Saratov JOURNAL of Medical and Scientific Research

Parkinson disease

Possible laboratory and instrumental markers of Parkinson's disease

Year: 2020, volume 16 Issue: №1 Pages: 336-341
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Kolmakova T.S., Oksenyuk O.S., Morgul E.V., Gelpey M.A., Vlasova N.D., Smirnova O.B., Mutalieva Kh.M.
Organization:
Summary:

Objective: to evaluate the role of a complex of markers of inflammatory processes and free radical oxidation, an immunoreactivity profile, stabilographic indicators in the pathogenesis of Parkinson's disease (PD) for possible use as clinically significant markers of early diagnosis of the disease. Material and Methods. 139 patients with PD, 31 patients as the control, and 11 patients as the comparison with Parkinson's syndrome were examined. The following parameters were evaluated in blood serum: antidodies to NF-200, GFAP, S100, MBP, voltage-dependent-Ca-chan-nel, Na-Choline, glutamate, dopamine, serotonin, Mu-Opiate, GABA receptors, (3-Endorphin; total antioxidant activity; malondialdehyde's accumulation; determination of small, medium, large and giant circulating immune complexes and medium-weight molecules. Postural functions were evaluated using a biofeedback computer stabilizer. Results. Significant differences in the profiles of immunoreactivity, neuroinflammation and endogenous intoxication in patients and in the control group were revealed. The stabilometric indicator of the quality of the equilibrium function significantly varied depending on the stage of PD. Conclusion. The results indicate a possible role of activation of the immune system and neuroinflammation in the process of neurodegeneration in PD. The autoimmune response is specific in nature, progressively changing depending on the stage of the disease.

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Clinical case of the manifestation of Parkinson's disease in a patient with neuro-leptic-induced parkinsonism

Year: 2019, volume 15 Issue: №1 Pages: 199-202
Heading: Neurology Article type: Case report
Authors: Yudina V.V., Makarov N.S., Yudina G.K.
Organization: Saratov State Medical University
Summary:

The article presents data on the mechanisms of development of drug-induced parkinsonism in patients taking neu-roleptic drugs, as well as on specifics of the development of Parkinson's disease in these patients. A clinical case of Parkinson's disease development in a patient with drug-induced parkinsonism who has been taken antipsychotics for a long time is described.

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Distinguishing features of the range of serum antibodies to nervous tissue antigens in Parkinson's disease

Year: 2019, volume 15 Issue: №1 Pages: 151-154
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Kolmakova T.S., Oksenjuk O.S., Morgul E.V., Gelpey M.A., Vlasova N.D., Kalmykova Yu.A.
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Summary:

The goal of this study was to perform a multivariable analysis of immunobiochemical parameters which reflect the state of nervous system microstructure in Parkinson's disease (PD). Materials and Methods. The study included 54 patients of the main group with a diagnosis of PD and 6 patients of the control group. The immunoreactivity profiles of natural regulatory auto-AB in serum were determined by ELISA using the ELI-P-Complex assay. The following parameters were assessed: ABto NF-200, GFAP, S100 proteins, MBP, beta-endorphin, voltage dependent Ca2+channel, H-cholinergic receptors, glutamate, dopamine, serotonin, opiate, GABA receptors. Results. The study revealed significant abnormalities in auto-AB profiles of the examined patients. Conclusion. The findings on the difference in range of auto- AB dependent on the duration of the disease and the revealed associations with the main characteristics of the disease can be used both for early diagnosis and for predicting the course of PD in the future.

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Investigation of the oxidative status in patients with Parkinson's disease

Year: 2018, volume 14 Issue: №1 Pages: 132-135
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Kolmakova T.S., Okseniuk O.S., Gelpey M.A., Isachkina N.S.
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Summary:

Currently, much attention is paid to the search for laboratory diagnostic tests for Parkinson's disease, which can be used to create a screening diagnostic panel. The aim of the research was to study markers of oxidative status in blood plasma and to correlate these indicators with the main clinical characteristics of Parkinson's disease. Material and Methods. The study included 32 patients of the main group and 21 patients as a control group. Blood was collected for the evaluation of total oxidative activity and general antioxidant status of the organism (OOAand OAA): determination of the activity of catalase, superoxide dismutase (SOD), malonic dialdehyde (MDA) in the blood serum by spectropho- tometric method. Results. The parameters of SOD, catalase, ОАА, OOA in patients with early stage of Parkinson's disease significantly differed from those of the control group Conclusion. Reduction of oxidative activity could slow down the development of the disease.

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Pain syndrome features in Parkinson's disease

Year: 2016, volume 12 Issue: №4 Pages: 706-712
Heading: Neurology Article type: Review
Authors: Bril Е.М., Udalov U.D., Anikina M.A., Zimnyakova O.S.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Pain in Parkinson disease take the special place among all of disease symptoms due to it pathogenetics and clinical diversity. In spite of the plurality of resent studies, the majority of clinical practioners and neurologists didn't pay attention to significant decline of the quality of life in patients with Parkinson disease and pain disorders. This article was created with aim to summarize all important results of studies, focused on pain pathogenesis and clinical features on different stages of disease.

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Influence of non-motor symptoms on the Parkinson's disease features and on quality of patients' life

Year: 2016, volume 12 Issue: №3 Pages: 362-366
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Gelpey M.A., Rabadanova E.A.
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Summary:

The main clinical symptoms of PD are well understood, but it is necessary to continue studying the changes of symptoms as it progresses. The aims of the research were: to study the structure of non-motor symptoms (NMS) at the early and last stages of PD, to determine the frequency and clinical significance of the NMS at different stages of PD, comparing the severity of NMS in PD with the severity of the same symptoms in the natural aging, to study the quality of life (QOL) of patients with the impact assessment of the NMS and the assessment of motor symptoms on this criterion. The material and methods. The study included 79 patients with PDand 25 patients without neurodegenerative disorders (control group). The degree of movement disorders severity was assessed using UPDRS scale. Cognitive function was assessed using the Montreal Cognitive Rating Scale (MoCA). To identify and assess the severity of NMS questionnaire used NMSS. Assessment of quality of life of patients was carried out by PDQ-39 questionnaire. Results. There was a significant difference between the intensity of the NMS in PD patients and the control group. Intensity of NMSs significantly correlated with disease stage, disease duration, with the points on the UPDRS scale. Conclusion. NMS significantly affect the quality of life, their severity and structure varies considerably from early to late stage PD, and they are the result of a neurodegenerative process, inherent in PD, and not the natural aging process.

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Identifying non-motor symptoms in Parkinson's disease and their connection with motor symptoms

Year: 2016, volume 12 Issue: №2 Pages: 281-285
Heading: Neurology Article type: Original article
Authors: Poverennova I.E., Kalinin V.A., Muchina S.A.
Organization: Samara State Medical University, Saratov State Medical University
Summary:

The aim: the identification of patterns of formation and course of non-motor fluctuations in this disease and theirs connection with motor symptoms. Materials and Method, for realization of a research objective at 54 patients with Parkinson's disease were used special diagnostic methods, for assess the credibility — methods of mathematical statistics. Results. It was established, that with increasing duration of disease degree of severity of non-motor symptoms grow up; it is noted a direct correlation between results in scales for exploration Parkinson's disease. Conclusion. In the treatment of patients with Parkinson's disease necessary consider the non-motor fluctuations. There are a lot of scales for exploration this disturbance, but they are subjective and for their conduction need a lot of time. So, question of creation new, objective and quick in carrying out scales are open.

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