: Tver State Medical University of the Ministry of Russia
Summary:

 Objective: determination of comparative antiangiogenic effectiveness and influence of beta-blockers on the level of a vascular endothelial factor of growth in an experiment. Material and Methods. For determination of antiangiogenic effect of beta-blockers, comparative studying of their influence on the level of a vascular endothelial factor of growth in an experiment on 72 nonlinear laboratory rats, by average weight 180±20 g which were conditionally divided into 6 groups is executed: 1st — control, 2nd — negative control (experimental ischemia (El), crossing of femoral vessels), 3rd — positive control (El with bevacizumab introduction), 4th — El with introduction of a timolol, 5th — El with introduction of a betaksolol, 6th — El with introduction of interferon alpha 2b. Results. The VEGF levels were: in 1st group 1.5±0.3 pg/ ml, in 2nd group 20,3±3,2 pg/ml, in 3rd group5,8±0,9 pg/ml, in 4th group 13,8±1,4 pg/ml, in 5th group 192,0±2,3 pg/ml, in 6th group 11,1 ±2,2 pg/ml. Results of microscopy and immunohistochemical research demonstrate lack of activation of processes of neoangiogenesis in 1 st group of animals. At animals of 2nd and 5th groups along with the expressed inflammatory processes the neoangiogenesis phenomena are established. Conclusion: Beta-blockers show the direct or mediated negative impact on synthesis of VEGF and oppression of neoangiogenesis. The activity of selective beta-blocker concerning neoangiogenesis suppression was lower in comparison by activity non-selective that allows to consider the timolol effective antiangiogenic remedy.

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Modern approaches to surgical treatment of juvenile hemangiomas

Year: 2015, volume 11 Issue: №3 Pages: 471-476
Heading: Dermatovenerology Article type: Short message
Authors: Dubensky V.V.
Organization: Tver State Medical University of the Ministry of Russia
Summary:

Aim: studying of clinical and functional features of juvenile hemangioma to identify indications to their removal. Analysis of the nature of side effects at the different methods of treatment and determination of efficiency of the ra-diowave moving away of juvenile hemangioma. Materials and methods. The study involved 216 children with juvenile hemangioma and 14 adult patients with persistent hemangioma. Radiowave treatment was conducted to 32 children with superficial juvenile hemangioma. Results. Superficial juvenile hemangioma are diagnosed in 76.1%, thus the highest prevalence of superficial juvenile hemangioma of small diameter and thickness. At the inspection of children with complications of different methods of treatment of hemangioma found the prevalence of formation of pathological scars, during removing of hemangioma by carbon-dioxide laser and at a scelerotherapy — 58,3%. Swelling and soreness at the radio wave moving away at most patients (84,3%) passed through 3 days, recovery after a 1 session came at 65,6% of patients, after 2 sessions — at 28,2%, after 3 sessions — at 6,2%. At watching the patients of this group during one to three years their proof recovery is set. Conclusion. High postoperative cosmetic effect under strict indications for surgical removal, the absence of relapses and the low percentage of continued growth (6.2% after the second session deletion) allow to recommend high-frequency radio wave removing for the treatment of superficial juvenile hemangioma of the skin.

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