Saratov JOURNAL of Medical and Scientific Research

Improvement of surgical treatment efficiency for malignant eyelid tumors of epithelial origin using autofluorescence imaging

Year: 2020, volume 16 Issue: №2 Pages: 587-591
Heading: Ophtalmology Article type: Original article
Authors: Bochkareva A.N., Egorov V.V., Smoliakova G.P., Banshchikov P.A.
Organization: Postgraduate Institute for Public Health Workers, S. Fyodorov Eye Microsurgery Federal State Institution

The purpose of the study is to evaluate the possibility of autofluorescence diagnostics (AFD)to determine the tumor boundaries and volume of surgery in patients with eyelid tumors of epithelial origin. Material and Methods. The study consisted of 3 parts: analysis of incidence of of eyelid basal cell carcinoma (BCC) recurrence; analysis of medical records of patients who underwent AFD at the primary visit for differential diagnostics between malignant and benign tumors; assessment of accuracy of determining tumor boundaries using visual diagnostics and AFD, based on the study of morphological sections of tumor fragments obtained after eyelid resection. Results. With 1.5 year follow-up period after surgical removal of BCC with visual diagnostics of its borders, the recurrence of the disease was verified in 18% patients. The use of AFD for differential diagnostics between malignant and benign tumors of eyelids skin and periorbital area showed that the method is effective for initial diagnosis of epithelial tumors in the outpatient unit. The AFD of the BCC boundaries compared with visual diagnostics is more accurate, it does not require long time and does not cause complications. Conclusion. The AFD can be used in ophthalmic oncology for early examination of the eyelid skin and periorbital area, it determines the boundaries of common pathological process more accurately, which guarantees complete removal of tumor and reduces the risk of its recurrence.

1. Likhvantseva VG, Novikov IA, Osipova EA. Study of spectral component of autofluorescence of skin and mucous membranes is normal and pathological. In: Domestic antitumor drugs: Abstract book of the All-Russian scientific and practical conference, 2007. Moscow, 2007.
2. Hanmurzaeva AG. Spectroscopic methods in diagnosis of malignant skin tumors: PhD abstract. Moscow, 2012; 24 p.
3. Brovkina AF. Ophthalmic oncology: guidelines for doctors. Moscow: Meditsina, 2002; 424 p.
4. Bower СР, Lear JT, de Berker DA. Basal cell carcinoma follow-up practices by dermatologists: a national survey. Br J Dermatol 2001; 145 (6): 949-56. DOI: 10.1046/j. 1365-2133.2001.04488.x.
5. Banshchikov PA, Luzianina VV, Smoliakova GP Possibilities prevention of relapse of malignant epithelial neoplasms of eyelids. In: Evidence-based medicine is the basis of modern healthcare: Abstract book of the VIII International Congress. Khabarovsk, 2010; p. 45-8.
6. Volgin VN, Sokolova TV, Kolbina MS. Basal cell carcinoma of skin: diagnosis, treatment. Vestnik dermatologii i venerologii 2013; (2): 16-23.
7. Grusha YaO, Ismailova DS. Surgical treatment of malignant neoplasms of epithelial origin. Head and Neck Tumors 2012; (2): 24-8.
8. Likhvantseva VG, Anurova ОА. Tumors of the eyelids: clinic, diagnosis, treatment. Moscow: GEOTAR-Media, 2007; 447 p.
9. Piskalkova ТР. Comparative characteristics of some methods of treatment of basal cell carcinoma of skin. Almanac of Clinical Medicine 2006; (9): 105-9.
10. Safronenkova IA. Treatment of patients with malignant epithelial tumors of the eyelid skin with lesion of the anterior part of the orbit. Ophthalmology Journal (Ukraine) 2013; (5): 46-50.
11. Hamada S, Kersey Т, Thaller VT. Eyelid basal cell carcinoma: non-Mohs excision, repair and outcome. Br J Ophtalmol 2005; 89 (8): 992-4. DOI: 10.1136/bjo. 2004.058834
12. Novikov IA, Grusha laO, Kiriushchenkova NP Autofluorescent diagnostics of skin and mucosal tumors. The Russian Annals of Ophthalmology 2013; 129 (5): 147-54.
13. Betz CS, Mehlmann М, Rick К, et al. Autofluorescence imaging and spectroscopy of normal and malignant in patient with head and neck cancer. Laser Surg Med 1999; 25 (4): 323-34. DOI: 10.1002/(sici) 1096-9101 (1999) 25:4<323::aid-lsm7>3.0. co;2-p.
14. Galkina EM, Utz SR. Fluorescence diagnostics in dermatology (review). Saratov Journal of Medical Scientific Research 2013; 9 (3): 566-72.
15. Pobilat АЕ. Combined use of dermatoscopy and fluorescence contact biomicroscopy in differential diagnostics of basal cell skin cancer: PhD abstract. Novosibirsk, 2010; 24 p.
16. Osipova ЕА. Fluorescent methods for study of tumors of eyelids and conjunctiva based on endogenous exogenous fluorophores: PhD abstract. Moscow, 2009; 24 p.

2020_02-1_587-591.pdf379.41 KB

No votes yet