Saratov JOURNAL of Medical and Scientific Research

Nikolashina О.E.

Penza Regional Clinical Center of specialized types of medical care, Head of the Department.

On the relationship between innate and adaptive immunity in psoriasis

Year: 2015, volume 11 Issue: №3 Pages: 421-423
Heading: Dermatovenerology Article type: Review
Authors: Nikolashina О.Е., Bakulev A.L.
Organization: Penza Regional Clinical Center of specialized types of medical care, Saratov State Medical University
Summary:

There is an overview of the current literature data, which reflects the key aspects of the etiology and pathogenesis of psoriasis. A genetically determined, multifactorial nature of the dermatosis was displayed. There were summarized numerous domestic and foreign data on immunological (cellular, humoral, mediator, extravasation, angiogenesis) and non-immune mechanisms of genesis of psoriasis.

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Comparative clinical laboratory evaluation of leflunomide and narrow-band medium wave ultraviolet therapy for psoriasis

Year: 2015, volume 11 Issue: №3 Pages: 389-392
Heading: Dermatovenerology Article type: Short message
Authors: Nikolashina О.Е.
Organization: Penza Regional Clinical Center of specialized types of medical care
Summary:

Objective: to compare the clinical and laboratory evaluation of the efficacy of leflunomide and narrow-band medium wave UV therapy in patients with psoriasis. Material and methods. 60 patients with psoriasis. The patients were divided into 2 groups depending on the treatment. Patients of group 1 (30 patients) administered narrowband medium wave UV therapy — 20 procedures. Group 2 patients (30 persons) received leflunomide in combination with narrow-band medium wave UV-therapy. To evaluate the effectiveness of therapy studied cytokine profile. Results. Patients treated with leflunomide combined with phototherapy, marked a significant shift of the studied parameters and clearer resolution of lesions on the skin. Conclusion. The use of leflunomide in patients with psoriasis in combination with narrow-band medium wave UV therapy promotes a more definite resolution of psoriatic lesions on the skin and a significant improvement in quality of life, as well as the normalization of peripheral blood cytokine profile.

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