Saratov JOURNAL of Medical and Scientific Research

Morozova T.I.

Saratov State Medical University n.a. V. I. Razumovsky, Head of Department ofPhthisiol-ogy Professor, Doctor of Medical Science

Successful treatment of pulmonary tuberculosis in old age (clinical case)

Year: 2020, volume 16 Issue: №1 Pages: 176-180
Heading: Тhematic supplement Article type: Case report
Authors: Morozova T.I., Salina T.Yu., Semenov S.V.
Organization: Regional Hospital for War Veterans, Saratov, Saratov State Medical University
Summary:

Elderly people are a high-risk group for developing tuberculosis, with difficulties in diagnosis and treatment with an uncertain prognosis. We present a clinical case of tuberculosis with a favorable outcome in a patient aged 86 with a large numerous comorbid pathologies, including an organic brain disease with intellectual and behavioral disorders. This clinical observation demonstrates an atypical course of tuberculosis in the elderly, a slow reverse dynamics of the process and a cure with large residual changes in the lungs.

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Prognosis of development of unfavorable phenomena of chemotherapy in patients with for the first time revealed tuberculosis of lungs

Year: 2015, volume 11 Issue: №4 Pages: 576-582
Heading: Phthisiology Article type: Original article
Authors: Danilov A.N., Morozova T.l., Doktorova N.P.
Organization: Saratov State Medical University, Saratov Research Institute of Rural Hygiene
Summary:

Aim: development of criteria and a method of prognosing of emergence of adverse side effects to the first mode of chemotherapy at patients with for the first time revealed tuberculosis. Materials and Methods: The analysis of the collateral reactions (CR) on tubercular preparations has been carried out at 214 patients receiving treatment at the first mode of chemotherapy. During the treatment an indicator of quality of life by a technique the DIGNITY (health, activity, mood), a condition of intersystem interaction of respiratory and cardiovascular systems of an organism (Hildebrant's coefficient), a vegetative index of Kerdo were estimated at patients. Results. Ufavorable effects on PTP develop at every third patient (33,6%). The CR different types depends on the age and availability of the accompanying pathology. Allergic reactions develop at patients with existence of endocrine pathology (27,8%) authentically more often, toxic — at patients with defeats of nervous system (56,3%). Extent of change of an index of Kerdo of 59,4±2,4%, Hildebrant's coefficient 48,9± 1,6% in the first 4 weeks of treatment of the patient corresponds to emergence of CR in the first 3 months of chemotherapy. Conclusion. Dynamics of coefficient of Hildebrant, Kerdo's index and an indicator of treatment, SAN at the initial stages, are considerably associated with the risk of development of side effects of chemotherapy and were a basis of the developed computer system expert for prognosing the development of these complications. The predictive value of system is 76,3% of sensitivity at 84,7% of specificity.

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Influence of periodicity of fluorographic examination of population on the frequency of occurrence of bacillary excretion and destructive forms of tuberculosis in persons with the firstly diagnosed disease

Year: 2014, volume 10 Issue: №4 Pages: 659-662
Heading: Phthisiology Article type: Original article
Authors: Danilov A.N., Morozova T.I.
Organization: Saratov State Medical University
Summary:

Aim: to establish the structure of the relationship between the change in regulations of fluorographic regimen and frequency of occurrence of bacillary excretion (MBT+), destructive forms of the disease in patients with newly diagnosed tuberculosis. Materials and Methods. 1,428 cases with newly diagnosed tuberculosis — a form №089u-tub, as well as other types of reports of the Saratov region have been analyzed. Statistical analysis has been performed by computer software «Microsoft Excel» and «Statistica-6.0». Analysis of the data by the test of Kolmogorov — Spirin has showed normality of their distribution. Confidence index was assessed by Student's. Differences were assessed as valid if the probability was 95% (P

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Hixozide in therapy of tuberculosis of bronchi

Year: 2014, volume 10 Issue: №2 Pages: 293-300
Heading: Phthisiology Article type: Original article
Authors: Morozova T.l., Barinboym O.N., Doktorova N.P., Danilov A.N.
Organization: Saratov State Medical University
Summary:

The purpose of the article is to evaluate the efficacy and tolerability of the combined inhaled anti-TB preparation Hixozide for improving the effectiveness of medical treatment of patients suffering from tuberculosis of bronchus. Material and Methods. Hixozide (made in Russia), the active substance Hydroxymethylchinoxylindioxydum 100mg + Isoniazidum 250 mg, was delivered via inhalations using a compressor nebulizer within 21 days in the course of the complex chemotherapy. Inclusion criteria: newly diagnosed patients and patients with relapsed tuberculosis with the presence of tuberculousendobronchitis, drug sensitivity saved to isoniazid. Exclusion criteria: the state of preventing the appointment of adequate treatment, HIV-infection (group 1, n=30). The comparison group was consisted of patients receiving standard treatment in combination with inhaled administration of Isoniazid (group 2, n=21). Rezults. The clinical study has figured out: after a course of inhalations of Hixozide the clinical cure of bronchial tuberculosis occurs after the period of 2 months of treatment (according to the results of endoscopy of bronchi); more patients — 69.2% versus 38.1% in the comparison group, p=0,039 showed a positive trend during the nonspecific endobronchitis — 85,7% vs. 52,9%, p=0,017; the treatment and bacteriological conversion were achieved: 143±27 days in the first group vs. 164±32 days in the control group, p=0,019. Adverse reactions to Hixozide demanding its abolition occurred in 13,3%, they were stopped and did not affect the health of patients in the future. Conclusion. Inhaled Hixozide in the complex treatment of patients with tuberculosis accelerates clinical cure of tuberculosis of the bronchi, healing the lesions in the lung tissue and abacillation.

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Dynamics of the main epidemic indicators of tuberculosis in the Saratov region

Year: 2014, volume 10 Issue: №2 Pages: 289-293
Heading: Phthisiology Article type: Original article
Authors: Danilov A.N., Morozova T.l., Doktorova N.P.
Organization: Saratov State Medical University
Summary:

Objective; analysis of the dynamics of the main indicators of the ТВ epidemic in the Saratov region during the 5-year period. Material and Methods. The analysis of major indicators of epidemic (morbidity and mortality) in the Saratov region during the five years of observation. In the work a comparative evaluation of the parameters studied with analogical indicators in the Russian Federation was carried out. Results. During the period from 2009 to 2013 situation of tuberculosis epidemic in the Saratov region has positively stabilized. Over the past five years, the mortality rate in the region has decreased, while in the Russian Federation as a whole only on 25%, the incidence of the population in the region fell by 20%. It has been established that the later detection of a tuberculosis process leads to an increase in mortality and maintains reservoir of ТВ infection. Conclusion. In the Saratov region ТВ infection is thoroughly controlled. There is a well-established system for the detection, diagnosis, treatment and prevention of this specific process.

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