Saratov JOURNAL of Medical and Scientific Research

ionizing radiation

Structure of condylar cartilage in white rats after 60-day sodium benzoate intake and exposure to ionizing radiation

Year: 2019, volume 15 Issue: №2 Pages: 358-362
Heading: Human anatomy Article type: Original article
Authors: Stepanenko I.G., Luzin V.I.
Organization: St. Luke Lugansk State Medical University

Aim of the study is to investigate the structure of condylar cartilage of mandible in rats after 60-day of sodium ben-zoate intake and ionizing radiation exposure both separately and simultaneously and fnd possibility of correction of the alterations found with sea-buckthorn oil. Material and Methods. The study involved 240 white rats distributed into 8 groups. Animals received intragastric sodium benzoate in dosage of 1500 mg / kg of body weight and were exposed to ionizing radiation (total 4 Gr. in 4 sessions). Sea-buckthorn oil was used as the correction drug (300 mg / kg of body weight). Morphometry of the condylar cartilage included zones morphometry and relations of volume components. Results. Application of sodium benzoate resulted in the narrowing of proliferation and subchondral osteogenic zones and the decrease of amount of primary spongiosa and osteoblasts; in readaptation period the structure of the cartilage was gradually restored. Ionizing radiation led to similar alterations while restoration period was longer. Action of both sodium benzoate and ionizing radiation resulted in severe alteration with no restoration observed. Application of sea-buckthorn oil resulted in faster restoration of cartilage structure. Conclusion. Combined action of sodium benzoate and ionizing radiation resulted in severe alterations of the mandibular condylar cartilage structure. Application of sea-buckthorn oil reduces negative efects of the experimental conditions on morphological functional features of the mandibular condy-lar cartilage.

2019_02_358-362.pdf460 KB

Multifocal atherosclerosis in patient after acute first degree radiation sickness.

Year: 2014, volume 10 Issue: №4 Pages: 862-867
Heading: radiation medicine Article type: Case report
Authors: Metlyaeva N.A., Lartsev M.A., Shcherbatykh O.V., Bushmanov A.Yu., Krasnyuk V.I.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency

Purpose: assessment the heavy psychosomatic and all-somatic cardiovascular and cerebrovascular pathology of patient, transferred an acute I degree radiation sickness, from the general evenly gamma-beta radiation. Conclusions. The subdepressive and disturbing-depressive syndrome of patient, transferred an acute radiation sickness (ARS) of I degree, from the general evenly gamma-beta radiation, was independent risk factor of development of multifocal atherosclerosis; Features of development of all-somatic and psychosomatic pathology of patient are based on a combination of genetic prerequisites, environment influences (the stress caused by accident on the ChNPP) and social factors, influencing on him during a course of life, especially during early socialization. Thus at development of psychosomatic frustration the combination of feature of the mental reaction connected with the personal characteristic and special relationship between mental (stress) and physiological (somatic) by aspects of reaction which led to metabolism violation, to aging, decrease in adaptation opportunities of an organism and development age — dependent pathology took place.

2014_04-01_862-867.pdf298.77 KB

Psychophysiological adaptation of the patient with the remote effect of the III degree acute radiation syndrome

Year: 2013, volume 9 Issue: №4 Pages: 897-901
Heading: radiation medicine Article type: Original article
Authors: Metlyaeva N.A., Lartsev М.А., Shcherbatykh О.V., Bushmanov A.Yu.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency

Aim: clinical psychophysiological assessment of social and psychophysiological adaptation of the patient with the remote effect of the III degree acute radiation syndrome, with local radiation injuries of heavy degree from the extremely uneven gamma and neutron radiation with the subsequent amputation of both feet at level in top / 3 shins, according to feature of its individual mental adaptation and the periods of its mental adaptation stages. Material and methods. The object of the research was a patient (born in 1939) who worked as an engineer in the National Research Centre (NRC "Kurchatov Institute") from 1963 to 2010, the senior researcher. Psychophysiological inspection of the patient had been organized according to the MMPI test, Kettell's test, Raven in 30 years after radiation accident (1971) in dynamics in 2001, 2002, 2006, 2009 with the use of the automated program and methodical Expert complex intended for research of the properties, cognitive and intellectual features of the personality. Results. Average profile of multilateral research of the personality (MMPI) and the dynamics of indicators according to the years of supervision (2001-2009) points to a disharmonious combination of hypochondriac, disturbing and depressive and demonstrative tendencies to prevalence of a demonstration, as firmness manifestation before a heavy illness at the patient after the III degree acute radiation sickness, and local radiation injuries of heavy degree from the extremely uneven gamma and neutron radiation, am-
putation of both shins at level in top / 3, late beam buttock, right hip ulcers, a beam cataract of the III degree of both eyes, stabilized. The assessment of the efficiency of psychophysiological adaptation in dynamics with 2009 indicates emergence of prevalence of hypochondriac tendencies over a demonstration with accession of high uneasiness and autistic lines at preservation of the leading role of an hypochondriac somatization of alarm with considerable decrease in an emotionality, an integration, a freedom of behavior. The changes revealed in dynamics correspond to the specific increase weight of violations of mental adaptation, characteristic for the period of adaptation exhaustion. The high intelligence, good figurative and logical thinking, well-mannered forms of behavior, high control over the emotional sphere, restraint of emotions, independence, self-sufficiency, organization, behavior taking into account environment requirements provided the patient M. firmness before a heavy illness, promoted good adaptation to an environment with confidence in myself, high social adaptability, opportunity successfully to carry out duties, hold the work account (worked 39 years after accident). Comparative assessment of operator ability of the patient M. showed good average time of common and difficult sensorimotor reactions with 2 mistakes, high time of reaction for moving object, however decrease in accuracy of reaction from 10-13% to 2% testifies to manifestation in dynamics of insufficiency of real functional reserves of nervous system. Conclusions. Efficiency of psychophysiological adaptation depends not only on a dose of radiation and weight of the transferred disease, but, mostly, on premorbid properties of the identity of the victim and his social and labor installation.

2013_04-01_897-901.pdf611.99 KB