Saratov JOURNAL of Medical and Scientific Research

Sorokina N.V.

Kuban State Medical University, Assistant of the Department of Dermatology

General antioxidant activity of blood of patients with limited sclerodermia and its correction

Year: 2017, volume 13 Issue: №3 Pages: 640-643
Heading: Dermatovenerology Article type: Original article
Authors: Tlish M.M., Sorokina N.V.
Organization: Kuban State Medical University
Summary:

Objective: to increase efficiency and to reduce the time of treatment of patients with circumscribed sclerodermia. Material and Methods. 60 patients with circumscribed sclerodermia were under supervision. Two groups of these patients were formed with method of adaptive randomization. In the comparison group the patients received standard therapy according to the federal clinical guidelines. In the general group the standard complex treatment with additional antioxidant therapy was underwent. The course of treatment in all patients was 21 days. The results of treatment were evaluated in accordance with the dynamics of cutaneous pathological process and the concentration of common an-tioxidants. Results. Based on the obtained results of the assessment of the dynamics of the cutaneous pathological process, it is obvious that the regress of dermatosis was more rapid and more active in the general group and was accompanied by a more pronounced increase in the total antioxidant activity of the blood. Conclusion. The proposed method of treatment, having an antioxidant effect and high clinical efficacy, enhances the general antioxidant activity of the blood and allows reducing the duration of treatment of patients with circumscribed scleroderma and, as a consequence, the course of systemic and local corticosteroid therapy.

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Cytokine markers of the efficiency of correction of oxidative stress in patients with limited sclerodermia

Year: 2015, volume 11 Issue: №3 Pages: 410-414
Heading: Dermatovenerology Article type: Short message
Authors: Tlish M.M., Sorokina N.V.
Organization: Kuban State Medical University
Summary:

Objective: to improve treatment of patients with limited sclerodermia (LSD) by increasing efficiency and reducing the time of their treatment. Material and methods. The examination and treatment of 52 patients with circumscribed scleroderma were conducted. Two groups of these patients were formed with method of adaptive randomization. In the control group complex treatment was underwent according to the standards in this nosology. In the general group the patients additionally received antioxidant therapy. The course of treatment was 21 days in both groups. Results. Treatment results were evaluated in accordance with the dynamics of cutaneous pathological process and cytokine profile. In the course of treatment positive clinical dynamics in patients of the study group went faster and was accompanied by a more pronounced reduction in inflammatory activity in the blood serum. Conclusion. The results suggest that antioxidant therapy improves the efficiency and reduces the treatment time of patients with circumscribed sclerodermia.

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