Saratov JOURNAL of Medical and Scientific Research
Home

Oxidative stress and methods of its correction in corneal burns (review)

Year: 2020, volume 16 Issue: №2 Pages: 459-463
Heading: Ophtalmology Article type: Review
Authors: Kolesnikov A.V., Kirsanova I.V., Sokolova A.I., Ban E.M.
Organization: Ryazan State Medical University n.a. I.L.Pavlov
Summary:

The article presents actual ideas about the role of oxidative stress in the pathogenesis of corneal burns and methods of its correction. Corneal burns are rather common ophthalmic pathology. Corneal burns are difficult to treat, so they often lead to a decrease in visual acuity and, as a result, disability of young people. Despite the high antioxidant protection of the eye structures, under the influence of damaging environmental factors on the cornea (ultraviolet, chemicals, high temperatures, etc.), there is an increase in the concentration of free radicals with a decrease in the level of antioxidants — oxidative stress develops, aggravating damage to the cornea. Medicaments with antioxidant properties have shown their efficacy in the treatment of corneal burns.

Keywords: antioxidants, corneal burn, oxidative stress

Bibliography:
1. Armitage WJ. Preservation of Human Cornea. Transfus Med Hemother 2011; 38 (2): 143-7.
2. Kanyukov VN, Stadnikov AA, Trubina OM, et al. State of rehabilitation problem of patients with corneal pathology (review). Vestnik OGU 2012; (1): 192-4.
3. Bourne R, Flaxman S, Braithwaite T, et al. Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis. Lancet Global Health 2017; 5 (9): 888-97.
4. Ackland P, Resnikoff S, Bourne R. World blindness and visual impairment: despite many successes, the problem is growing. Community Eye Health Journal 2017; 30 (100): 71-3.
5. Neroev VV, Gundorova RA, Makarov PV. Eye burns: a guide for doctors. Moscow: GEOTAR-Media, 2013; 224 p.
6. Merle Н, Gerard М, Schrage N. Ocular burns. Journal Francaisd'Ophtalmologie 2008; 31 (7): 723-34.
7. Cai M, Zhang J. Epidemiological characteristics of work-related ocular trauma in southwest region of China. International Journal of Environmental Research and Public Health 2015; 12 (8): 9864-75.
8. Odilova GR, Ekrinova NE. Treatment of burns eye with drugs pathogenetic orientation. Bulletin of the Council of Young Scientists and Specialists of the Chelyabinsk Region 2016; 4 (3): 75-7.
9. Jensen SJK. Oxidative stress and free radicals. Journal of Molecular Structure: THEOCHEM 2003; (666-667): 387-92.
10. Wakamatsu TH, Dogru M, Ayako I, et al. Evaluation of lipid oxidative stress status and inflammation in topic ocular surface disease. Molecular Vision 2010; 19 (16): 2465-75.
11. Galli F, Piroddi M, Annetti C, et al. Oxidative stress and reactive oxygen species. Contributions to Nephrology 2005; (149): 240-60.
12. BilgihanA, Bilgihan K, YisO,etal. Effects of topical vitamin E on corneal superoxide dismutase, glutathione peroxidase activities and polymorphonuclear leucocyte infiltration after photorefractive keratectomy. Acta Ophthalmologica Scandinavica 2003; 81 (2): 177-80.
13. Absalikova DK, Nikitina AF, Nikitin NA. The antioxidant system of the visual analyzer and antioxidants used in ophthalmology (review). In: Materials of the scientific and practical conference on ophthalmic surgery with international participation. Ufa, 2011; p. 536-40.
14. Cejka С, Cejkova J. Oxidative Stress to the Cornea, Changes in Corneal Optical Properties, and Advances in Treatment of Corneal Oxidative Injuries. Oxidative Medicine and Cellular Longevity 2015; (1): 10.
15. Kolesnikov AV, Barenina Ol, Shchul'kin AV, et al. Local changes in the free radical status of the cornea at the experimental purulent ulcer. Eruditio Juvenium 2013; (1): 28-32.
16. Kubota М, Shimmura S, Kubota S, et al. Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Investigative Ophthalmology and Visual Science 2011; 52 (1): 427-33.
17. Cejkova J, Trosan P, Cejka C, et al. Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface. Experimental Eye Research 2013; 116 (2): 312-23.
18. Salman IA, KiziltuncA, Baykal O. The effect of alkali burn on corneal glutathione peroxidase activities in rabbits. Turkish Journal of Medical Sciences 2011; 41 (3): 483-6.
19. Artyukov AA, Glebko LI, Elyakov GB, et al. "Histochrom" for the treatment of inflammatory diseases of the retina and cornea: Patent RUS №2134107. 10.08.1999.
20. Chesnokova NB, Kost ОА, Nikol'skaya II, et al. Method of treatment of eye diseases accompanied by oxidative stress: Patent RUS №2577236. 10.03.2016. Byul. №7.
21. Zeng Р, Pi R-B, Li Р, et al. Fasudil hydrochloride, a potent ROCK inhibitor, inhibits corneal neovascularization after alkali burns in mice. Molecular Vision 2015; (21): 688-98.
22. Chesnokova NB, Beznos OV, Pavlenko ТА, et al. A comparative experimental study of the effect of 3-oxypyridine derivatives (Mexidol and Emoxipin) in eyedrops on local metabolism and healing of alkali burn wounds of various localizations of rabbit eyes. Report 1: Central cornea wounds. Russian Ophthalmological Journal 2013; 6 (3): 81-5.
23. Chesnokova NB, Beznos OV, Pavlenko ТА, et al. Effects of Hydroxypyridine Derivatives Mexidol and Emoxypin on the Reparative Processes in Rabbit Eye on the Models of Corneal Epithelial Defect and Conjunctival Ischemia. Bulletin of Experimental Biology and Medicine 2014; (9): 332-5.
24. Sekundo W, Augustin AJ, Strempel I. Topical allopurinol or corticosteroids and acetylcysteine in the early treatment of experimental corneal alkali burns: a pilot study. European Journal of Ophthalmology 2002; 12 (5): 366-72.
25. Shchul'kin AV, Yaskusheva EN, Davydov VV, et al. The study of the direct antioxidant activity of phytoecdysterone in vitro. I. P. Pavlov Russian Medical Biological Herald 2017; 20 (1): 52-8.
26. Sevostyanov АЕ, Sokolov VA, Mnikhovich MV. Comparison of the effectiveness of epithelizing substances in experimental corneal burns. I. P. Pavlov Russian Medical Biological Herald 2011; (19): 110-3.

AttachmentSize
2020_02_459-463.pdf341.36 KB
All articles of the authors: Ban E.V., Kirsanova I.V., Kolesnikov A.V. , Sokolova A.l.

No votes yet