Hemostasiological and Theological parameters of blood in elderly and mature patients with ulcerative colitis
Year: 2020, volume 16 Issue: №1 Pages: 186-189
Heading: Тhematic supplement Article type: Original article
Authors: Tyultyaeva L.A., Mikhailova Е.А., Lipatova Т.Е., Alipova L.N.
Organization: Regional Hospital for War Veterans, Saratov, Saratov State Medical University
Heading: Тhematic supplement Article type: Original article
Authors: Tyultyaeva L.A., Mikhailova Е.А., Lipatova Т.Е., Alipova L.N.
Organization: Regional Hospital for War Veterans, Saratov, Saratov State Medical University
Summary:
Purpose: analysis of hemostasiological and rheological parameters of blood in elderly and mature patients with ulcerative colitis. Material and Methods. In 34 elderly patients and 32 mature patients with ulcerative colitis, we investigated the aggregation ability of platelet, antithrombogenic properties of the vascular wall, blood viscosity; erythrocyte aggregation index, erythrocyte aggregation index, erythrocyte deformability index, erythrocyte deformability index, and the efficiency of oxygen delivery to tissues were determined in comparison with similar indicators in healthy people. Results. In elderly patients with ulcerative colitis, as well as in patients of mature age, changes in the vascular-platelet link of the hemostatic system and blood rheology manifested by inhibition of anti-platelet activity of the vascular endo-thelium, changes in the functional activity of platelets and erythrocytes associated with the severity and activity of the process. Ulcerative colitis was accompanied by the development of the first (compensated) phase of the chronic form of DIC-syndrome. Conclusion. Elderly and mature patients with ulcerative colitis have disorders in the vascular-platelet link of hemostasis and blood rheology, manifested by inhibition of antithrombogenic activity of vascular endothelium, a change in platelet and red blood cell activity.
Bibliography:
1. Sovalkin VI,AkhmedovVA, BikbavovaGR, Emelyanova YuA. Modern views on the prevalence, risk factors and causes of ulcerative colitis. Experimental and clinical gastroenterology 2017; 146 (10): 110-115.
2. DenisovaTP,TyultyaevaLA.Geriatricgastroenterology: Selected lectures. Moscow: MIA, 2011; 336 p.
3. Razumova MS. Analysis of the prevalence of nonspecific ulcerative colitis and Crohn's disease in Kursk and Kursk region for the period from 2013 to 2018. Regional Bulletin 2019; 15 (30): 3-4.
4. Dolgushina Al, Khusainova GM, Vasilenko AG, Kononets VA. Prevalence of inflammatory bowel disease in the Chelyabinsk Region. Almanac of Clinical Medicine. 2019; 47 (6): 511-7.
5. Denisova ТР, Chernenkov YuV, Tyultyaeva LA, Shuldyakov VA. Mathematical gastroenterology. Saratov: SSMU, 2013; 300 p.
6. Lazebnik LB, Levchenko SB, Komissarenko IA. Colitis in internist practice. Therapy 2017; 3 (13): 25-8.
7. Fedulova EN, Shumilova OV, Khaletskaya OV, Prakhov AV. The state of the microvasculature and the cellular
composition of the colon mucosa in inflammatory bowel diseases in children. Experimental and clinical gastroenterology 2019; 167 (7): 29-33.
8. Litvinov Rl, Weisel JW. Role of red blood cells in haemostasis and thrombosis. International Society of Blood Transfusion, ISBT Science Series 2017; 12: 176-83.
9. Borota AV, Borota AA, Onishchenko EV. Thrombotic Complications in Inflammatory Bowel Disease. Russian Journal of Gastroenterology, Hepatology, Coloproctology 2019; 29 (2): 23-6.
10. Lishchinskaya AA, Kagramanova AV, Zvyaglova MYu, et al. Thromboembolic complications in patients with inflammatory bowel diseases. Pharmateca 2019; 26 (2): 10-9.
11. Livin GYa, Popovicheva AN, Sosnina LN, etal. Role of disorders of erythrocytes rheological properties in pathogenesis of inflammatory bowel diseases in children. Thrombosis, Hemostasis and Rheology 2017; 72 (4): 45-52.
12. Gorelov AV, Kanshina AA, Yablokova EA, et al. The coagulation system in children with inflammatory bower disease: disorders and treatment approaches. Questions of Practical Pediatrics 2018; 13 (4): 7-17.
13. Ramazanova AKh, Mustafin IG, Odintsova AKh, et al. Features of changes in the hemostatic system in patients with inflammatory bowel diseases. Experimental and Clinical Gastroenterology 2017; 146 (10): 40-5.
14. Baluda VP, Lukyanova TN, Baluda MV Method for determining the anti-aggregational activity of the vessel wall. Laboratory business 1983; 6: 17-20.
15. Parfenov AS, Peshkov AV, Dobrovolskiy NA. Blood analyzer rheological AKP-2: Methodical recommendations. Moscow, 1994; 136 p.
16. Stoltz JF, Donner М, Mueller S. Hemorheology in practice: an introduction to the concept of a hemorheological profile. Rev Port Hemorreol 1991; 5: 175-88.
| Attachment | Size |
|---|---|
| 2020-01-1_186-189.pdf | 286.51 KB |
Русский
English