Saratov JOURNAL of Medical and Scientific Research

immunogenetic markers

The actual conception of development and pathology of fetal testes

Year: 2015, volume 11 Issue: №4 Pages: 511-514
Heading: Macro- and Micromorphology Article type: Review
Authors: Maslyakova G.N., Palatova T.V., Serkova А.А.
Organization: Saratov State Medical University

The actual problem recently determined is concerned with the reproductive disorders in men. Male infertility results from a variety of pathological processes in the body. It is known that most anomalies of organs of reproductive system develop in the period of prenatal ontogenesis. The review provides the data on embryogenesis of fetal testes and factors that can lead to disturbances in the formation of the testes and male infertility.

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Immunogenetic markers of Crohn's disease in adults population of the Moscow region

Year: 2014, volume 10 Issue: №4 Pages: 743-749
Heading: Genetics Article type: Original article
Authors: Stavtsev D.S., Astrelina Т.А., Azova M.M., Lebedeva L.L., Pukhlikova T.V., Chumak A.A., Knyazev O.V., Eremin I.I., Gilmutdinova I.R., Kotenko K.V.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency, Peoples' Friendship University of Russia, Blood transfusion station of the Department of Health of the City of Moscow

Aim: to study immunogenetic markers of predisposition to the development and protection for Crohn's disease in adults population of the Moscow region. Material and methods. The study included 53 samples of peripheral blood of patients with Crohn's disease in the Moscow region. The control group was represented by 1,700 samples of umbilical cord blood is healthy newborns. Revealing HLA antigens at low level performed by SSO method on DynalRELI 48 processor. The results received with ambiguous interpretation was using PCR-SSP method (Ivitrogen). Results. Were found the positive and negative associations of groups of HLA alleles with clinical form, the course of Crohn's disease and response to steroid treatment, in particular revealed that, predisposition to the development for Crohn's disease in women and with sensitivity to steroid treatment in this disease associated allele group C*12, to the characteristic restricting markers such as Crohn's disease include the В 38 and A*11 markers nonrestricting, nonpenetrating noninflammatory type groups are alleles B*56 and C*14 and C*14 is also associated with the risk of Crohn's disease in men, characteristic markers of protection to the development of the disease crown with chronic relapsing and severe clinical course are DQB1*02 and DQB1*03, respectively. Conclusion. These results demonstrate the need for studies of gene polymorphism HLA-system, not only in relation to the disease in general, but in selected patients with clinical groups.

2014_04-01_743-749.pdf1.88 MB