Effectiveness evaluation of application of niosomal gel "Regenerin" in the treatment of chemical burns of cornea
Year: 2017, volume 13 Issue: №2 Pages: 216-220
Heading: Microbiology Article type: Original article
Authors: Bazikov I.A., Botasheva V.S., Kalinkina N.I., Maltsev A.N., Kostyukova N.Yu., Domenyuk D. A.
Organization: Stavropol State Medical University
Heading: Microbiology Article type: Original article
Authors: Bazikov I.A., Botasheva V.S., Kalinkina N.I., Maltsev A.N., Kostyukova N.Yu., Domenyuk D. A.
Organization: Stavropol State Medical University
Summary:
The aim of the work was to study the effectiveness of using the ophthalmic gel "Regenerin" in the treatment of a simulated chemical burn of the cornea in an experiment. Material and Methods. The chemical composition of the drug "Regenerin" was studied by mass spectrometry The regenerative action of the niosomal gel, including low molecular weight peptides extracted from placental cells and encapsulated, was then studied in 40 organisms of 20 rabbits of the chinchilla breed with a 10% solution of caustic soda. The subjects of the study are divided equally into two groups: in the experimental group, the treatment was carried out by applying a gel to the burn surface, the therapy was not performed in the control group. Results. The result of treatment with the "Regenerin" Ophthalmic Gel is a significant reduction in the timing of reparative regeneration in the animals of the experimental group due to increased metabolism and corneal neovascularization processes. Conclusion. The combined effect of these mechanisms, manifested in the arrest of edema, resorption of inflammatory infiltrates, normalization of the integrity of the endothelium, epithelial layer and basal membrane leads to completely restoring the histological structure of the cornea on the seventh day.
Bibliography:
1. Chalanova Rl, Degtyarenko TV. Practical significance of the clinical and immunological assessment of the stress-reactivity of the organism for ophthalmocabustiology (third report). Journal of Ophthalmology 2010; (6): 31-37
2. Kanyukov VN, Stadnikov АА, Trubina ОМ, Yakhina ОМ. State of rehabilitation problem of patients with corneal pathology (review). Vestnik of OSU 2012; (1): 192-194
3. Bazikov IA, Lukinova VV, Malinina Nl, Maltsev AN. Pathomorphological changes of the cornea using ophthalmologic niosomal gel "Regenerin" in the experiment. Eurasian union of scientists 2016; 24 (3): 40-42
4. Bazikov IA, Malinina Nl, Maltsev AN. The effectiveness of ophthalmic niosomal gel «Regеnerin» in the experiment. Problems in medical mycology 2016; 18 (2): 41
5. Instructions on military field surgery. In: Damage to the organ of vision. M., 2013; p. 195-218
6. Popov VA. Wound process: nanobiotechnology optimization. St. Petersburg: Speclit, 2013; 199 p.
7. Yoshinori О, Nishida К. Regeneration medicine for the cornea. BioMed Res Int 2013: 428247
8. Zeppieri M, Salvetat ML. Human adiposederived stem cells for the treatment of chemically burned rat cornea: preliminary results. Curr Eye Res 2013; (4): 451-463
9. Rama P, Matuska S, Paganoni G, et al. Limbal stem-cell therapy and long-term corneal regeneration. J Med 2010; 363 (2): 147-155
10. Selivanov DV, Rudko AS, Zlobin IA, Chernysh VF, Maltsev DS. Influences of the amniotic membrane extract on the development of neovascularization of the cornea after alkaline burns. In: Materials of the IX All-Russian Scientific Conference of Young Scientists with International Participation. Moscow, 2015; vol. 3, p. 147
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