Saratov JOURNAL of Medical and Scientific Research

Parmacology

Pharmacoeconomic analysis of treatment of rheumatoid arthritis of the early stage and the most frequent comorbide conditions

Year: 2017, volume 13 Issue: №3 Pages: 462-468
Heading: Parmacology Article type: Original article
Authors: Okonenko T.l., Khrutsky А.К., Okonenko L.B., Egorova E.S.
Organization: Yaroslav-the-Wise Novgorod State University
Summary:

Objective: to define the regional structure of comorbid conditions of early rheumatoid arthritis (RA) and the cost of treatment. Material and Methods. Medical records of 100 patients with RA hospitalized in Velikiy Novgorod in 2010 and 2014 were analyzed. Range of drugs, used by doctors in the early stage of RA were considered, and and drugs were systematized. Pharmaceutical and economic analysis of medical records was conducted. Statistical data processing was executed using MS Excel. Results. A wide distribution of comorbid conditions in patients with early state of rheumatoid arthritis was established, the structure of concomitant pathology was determined. All the prescribed drugs and preparations with a frequency of more than 3% are allocated. The average cost for each drug use has been calculated, an ABC-analysis has been performed. Conclusion. Comparison of medical appointments and regulatory lists revealed that the standard is not fully observed. At an early stage of RA a high percentage of patients with comorbid conditions was noted (85.7-93.3%), predominantly cardiovascular, gastrointestinal, thyroid diseases. Cost of treatment of RA at an early stage and the most frequent comorbid status in 2014 has increased in comparison with 2010, the range of drugs in 2014 has decreased by 32%. The results of ABC-analysis of medicinal appointments revealed qualitative and quantitative changes in the major positions of the drugs.

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Analysis of the regional pharmaceutical market of hypoglycemic drugs of oral administration

Year: 2017, volume 13 Issue: №2 Pages: 225-228
Heading: Parmacology Article type: Original article
Authors: Orlova T.S., Buyuklinskaya O.V.
Organization: Northern State Medical University
Summary:

Aim: to study the regional pharmaceutical market of oral antidiabetic drugs for 2013-2016 according to the example of the pharmacy network of "Yuniver" (Arkhangelsk), not realizing the program of preferential home. Material and Methods. The study was conducted on the basis of reports on the movement of goods in "Yuniver OOO "for the period from 2013 to 2016 were analyzed range of oral antidiabetic drugs on international nonproprietary names, and trade names, dynamic oral antidiabetic drugs sales (number of dispensed packages). Results. On the basis of data on the movement of goods showed an annual expansion of assortment of oral antidiabetic drugs in the pharmacy network, not realizing the program of preferential home. Conclusion. The assortment of oral hypoglycemic preparations on the example of a pharmacy network that does not realize a program of preferential leave for people with diabetes mellitus testifies to the use of modern medicines that prevent the occurrence of microcirculatory disorders of target organs included in the list of vital and essential drugs and in accordance with clinical recommendations on therapy this pathology.

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Steroid compounds of phytogenic origin: scientometric research data of scientific and practical literature

Year: 2017, volume 13 Issue: №1 Pages: 014-021
Heading: Parmacology Article type: Review
Authors: Sukhanov А.Е., Buyuklinskaya O.V., Koptyaeva R.G.
Organization: Northern State Medical University
Summary:

Steroid compounds of phytogenic origin are important in clinical medicine rendering anti-inflammatory, anti-prolifer-ative and antithrombotic actions. However, steroid compounds of phytogenic origin, in particular, steroid saponins are insufficiently studied from an identification position in tissues of vegetable organisms and methods of their physical and chemical analysis. The scientometric analysis of research data (abstract documents) containing an analytical array of scientific publications concerning isolation, selection, cleaning, identification and the quantitative definition of steroid saponins in tissues of the higher vascular plants in the abstract bibliographic database SciVerse Scopus (Elsevier publishing house) with use of criteria "key word" and "the key phrase" is provided in the article.

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Magnetic resonance imaging and biomarkers of serum and urine wile diagnostics of kidney cancer

Year: 2016, volume 12 Issue: №1 Pages: 52-56
Heading: Parmacology Article type: Original article
Authors: Nickolsky Yu.Ye., Chekhonatskaya M.L., Zakharova N.B., Popyhova E.B., Ponukalin A.N.
Organization: Saratov State Medical University
Summary:

Purpose: improvement of differential diagnostics of benign and malignant renal tumors basing on complex estimation of the results of MRTand the level of such biomarkers as vascular endothelial growth factor, monocyte chemotactic protein-1 and matrix metalloproteinase-9 in blood serum and urine. Material and Methods. A total of 106 patients including the main group of 60 patients with renal cancer (RC), the group of comparison of 16 patients with benign renal tumors and the control group of 30 practically healthy persons were examined. ELISA was employed for detection of the biomarkers in blood serum and urine. The tumors were diagnosed by MRT Results. The increase of the level of the biomarkers in blood serum and urine was registered independently of the character of neoplastic process; more significant increase was observed in patients with RC, especially at the early stages of the disease. Some peculiarities of changing of the level of the biomarkers depending on the dimensions of malignant tumors were found. Conclusion. At the early stages of RC complex detection of the abovementioned biomarkers in blood serum and urine can serve an additional clinical diagnostic and prognostic criterion.

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Myeloprotective efficiency of combination of pyrimidine and 3-hydroxypyridine derivatives in experimental antineoplastic chemotherapy

Year: 2015, volume 11 Issue: №3 Pages: 258-262
Heading: Parmacology Article type: Original article
Authors: Siprov A.V., Masyagin V.A.
Organization: Mordovia State University n.a. N. P. Ogaryov
Summary:

The aim of the study is comparative assessment of the influence of separated and combined use of pyrimidine and 3-hydroxypyridine derivatives — xymedon and mexidol on the bone marrow hemopoiesis and peripheral blood quantitative indicators in rats with Walker-256 carcinoma at the doxorubicin and paclitaxel chemotherapy. Materials and Methods. Experiments have been carried out on 83 Wistar female rats of weight 150-250 grams. Doxorubicin in a dose of 4mg/kg and paclitaxel in a dose of 6mg/kg were administered intraperitoneally on the 11th day of experiment. Xymedon (100mg/kg) and mexidol (50mg/kg) were administered separately and in combination with each other, starting with the 11th day of experiment for 10 Says. We estimated myelograms and peripheral blood changes on the 14th and 22d day of the experiment. Results. Xymedon normalized differentiation of granulocytopoiesis cells more effectively than mexidol and reduced severity of erythrocytopenia on the 14th day of the experiment. Combination of xymedon and mexidol accelerated granulocytes differentiation more effectively than separated use of these medicines. It was accompanied by more effective increase of neutrophils number in peripheral blood. Despite the increase of poly-chromatophil normocytes number in bone marrow to the 22d day, the erythrocytes number in blood was not differed from one at separated use of these medicines. Conclusion. Myeloprotective effect of xymedon exceeds the effect of mexidol one. The combination of xymedon and mexidol accelerates granulocytes differentiation more effectively than separated use of these medicines.

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Regional anesthetic activity of new decahydroquinolinyl derivative by the experimental model of terminal anesthesia

Year: 2014, volume 10 Issue: №3 Pages: 384-389
Heading: Parmacology Article type: Original article
Authors: Goncharuk V.V., Buben A.L., Vdovichenko V.P.
Organization: Grodno State Medical University
Summary:

anesthesia. Material and Methods. Decahydroquinolinyl derivative under laboratory code PAS-68 synthesized in the A. B. Bekturov Institute of Chemical Sciences under the guidance of K. D. Praliev has been studied. Benzocaine, lido-caine and tetracaine were used as the comparison drugs. Male rabbits of 2,0-3,5 kg weight were used as experimental animals. A threshold of corneal sensitivity to tactile effects (Rainier index) was determined by the standard method. Computer prognosis of PAS-68 acute toxicity also was made. Results. The local anesthetic activity of 1 %, 0,5% and 0,25% solutions of PAS-68 were identified as higher than that for lidocaine and benzocaine in similar concentrations (p

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Cardioprotective efficiency study of combination of pyrimidine and 3-hydroxypyridine derivatives in experimental antitumor chemotherapy

Year: 2014, volume 10 Issue: №2 Pages: 257-261
Heading: Parmacology Article type: Original article
Authors: Siprov A.V., Kostina Yu.A.
Organization: Mordovia State University n.a. N. P. Ogaryov
Summary:

The aim of the study is to analyze the influence of combination of pyrimidine and 3-hydroxypyridine derivatives — xymedon and mexidol, in comparison with kardioxane on the myocardial bioelectric activity and arterial pressure level in rats with Walker-256 carcinoma at the doxorubicin and paclitaxel chemotherapy. Material and Methods. Experiments have been carried out on 100 Wistar female rats of weight of 150-250 grams. Doxorubicin and paclitaxel were administered intraperitoneally in a dosage of 4mg/kg and 6mg/kg respectively on the 11th day of experiment. Xymedon (100mg/kg) and mexidol (50mg/kg) were administered separately and in combination with each other, starting with the 11th day of experiment for 10 days. Kardioxane was injected in the dosage of 80mg/kg 20 min before cytostatics. We estimated a myocardial bioelectric activity and arterial pressure level changes on the 11th and 22d day of the experiment. The results. Xymedon and mexidol combination has limited the development of myocardial electrical instability comparable to kardioxane action. This combination has prevented the appearance of metabolic changes of ischemic genesis in the heart more efficiently than kardioxane. Xymedon and mexidol have normalized QT interval dispersion corrected by heart rate less efficiently than kardioxane. Conclusion. The combination of xymedon and mexidol has reduced cardiotoxicity of antitumor therapy more efficiently than the separated use of these medicines or the use of cardioxane.

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The assessment of bronchial asthma pharmacotherapy effectiveness on the background correction of magnesium deficiency in children

Year: 2014, volume 10 Issue: №1 Pages: 211-214
Heading: Parmacology Article type: Original article
Authors: Shishimorov I.N., Perminov А.А., Nefedov I.V.
Organization: Volgograd State Medical University
Summary:

Aim: to evaluate the efficacy of pharmacotherapy of bronchial asthma in children with concomitant correction of magnesium deficiency. Material and Methods. A 12-week, prospective, randomized, open, comparative, parallel-group, which was included in the 50 children with uncontrolled and partially controlled atopic asthma and laboratory-confirmed magnesium deficiency. For the groups 1 and 2 it was assigned basic therapy of asthma in accordance with the recommendations of GINA (2011). In the group 1 it had been additionally performed concomitant correction of magnesium deficiency of Magnesium B6 Forte. There had been evaluated the effectiveness of a drug therapy for 12 weeks on the achieved level of asthma control, the frequency of exacerbations, the number of asymptomatic days. Dynamics of the severity of allergic inflammation was assessed by monthly monitoring of levels of nitric oxide in exhaled air (FeNO). Results. After 12 weeks of treatment, the magnesium content in erythrocytes in group 1 (1.79 (1,68-1,89) mmol / L) increased by 15.7% and was statistically significant (p

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Organizational aspects of conducting of bioequivalence study

Year: 2014, volume 10 Issue: №1 Pages: 203-210
Heading: Parmacology Article type: Original article
Authors: Khokhlov A.L., Kagramanyan I.N., Lileeva E.G., Sinitsina O.A., Miroshnikov A.E., Shitov L.N.
Organization: Ministry of Health of the Russian Federation, Yaroslavl State Medical Academy
Summary:

Aim: to evaluate the organizational aspects of conducting bioequivalence study in Russia on the example of one of the clinical centers, Yaroslavl. Material and methods. On the basis of the Municipal Autonomous institution of health care of the Yaroslavl region Clinical hospital №2 (CH, clinical base of the Department of clinical pharmacology of YSMA) was held 93 bioequivalence studies and pharmacokinetics in the period from 2011 to 2014, of which 15 studies of foreign sponsors and 78 of domestic producers. Result.: The studies involved 48 volunteers of both sexes from the database of clinical center CH №2. There were 698 females (48.6%) and 739 males (51.4%). The average age of the volunteers was 26,37 years. In each study there were from 18 to 103 volunteers, depending on the design of the research Protocol. At the same time Russian studies ranged about 18-24 volunteers, about 30-103 volunteers abroad. The number of doubles in domestic studies ranged from 2 to 6 persons, and foreign — from 6 to 12 people. 10-15% from the whole number of subjects were not included into the study. Conclusion. In Russia bioequivalence of medicines for more than ten years is the main requirement of medico-biological control generic drugs. Regardless of the manufacturer to the generic drugs are exactly the same as the original drugs, must meet the following requirements: quality efficiency and safety. In connection with the increase in recent years of bioequivalence studies of medicines, require close monitoring of the quality of these studies on the territory of the Russian Federation.

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Pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancy

Year: 2014, volume 10 Issue: №1 Pages: 199-203
Heading: Parmacology Article type: Review
Authors: Reshetko O.V., Lutsevich К.А.
Organization: Saratov State Medical University
Summary:

Changes in maternal physiology and metabolic during pregnancy influence pharmacokinetics and illustrate that standard adult dosing is likely to be incorrect during pregnancy. Different pharmacometric approaches are available for design and analysis of clinical studies during pregnancy. Physiologically-based pharmacokinetic (PBPK) model could be used to evaluate different dosing regimens for pregnant women and serves in predicting drug exposure and response at the personal level.

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