bone tissue metabolism

The aim: is to study the peculiarities of paraimplant inflammation pathogenesis after primary knee arthroplasty on the basis of dynamic changes of humoral immunity markers and bone tissue metabolism. Material and Methods. Research object includes 140 cases: 50 patients with paraimplant inflammation make up the main group; 30 patients with early aseptic instability make up the first experimental group; 30 patients undergoing primary arthroplasty make up the second experimental group; 30 conditionally healthy blood serum donors make up the control group. We determined the content of humoral immunity markers (circulating immune complexes binding C3d and containing IgG, triggering receptor expressed on myeloid cells) and bone tissue metabolism (tumor necrosis factor a, interleukin 1 (3, bone isoen-zyme of alkaline phosphatase) by the method of hardphase immune-enzyme analysis in all the groups. Results. We noticed elevated activity of circulating immune complexes binding C3d and containing IgG, triggering receptor expressed on myeloid cells, proinflammatory cytokines and alkaline phosphatase in blood serum of patients with paraimplant inflammation; proinflammatory cytokines and alkaline phosphatase — in patients with early aseptic instability; there were no changes in the studied indicators- in patients undergoing primary arthroplasty. Conclusion. Increased expression of triggering receptor expressed on myeloid cells causing release of proinflammatory cytokines and also elevated activity of circulating immune complexes binding C3d and containing IgG and bone isoenzyme of alkaline phosphatase play a significant role in paraimplant inflammation pathogenesis after primary knee arthroplasty.

Purpose: an assessment of efficiency of complex treatment of periodontitis at women in a period of postmenopause with the use of zoledronic acid. Material and methods. Examination and treatment of 90 patients with a chronic generalized periodontitis against post-menopausal osteoporosis has been conducted. Material is processed statistically. Results. Application of preparations of zoledronic acid in complex treatment of system osteoporosis and periodontitis allows to reduce the frequency of recurrence of periodontal disease and to improve indicators of bone remodeling. Conclusion. In conclusion it is worth while determining that zoledronic acid in complex therapy of periodontitis is an effective method of drug correction of a mineral exchange before periodontological surgery.