Saratov JOURNAL of Medical and Scientific Research

phototherapy

Vitiligo: modern methods of therapy

Year: 2017, volume 13 Issue: №3 Pages: 668-673
Heading: Dermatovenerology Article type: Review
Authors: Talnikova Е.Е., Svenskaya Yu.l., Dobdina A.Ju., Fatakhova Kh.V., Utz S.R.
Organization: Saratov State Medical University, Saratov state university
Summary:

This brief review focuses on the main issues of vitiligo treatment. The article provides insight into modern methods of dermatosis therapy discussing their potential, efficiency, safety, as well as represents a variety of standard treatment regimens.

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Study results of DNA damage dynamics in mononuclear cells in patients with psoriasis under phototherapy impact

Year: 2017, volume 13 Issue: №3 Pages: 622-628
Heading: Dermatovenerology Article type: Original article
Authors: Okhlopkov V.A., Gudinova Zh.V., Poleschuk E.l., Zhernakova G.N., Repina T.V.
Organization: Omsk State Medical Academy
Summary:

Objective: to investigate the effect of phototherapy on the level of DNA damage in mononuclear blood cells in patients with psoriasis using DNA Comet Assay. Material and Methods. 87 patients with psoriasis were included into the group treated by photochemotherapy; and 58 patients composed the group receiving 311 nm narrow-band phototherapy. Results. The median mean values for the median of DNA damage in the mononuclear cells under phototherapy exposure do not exceed the standard reference range. While performing a visual study of the dynamics of DNA damage level in the nucleated cells, the patients with the parameters exceeded the initial values and upper level of the reference range have been identified. UV-induced increase of DNA damage level in the mononuclear blood cells may indicate the slowing down the activity of DNA repair system processes. A predictive model for DNA damage final level from the initial values under phototherapy has been obtained, allowing identifying the patients with increased sensitivity to ultraviolet irradiation and slowing down the processes of DNA excision nucleotide repair. Conclusion. Biomonitoring of DNA damage level in the nucleated blood cells under photochemotherapy exposure and UVB-311nm demonstrates the efficacy of nucleotide excision repair processes in the studied groups of patients with psoriasis and the safety of phototherapy in compliance with medical technology.

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About the clinical effectiveness of the far long-wave UV-therapy

Year: 2015, volume 11 Issue: №3 Pages: 431-434
Heading: Dermatovenerology Article type: Short message
Authors: Alipov N.V.
Organization: Saratov State Medical University
Summary:

Objective: to assess clinical efficiency and safety of using long wavelength ultraviolet therapy in children children and adolescents suffering from atopic dermatitis during exacerbation of the dermatosis. Materials and methods. The data about the usage of the far long-wave UV therapy in the treatment of 38 children suffering from atopic dermatitis. The 2nd group of patients (42 patients) received standard therapy with the use of the usual doses and methods of taking medication and did not differ from the first group by age of patients, duration and form of the disease. Results. All observed on the background of therapy was noted positive dynamics of the pathological process in the skin, however, patients of the 1st group were observed earlier (average 5-7 days) than in the 2nd group, resolution of the clinical manifestations of AD, which was confirmed by a significant decrease in SCORAD values (1,9±0,7; p

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Phototherapy in atopic dermatitis: modern possibility of using

Year: 2014, volume 10 Issue: №3 Pages: 518-521
Heading: Skin Diseases Article type: Review
Authors: Alipov N.V.
Organization: Saratov State Medical University
Summary:

This review summarizes current aspects of pathogenetic treatment of atopic dermatitis. Using this data may predict the course of the disease, to carry out timely diagnosis, to determine adequate pathogenetically based treatment, to prevent the development of complications. The results of the application of the standard methods of treatment and the different option.

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2014_03-01_518-521.pdf249.02 KB

Blue and red light acne in acne therapy

Year: 2013, volume 9 Issue: №3 Pages: 577-582
Heading: Dermatovenerology Article type: Review
Authors: Utz S.R., Galkina Е.М., Raigorodskiy Y.M.
Organization: LLC «TRIMA», Saratov State Medical University
Summary:

The review presents the results of the research of acne phototherapy. The foundational photobiological principles of acne therapy are considered, biomedical and therapeutic values of different wave lengths are discussed, a clinical case of laser technologies use is presented.

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