Saratov JOURNAL of Medical and Scientific Research

hemostasis

Characteristics of platelet aggregative ability at patients with brain infarction and marked stenosis of cerebral arteries

Year: 2012, volume 8 Issue: №3 Pages: 770-774
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Stepanova Yu.l., Gontchar I.A., Likchachev S.A.
Organization:
Summary:

The central part of brain infarction (Bl) pathogenesis is hemostatic blood activation. Aim: to study platelet aggregative ability in dynamics of acute Bl at the marked stenosis of cerebral arteries (>50%). Materials and methods. Investigation included 39 patients at acute Bl with average age 73,9±8,3 years. Control group consisted of 18 healthy persons with average age 60,2±6,8 years. Evaluation of platelet aggregation was performed with application of light-transmission aggregometer «SOLAR» (RB) and aggregation inductors — solutions of adenosine diphosphate with concentration of 0,5 и 2,0 umol/l and collagen of 2,0mg/ml concentration. Results. Significant hyperaggregation platelet reaction on the 1 st and 10th days of hospitalization without positive changes under treatment has been revealed. Conclusion. Thus, obtained results prove the necessity of monitoring of individual patients sensitivity to antiplatelet therapy in secondary prevention of ischemic stroke with optical aggregometry and inductors complex.

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Peculiarities of homeostatic system in highland conditions using llizarov distraction transosseous osteosynthesis method

Summary:

Purpose. The purpose is to study the reaction of homeostasis system in stable and in distraction llizarov transosseous ostesysnthesis of the limbs bones at experimental animals (dogs) in highland conditions. Material and Methods. 63 adult mongrels aged from 1 to 3 years with 10-20 kg body weight and 15 cm minimal length of tibia were included in the experiment. Open osteosotmy of tibial mid-shaft followed by Kirschner wires insertion through tibial bone and llizarov frame assembly comprising 3 or 4 rings was performed under IV anaesthesia at 3200 m altitude above sea level. In experimental group including 33 mongrels the distraction was performed on the 5th day after osteotomy by 1 mm rate divided into 4 times within 10 days but in control group comprising 30 dogs the distraction was not provided. Every 10 days after distraction blood samples were taken in both groups to examine coagulation; the samples were taken from subcutaneous lateral tibial vein, ex tempora mixing with 3,8% solution of sodium citrate at 9:1 ratio. Then the plasma was separated and examined biochemically according to the accepted standards. Results. We obtained the data witnessing activation of coagulation component of homeostatic system in stable osteosynthesis of the limb bones using llizarov fixator with simultaneous inhibition of fibrinolytic component. In distraction osteosynthesis hyper-coagulation trend in homeostasis system with simultaneous suppression of fibrinolytic blood activity is vividly defined within the entire experiment period. Conclusion. Transosseous distraction osteosynthesis in highland condition causes considerable shifts in the system of homeostasis with definite domination of coagulation component which promotes formation of pre-thrombotic condition. Limb segment lengthening on the background of pre-thrombotic condition increases the risk of thromboembolic complications in highland conditions and requires appropriate measures of prophylaxis

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Scientific and practical contribution of professor S.A. Georgieva to development of Russian physiology (dedicated to the 100-th Anniversary)

Year: 2011, volume 7 Issue: №4 Pages: 981-983
Heading: History of Medicine. Anniversary Dates Article type:
Authors: Kirichuk V.F., Zavyalov A.I., Tokaeva L.K., Babichenko N.E., Slezkina S.B.
Organization: Saratov State Medical University
Summary:

The article presents the most significant facts from biography of professor S.A. Georgieva. S.A. Georgieva made a great contribution by her scientific, pedagogical and public work to the development of Saratov medical institute. Her research work was directed to the study of hemostasis

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Dependence of hemostasis indices on external environment nemperature in women with physiological pregnancy accompanied by limitation of liquid intake

Year: 2011, volume 7 Issue: №4 Pages: 801-804
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Arkhipov I.V., Marshalov D.V., Markov A.L., Gurianova N.S., Zhulina N.V.
Organization: Saratov State Medical University, Municipal Center of Clinical Hemostasiology and Transfusiology Chief laboratory, Saratov Emergency Aid Station
Summary:

The research goal was to study the influence of extremely high temperatures on the hemostasis indices in patients with uncomplicated pregnancies with the concomitant limitation of liquid intake. The research results of hemostasis of pregnant women being hospitalized during the period of spring and summer in 2010 have been analyzed. The differences in the level of hypercoagulation changes of hemostasis in summer and spring have been found to be insignificant. In the platelet link hemostasis in summer of 2010, as compared to the spring, the increase of platelet aggregation and amount has been observed, with the exception of the third trimester, which is marked by the decrease of platelet amount. Hot seasons and liquid intake limitations make additional demands on hemostasis adaptive capacity, increasing the risk of thrombohemorrhagic complications

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Lowinvasive technologies and hemostasis system at a hysteromyoma

Year: 2011, volume 7 Issue: №3 Pages: 587-592
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Rogozhina I.E., Khvorostukhina N.F.
Organization: Saratov State Medical University
Summary:

Research objective. Study of condition of hemostasis system at patients with hysteromyoma complicated by bleeding; comparative estimation of hemostasis indicators at patients with uterine arteries embolization (the basic group n=48) and abdominal hysterectomy (comparison group n=65). Materials and methods. Complex study of the basic hemogram parameters and hemostasis at 162 patients with hysteromyoma and 30 patients without marked genital pathology (the II control group) was carried out. 48 patients formed the main group which was subjected to uterine arteries embolization for bleeding break; 65 patients (the comparative group) were surgically operated upon abdominal hysterectomy; 49 patients with hysteromyoma had no bleedings and formed the control group. Research of hemostasis system was carried out by means of test-tube method, and also by plotting set for express-diagnostics, analysis of thrombocyte unit of hemostasis system was realized with 2-channel analyzer of thrombocyte aggregation «Biola» — LA 230. Results. Presented analysis of hemostasiogram parameters allows to state development of chronic DIC-syndrome in women with hysteromyoma. Reliable shortening of coagulation index, decrease of thrombocyte aggregation function in comparison to the control group data were revealed. Conclusion. Development of hyper coagulation with increase of paracoagulative products with simultaneous activation of fibrinolysis processes in all the patients with hysteromyoma was revealed. Minimal effect of embolization of uterine arteries to hemostasis system in patients with hysteromyoma was marked. And they were intensified after surgical treatment, which is the evidence of definite advantages of this method unlike of hysterectomy

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Modern review of pathogenesis of urgent uterine bleedings in obstetrical and gynecological practice

Year: 2011, volume 7 Issue: №1 Pages: 059-065
Heading: Obstetrics and Gynecology Article type: Review
Authors: Rogozhina I.E.
Organization: Saratov State Medical University
Summary:

The article presents modern data concerning mechanisms of uterine bleedings in undeveloped pregnancy, hystero-myoma, and cervical carcinoma. Hemostasis system malfunctions appeared in case of dead foetus in uterus have been considered in the work. They are manifested by consumption coagulopathy and haemorrhagic complications. Uterine bleedings in case of hysteromyoma are caused by dilation of arterial vessels and deprivation of their contractile function and malfunction myometrium contraction. Complications that occur in oncological uterine bleedings arrest have been described. They are caused by individual uterine blood supply and developed network of collateral anastomoses between branches of internal iliac arteries

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ДВС-СИНДРОМ ПРИ ХРОНИЧЕСКОЙ ПОЧЕЧНОЙ НЕДОСТАТОЧНОСТИ (RUS)

Year: 2006, volume 2 Issue: №4 Pages: 19-23
Heading: Urology Article type: Original article
Authors: Maslyakova G.N., E.N. Cmokaluk
Organization: Saratov State Medical University
Summary:

Based on the analysis of 28 autopsy cases the incidence and morphologic manifestations of disseminated intravascular blood coagulation in patients with the chronic renal insufficiency were studied.

Keywords: hemostasis

INFLUENCE OF SEASON PATTERN ON PREVALENCE AND SEVERITY OF ACUTE MYOCARDIAL INFARCTION, FUNCTION OF HEMOSTASIS IN PATIENTS WITH ISCHEMIC HEART DESEASE OF CLIMATE AREA OF MIDDLE VOLGA REGION

Year: 2007, volume 3 Issue: №3 Pages: 68-72
Heading: Internal Diseases Article type: Original article
Authors: O.K. Rybak, A.N. Burlaka, N.P. Ivannikova, A.P. Burlaka
Organization: Saratov Institute of Cardiology, Russia, Saratov State Medical University
Summary:

The aim of this study is to evaluate season pattern, severity and outcome of acute myocardial infarction in dependence of yearly patterns of function of hemostasis in middle Volga Region. Season pattern of prevalence myocardial infarction with winter peak was discovered, be accompanied of increase platelet aggregation, deterioration of blood viscosity, fibrinolysis depression. Most serious clinical course of summer myocardial infarction was observed with prosperity of hemostasis.

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THE MEANING OF NITRIC OXIDE IN REGULATION OF MICROCIRCULATORY UNIT OF HAEMOSTASIS: AN OVERVIEW

Year: 2007, volume 3 Issue: №3 Pages: 39-44
Heading: Physiology and Pathophysiology Article type: Review
Authors: E.V. Andronov, V.F. Kirichuk, A.N. Ivanov, N.V. Mamontova
Organization: Saratov State Medical University
Summary:

In this overview given the information about a role of nitric oxide in the regulation of microcirculatory unit of haemostasis. Discussed the questions about the meaning of nitric oxide in regulation of aggregation activity of platelets and functional properties of red blood cells.

Keywords: hemostasis
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RHEOLOGICAL PROPERTIES OF BLOOD AND DISTURBANCES IN PATIENTS WITH ISCHEMIC HEART DISEASES

Year: 2007, volume 3 Issue: №1 Pages: 16-24
Heading: Physiology and Pathophysiology Article type: Review
Authors: Mamontova N.V., Kirichuk V.F.
Organization: Saratov State Medical University
Summary:

The large number theoretical and practical recommendations confirming participation Theological disturbances in many diseases, including cardiovascular system, have described by present time. Rheological disturbances of blood viscosity, plasma and serum, aggregation and deformability of erythrocytes are observed at patients with ischemic heart diseases, in particular, the unstable angina. Interest to preventive measures and treatment of cardiovascular diseases is determined by wide expansion of ischemic heart diseases, its leading part in the reasons of invalidity and death rate of the population so this problem is not only medical, but also social one.