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Clinical and immunological evaluation of pathological changes in the organ of vision in patients with open-angle glaucoma

Year: 2020, volume 16 Issue: №1 Pages: 237-241
Heading: Ophtalmology Article type: Original article
Authors: Malysheva Ju.V., Volkova N.V., Kursakova Ju.V.
Organization: Irkutsk State Medical Academy of Postgraduate Education, Irkutsk State Medical University, S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

The purpose is to perform clinical assessment of neurodegenerative and inflammatory changes in the visual organ in patients with advanced open-angle glaucoma and to identify the relationship between the degree of neurodegenerative and inflammatory changes. Material and Methods. Prospective examination of 26 patients with advanced open-angle glaucoma and 22 patients without changes in eye hydrodynamics with determination of TGF-p and MMR-9 concentrations in lacrimal and anterior chamber aqueous humor. Results. There was a statistically significant decrease in the concentration of MMR-9 in patients with glaucoma by 1.62 times in the lacrimal fluid (p<0.01) and by 2.17 times in the anterior chamber aqueous humor (p<0.05) in comparison with the control group. There was a statistically significant inverse relationship between MMP-9 in the lacrimal and the indicator characterizing a clinical picture of inflammatory reaction of the conjunctiva (p=0.02) and direct interdependence of the concentration of MMP-9 in the lacrimal and the thickness of the nerve fiber layer (p=0.02). Conclusion. The study revealed correlations between the degree of severity of the conjunctival inflammatory response, neurodegenerative changes, and the content of MMR-9 in the lacrimal and aqueous humor of the anterior chamber of patients with open-angle glaucoma.

Keywords: matrix metalloproteinase 9, open-angle glaucoma, transforming growth factor p

Bibliography:
1. Flammer J. The vascular concept of glaucoma. Surv Ophthalmol 1994; 38: 3-6; Hayreh SS. Progress in the understanding of the vascularetiology of glaucoma. Curr Opin Ophthalmol 1994; 5: 26-35.
2. Kurysheva Nl, Marnykh SA, Borzinok SA. Use of physiological reparation regulators in glaucoma surgery: a clinical and immunological study. The Russian Annals of Ophthalmology 2005; 6: 21-5.
3. Volkova NV, Shchuko AG, Malysheva JuV, Yuryeva TN. Inadequate reparative regeneration in fistulazing glaucoma surgery. Fyodorov Journal of Ophthalmic Surgery 2014; 3: 60-6.
4. Chang L, Cheng Q, Lee DA. Basic science and clinical aspects of wound healing in glaucoma filtering surgery. J Ocul Pharmacol Ther 1998; 14: 75-95.
5. Chang L, Crowston JG, Cordeiro MF, et al. The role of the immune system in conjunctival wound healing after glaucoma surgery. Surv Ophthtalmol 2000; 45: 49-68.
6. Avdeev RV, Aleksandrov AS, Basinskiy AS, et al. Clinical multicenter study of trabeculectomy efficacy. Glaucoma 2013; 2: 53-60.
7. Titov VN. The role of macrophages in the formation of inflammation, the effect of interleukin-1, interleukin-6 and the activity of the hypothalamic-pituitary system (literature review). Clinical Laboratory Diagnostics 2003; 12: 3-10.
8. Reynolds AC, Skuta GL. Clinical perspectives on glaucoma filtrering surgery: Antiproliferative agents. Ophthalmol Clin North Am 2000; 13 (3): 501-15.
9. Picht G, Welge-Luessen U, Grehn F, Lutjen-Drecoll E. Transforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development. Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie 2001; 239 (3): 199-207.
10.Zenkel M, LewczukP, JunemannA,etal. Proinflammatory cytokines are involved in the initiation of the abnormal matrix process in pseudoexfoliation syndrome glaucoma. Am J Pathology 2010; 176 (6): 2868-79. DOI: 10.2353/ajpath. 2010.090914.
11. Volkova NV, Yuryeva TN, Grishhuk AS. Correlation and correction factors for different types of tonometry: Biomechanics and biogeometry of the fibrous membrane of the eye: Report 2. National Journal of Glaucoma 2016; 15 (1): 37-45.

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