Saratov JOURNAL of Medical and Scientific Research

Macro- and Micromorphology

ROLE OF TUMOR SUPRESSOR P53 IN GENESIS OF ANGIOGENIC PHENOTYPE OF A NEOPLASM IN COURSE OF OVARIAN CARCINOMA

Year: 2008, volume 4 Issue: №1 Pages: 29-33
Heading: Macro- and Micromorphology Article type: Original article
Authors: I.I. Antoneeva, S.B. Petrov
Organization: Kazan State Medical University, Ulyanovsk State University
Summary:

The parameters of a vascular bed (vascular volume in % andvasculardencityon 1 mm2 of tumor) were estimated on the operational-bioptic aspirate of the primary tumor of 83 patients with the ovary cancer (ОС). The immunohistochemical method with the use of mice monoclonal antibodies p53, clone DO-7, lgG2b(M7001 DakoCytomation) has been applied for the estimation of the level of p53 expression. Based on the estimated parameters we can conclude that there is no distinctive group of differences among the different clinical stages of the ОС. However, there is a weak positive correlation between the volume and density of vessels and the disease stages. At the same time, the quantity of the atypical epithelial cells of the primary tumor that express p53 is significantly increasing in each subsequent stage. The results of the research show the possible p53 inactivation in the tumor cells and the stimulatory role ofp53in the neoangiogenesis in the course of the tumor progression.

AttachmentSize
2008_01_029_033.pdf306.7 KB

STRUCTURAL FEATURES OF RABBIT SHIN-BONE AFTER FLUOROSIS EXPERIMENTAL MODEL CREATION

Year: 2009, volume 5 Issue: №1 Pages: 17-20
Heading: Macro- and Micromorphology Article type: Original article
Authors: Yu.A. Barabash, A.A. Barabash, V.N. Karmazov
Organization: Saratov Scientific Research Institute of Traumatology and Orthopedics
Summary:

Impact of ecological factors and chronic intoxications on an organism is not accounted in treatment of bone injuries. The more significant osseous tissue modifications arise in case of fluoric intoxication accompanied by structural bone modifications. The main structural changes of more and less variability by mineral density of similar shin-bone zones of rabbit at fluorosis have been revealed in the research.

AttachmentSize
200901_017_020.pdf1.21 MB

HISTOFUNCTION TRANSFORMATION IN ENDOCRINE AND IMMUNE ORGANS UNDER VARIOUS REGIMEN INFLUENCE OF ELECTROMAGNETIC RADIATION

Year: 2009, volume 5 Issue: №1 Pages: 36-40
Heading: Macro- and Micromorphology Article type: Original article
Authors: E.B. Rodzaevskaya, J.V. Polina, I.A. Uvarova, V.D. Tupikin, L.I. Naumova, N.V. Bogomolova, M.O. Kurtukova, O.V. ZIobina
Organization: Saratov State Medical University, Astrakhan State Medical University
Summary:

The effects of resonance and no-resonance of the low-intensify EMW frequency regimes were examined in Vistar rats,males. The microscopic structures and histochemical changes in thyroid, thymus,adrenals,ovaries,and other organs were studied. Our researchers evidenced, that the resonance EMW frequency regime slightly stimulates cell mitotic activity and exchange of substances in organ’s parenchyma and micro-circulation in connective tissue stroma. Treatment the course of no-resonance frequency EMW regime deteriorates the ratio between parenchyma and mesenchyme components correlation is detected in organ.

AttachmentSize
200901_036_040.pdf434.88 KB

MORPHOFUNCTIONAL INDICES AND RISK FACTORS OF CARDIOVASCULAR HEART DISEASES AT STUDENTS’ HEALTH EVALUATION

Year: 2009, volume 5 Issue: №1 Pages: 31-36
Heading: Macro- and Micromorphology Article type: Original article
Authors: A.V. Lobacheva, V.N. Nikolenko, A.A. Svistunov, S.L. Bieber
Organization: University of Wyoming, USA, Saratov State Medical University
Summary:

This article contains the results of examination of morphofunctional parameters; determination of somatotypes; identification of cardiovascular diseases’ risk factors, and evaluation of health condition of students -all of which can be used for the development of personalized health preservation programs.

AttachmentSize
200901_031_036.pdf278.87 KB

ACTIVITY OF CANONICAL WNT SIGNAL SYSTEM IN HYALINE CARTILAGE ARTICULAR CHONDROCYTES IN PROCESS OF SYNOVIAL JOINT DEVELOPMENT

Year: 2009, volume 5 Issue: №1 Pages: 26-31
Heading: Macro- and Micromorphology Article type: Original article
Authors: S.L. Kuznetsov, A.O. Molotkov
Organization: First Moscow State Medical University n.a. I.M. Sechenov
Summary:

Canonical and non-canonical Wnt systems are essential regulators of chondrogenesis and bone development. However, the roles of these systems in synovial joint development are not well studied. To determine if canonical Wnt system is active in developing articular chondrocytes we used immunohistochemistry for в-galactosidase and doublecortin (cell-type specific marker for articular chondrocytes) to double label sections through joint regions of E14.5, E18.5, P10 and adult mice. Here the following results are presented. Canonical Wnt signal system does not
work in developing articular chondrocytes at early embryonic stages (E14.5); it is active in the articular chondrocytes at late embryonic stages (E16.5-E18.5) and during postnatal development (P7-P10), but is turned off again in the adult articular chondrocytes. These results suggest that canonical Wnt signaling is being regulated during articular chondrocytes differentiation and joint formation.

AttachmentSize
200901_026_031.pdf283.98 KB

SUMMARY SECTION CHANGES OF SUBEPICARDIAL ARTERIAL CHANNEL IN PEOPLE OF OLD AGE

Year: 2009, volume 5 Issue: №1 Pages: 24-26
Heading: Macro- and Micromorphology Article type: Original article
Authors: A.A. Korobkeev, O.A. Buzarova
Organization: Stavropol State Medical University
Summary:

The dynamics of summary section changes of different levels of coronary arteries branching in people of old age within different variations of the coronary arteries bifurcation has been under the study.
The research results in the determination of the summary section changes of coronary vessels and their connection with both topography, and the variations of their branching.

AttachmentSize
200901_024_026.pdf216.4 KB

COMPARATIVE CHARACTERISTICS OF MORPHOMETRIC PARAMETERS OF DIFFERENT FORMS OF GIRLS FEET AGED 17-19

Year: 2009, volume 5 Issue: №1 Pages: 20-23
Heading: Macro- and Micromorphology Article type: Original article
Authors: V.N. Nikolenko, O.V. Konnova
Organization: Saratov State Medical University
Summary:

During examination of plantograms of the girls (n = 242) three forms of feet: egiptal, rectangular and greek have been distinguished, statistically characterized by reliable distinctions of separate linear and angular parameters and coefficient of the anterior part of the foot. Coefficients used for examination of the pathology of the foot fornix do not possess sufficient information and need additional examination of the dimensions of the angels of ankle-bone, calcaneal and navicular bones.

AttachmentSize
200901_020_023.pdf487.16 KB

VOLUME VARIATIONS OF ARTERIAL AND VENOUS VESSELS OF CORTICAL AND MEDULLARY KIDNEY SUBSTANCES IN THE PROCESS OF AGEING

Year: 2009, volume 5 Issue: №1 Pages: 15-16
Heading: Macro- and Micromorphology Article type: Original article
Authors: Asfandiyarov F.R., Kafarov E.S., Trizno M.N.
Organization: Astrakhan State Medical University
Summary:

Research objective is the study of volume variations of arterial and venous vessels of cortical and medullary kidney substances of male and female sexes. Morphological changes in kidneys in the process of ageing have been revealed and have been characterized as a progressive nephrosclerosis.

Keywords: volume, vein, kidney, artery, ageing
AttachmentSize
200901_015_016.pdf198.27 KB