Saratov JOURNAL of Medical and Scientific Research

Ivanov A.A.

Federal Medical and Biophysical Center n.a. A.I. Burnazyan, Head of the Laboratory of radiation immunology and experimental therapy of radiation injuries, Joint Institute for Nuclear Research, Leading Scientific Researcher, Institute of Biomedical Problems, Russian Academy of Sciences, Head of the Laboratory of radiobiology of heavy ions, Professor, Doctor of Medical Sciences

Effects of the vaccine "Grippol" on resistance of mice after irradiation by protons

Year: 2015, volume 11 Issue: №4 Pages: 656-658
Heading: radiation medicine Article type: Short message
Authors: Ivanov А.А., Abrosimova A.N., Bulinina Т.М.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Aim: to investigate the effect of the vaccine "Grippol" on radioresistance with respect to proton irradiation. Material and methods. The effect of the vaccine "Grippol" the survival of the animals was studied in mice CBAxC57BI F1, which was immunized for 10 days prior to proton irradiation. Results. It is shown that proton irradiation causes the death of the animals at all doses tested: 9% at a dose of 7.0 Gy; 10% — 8.0 Gy and 33% after irradiation at a dose of 8.5 Gy, at the same time the survival rate after pre vaccination study groups was 100%. It seems appropriate to further study the impact of the vaccine "Grippol" at low doses of proton irradiation using appropriate test evaluation of hematological, im-munological, genetic, physiological and other factors. Conclusion. The vaccine "Grippol" introduction into mice before lethal proton irradiation increases survival of protected animals.

Effect of individual and group housing of mice on the level of radioresistance

Year: 2015, volume 11 Issue: №4 Pages: 653-656
Heading: radiation medicine Article type: Original article
Authors: Dorozhkina O.V., Bulynina Т.М., Ivanov А.А..
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Aim: to examine the effect of individual and group housing of mice on radioresistance. Material and methods. Effects of individual and group housing of mice on immunity and blood systems were studied on ICR (CD-1) and C57BI6 male mice before and after proton irradiation. Results. Group housing of intact animals resulted in a decline in the number of nucleated cells in the femur bone marrow and thymus mass. The irradiation with proton with energy of 171 MeV at a dose of 1 Gy causes a statistically significant greater reduction of the number of nucleated cells in the femur bone marrow in group-housed mice. A trend toward greater safety of the number of leukocytes in the peripheral blood and higher proliferative activity of bone marrow cells, as well as lower level of aberrant mitoses have been noted in individually-housed mice. Reduction processes in the recovery period of radiation sickness take place at a greater rate in group-housed mice. Conclusion. Group housing of male mice causes increased sensitivity of the blood and immunity systems to the effects of radiation and at the same time accelerates processes of radiation recovery.

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Antiradiation properties of melanin

Year: 2014, volume 10 Issue: №4 Pages: 828-832
Heading: radiation medicine Article type: Original article
Authors: Bushmanov A.Ju., Ivanov А.А., Andrianova I.E., Stavrakova N.M., Bulinina T.M., Dorozhkina O.V.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Aim: to examine the therapeutic efficiency of melanin administered to mice after irradiation at lethal and sublethal doses. Material and methods: Survival and hematological states were studied on CD-1 mice receiving on acute or fractionated whole-body doses on X-rays or gamma-irradiation. Melanin soluble was given with water ad libitum from the first to the 30th-day after irradiation. Results. It was shown that melanin produced a significant therapeutic and protective-therapeutic action against acute radiation injury in the dose range 6,5-7,5 Gy (LD80-LD under our conditions). Cumulative survival melanin treated mice was increased to 14,4%, in control group — 1,9%. After fractionated injury (1 Gy daily, total dose 10 Gy) all mice which consumed melanin remained alive, versus 43,7% in control. Melanin decreased radiation-induced damage and stimulated the hematopoiesis recovery after sublethal exposure (5Gy). Conclusion. The results permit to regard melanin as a therapeutic agent for treatment of radiation injuries.

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