Saratov JOURNAL of Medical and Scientific Research

№3, 2019, volume 15

Clinical and diagnostic significance of arterial stiffness in the early post-stroke period

Year: 2019, volume 15 Issue: №3 Pages: 769-773
Heading: Cardiology Article type: Original article
Authors: Mayorova S.V., Lipatova Т.Е., Haibekova T.V.
Organization: Saratov State Medical University
Summary:

The purpose of the study is the analysis of neurological functions' restoration in patients with hypertension in the early post-stroke period after ischemic stroke, depending on the parameters of vascular wall rigidity. Materials and Methods. The study included 50 patients with hypertension in the acute phase of ischemic stroke. Clinical, laboratory and instrumental studies were carried out on patients. Vascular wall rigidity was defined using the ankle-brachial index and stiffness index, as well as deficit neurological functions — using the NIHSS, MRS scales. Results. It is shown that high levels vascular wall rigidity is associated with marked shortage of neurological function in hypertensive patients in the early post-stroke period. Conclusion. Accounting indicators of vascular stiffness allow more accurate assessment of prognosis and help to develop personalized treatment strategy in patients with hypertension in the early post-stroke period after ischemic stroke.

Keywords: ankle-brachial index, arterial hypertension, stiffness, stroke

Features of total peripheral resistance and regional vascular resistance in arterial hypertension

Year: 2019, volume 15 Issue: №3 Pages: 763-769
Heading: Cardiology Article type: Original article
Authors: Lukyanov V.F., Kaplanova T.l., Broyaka N.A., Gompassunon O.M. M., Varezhnikova O.V., Potapova M.V.
Organization: Saratov State Medical University
Summary:

The purpose of the study is to conduct comparative analysis of brachial artery's total peripheral resistance and vascular resistance in patients with arterial hypertension. Material and Methods. We applied standard measurement techniques for total peripheral resistance and blood flow parameters of the brachial artery in 128 patients suffering from the arterial hypertension. Results. The peripheral blood flow condition depends on the following indicators: kinetic energy of blood release (Wkin), brachial artery volumetric bloodstream (Vbr) and radius (Rbr), total peripheral resistance (TPR) and peripheral resistance (PRbr) of the brachial artery. Based on these indicators the patients were split into three groups according to pathogenetic variants of the hypertonic disease. Conclusion. The proposed criteria of the bloodstream status allows to verify arterial hypertension pathogenetic mechanisms. It implies personalized approaches to treatment of patients with arterial hypertension.

Keywords: hemodynamic status, hypertensive disease, pathogenetic variants

Frailty and arterial hypertension (lecture)

Year: 2019, volume 15 Issue: №3 Pages: 757-763
Heading: Cardiology Article type: Lecture
Authors: Lipatova Т.Е., Tyultyaeva L.A., Denisova Т.Р., Shulpina N.Yu.
Organization: Saratov Regional Hospital for Veterans of Wars, Saratov State Medical University
Summary:

The lecture analyses reference data on the problem of combination of senile asthenia and hypertension in elderly and senile patients. It discusses modern views on the possibilities and problems of diagnosis and treatment of patients with a combination of senile asthenia and hypertension.

Keywords: arterial hypertension, frailty

Cardiovascular risk factors and arterial stiffness in patients with ulcerative colitis

Year: 2019, volume 15 Issue: №3 Pages: 753-757
Heading: Cardiology Article type: Original article
Authors: Lipatova Т.Е., Mihailova Е.А., Dudaeva N.G.
Organization: Saratov State Medical University
Summary:

Purpose: to assess cardiovascular risk factors and arterial stiffness in patients with ulcerative colitis (UC) without clinical manifestations of cardiovascular diseases. Material and Methods. 76 patients with remission of UC, 40 patients with irritable bowel syndrome and 25 healthy volunteers of comparable age and gender were examined. The 10-year risk of fatal cardiovascular events (SCORE) was calculated. Daily monitoring of arterial stiffness, endothelium function together with its vasodilative, vasoconstrictive and adhesive functions were evaluated in all examinees. Results. Traditional cardiovascular risk factors such as hypercholesterolemia, obesity or hypertension were not typical for patients with UC. Risk SCORE was low in the majority of UC patients. Patients with UC were characterized by the increase of intima-media complex thickness, C-reactive protein level, and by the decrease of HDL cholesterol. UC patients demonstrated the increase of arterial rigidity and endothelial dysfunction which reflected in statistically significant decrease of endothelium-dependent vasodilation to 11.48%, and increase of plasma levels of endothelin-1, vascular adhesion molecules VCAM-1 and ICAM-1. Conclusion. UC patients need multidisciplinary approach to study their arterial rigidity and markers of endothelial dysfunction.

Keywords: arterial stiffens, endothelial dysfunction, ulcerative colitis

Health of future and present time doctors from the standpoint of psychosomatic medicine: patterns and paradoxes

Year: 2019, volume 15 Issue: №3 Pages: 749-753
Heading: Cardiology Article type: Original article
Authors: Kodochigova A.l., Olenko E.S., Parshina S.S., Yuranova Yu.V., Puzakov K.K., Zhuk A.A., Subbotina V.G., Pavlishcheva I.D.
Organization: Saratov City Clinical Hospital No. 9, Saratov State Medical University
Summary:

The purpose of the study is to conduct comparative analysis of personal psychological characteristics of medical university students and doctors of a therapeutic profile to determine possible risks of developing psychosomatic diseases with subsequent recommendations for conducting personalized psychological correction of the revealed changes. Material and Methods. To achieve this goal 44 medical students (group I) and 36 doctors working in hospitals of the city (group II) were examined using the self-assessment С Spielberger — Y Khanin' anxiety scale, E. Heim's method of stress-coping behavior, and S. Dellinger's psychogeometric test. Results. It was revealed that the members of both groups had high levels of personal anxiety and were adaptive in the emotional coping sphere. Representatives of group I were distinguished by the presence of predominantly non-adaptive reactions in the cognitive sphere, however, they were constructive in designing stress-overcoming behavior proper, in contrast to representatives of group II. Medical university students were characterized by inconsistency of intrapersonal traits. Conclusion. Thus, it is advisable to recommend psychological correction of the revealed changes, i. e. to reduce high level of anxiety in both students and doctors; to increase adaptability among students in the cognitive sphere and among doctors in the behavioral sphere; to resolve intrapsychic conflicts in students to improve psychosomatic pathology prevention.

Keywords: adaptability, anxiety, doctors, stress coping behavior, students of Medical University

Distinctive features of psychological status for patients with various forms of coronary heart disease

Year: 2019, volume 15 Issue: №3 Pages: 744-749
Heading: Cardiology Article type: Original article
Authors: Kodochigova A.l., Kirichuk V.F., Sinkeev M.S., Bogdanova T.M., Olenko E.S., Filonenko E.V., Slyusarenko Yu.A., Dolgov A.A., Ilyin A.A.
Organization: Saratov State Medical University
Summary:

The purpose of the study is: to conduct comparative analysis of personal response characteristics in patients with stable and unstable forms of coronary heart disease, depending on the presence or absence of acute coronary disaster in their history. Materials and Methods. 94 men and women with an established diagnosis of coronary heart disease (CHD), aged 38 to 55 years were examined. All individuals under study were divided into 4 groups: two groups with stable forms of angina pectoris, and two groups with unstable angina pectoris, depending on the presence or absence of myocardial infarction history. The following tools were used to determine personal response characteristics in CHD patients: abbreviated multifactor personality questionnaire; Toronto alexithymic scale and psycho- geometric test. Re-sults. It was found that patients with coronary artery disease had a high level of neurotization, alexithymicity, conformity, pessimism, and low self-esteem, along with sociability, friendliness and desire to avoid conflict situations. Neurotic tendencies, alexithymicity and decreased activity were most pronounced in patients with history of acute coronary catastrophe (p<0.05). Conclusion. The results of the study determine advisability of including the methods of psychological correction of revealed changes in the complex of measures for secondary prevention of cardiovascular events in patients with various forms of coronary heart disease based on a personalized approach.

Keywords: alexithymia, cardiac infarction, coronary heart diseases, neurotization, psychological characteristics of a person

Amiodarone-induced skin damage: clinical observation

Year: 2019, volume 15 Issue: №3 Pages: 741-744
Heading: Cardiology Article type: Case report
Authors: Kosheleva N.A., Magdeeva N.A., Frontaseva V.V., Alekseeva I.L., Fedoritova M.O.
Organization: Saratov Regional Clinical Hospital, Saratov State Medical University
Summary:

Nowadays one of the most often used antiarrhytmic drugs is amiodarone. Amiodarone is the most effective drug for sinoatrial rate preservation at fibrillation of auricles, the only agent with the proved ability to reduce mortality in patients with cardial pathology and ventricular arrhythmias. On the other hand, amiodarone is the "reserve" drug due to its side effects. In this observation the patient was on amiodarone in the course of 5 years due to paroxysms of auricles fibrillation. After 4 years of drug therapy grayish-blue local areas appeared on open body parts (i. e. face, hands). After drug with drawal the intensity of skin staining decreased. In this clinical case skin hyperpigmentation was amiodarone side effect and did not require any special treatment.

Keywords: amiodarone, skin hyperpigmentation

To the 175th birth anniversary of Professor D. N. Zernov

Year: 2019, volume 15 Issue: №3 Pages: 725-729
Heading: Scientific schools and memorable dates Article type:
Authors: Nikolenko V.N., Shvedavchenko A.l., Oganesyan M.V., Aleshkina O.Yu., Fomkina O.A., Aliyeva F.F.
Organization: Saratov State Medical University
Summary:

In 2018 the foundation of the medical faculty of the Imperial Moscow University (presently I.M. Sechenov First Moscow State Medical University) turned the 260th anniversary. The name of Dmitry Nikolaevich Zernov is among the brightest names of Moscow University. In May 1869, D. N. Zernov was approved as an Associate Professor of the faculty of medicine for teaching anatomy and lecturing for students. D. N. Zernov made a significant contribution to the formation of the department of anatomy at our University, both in the development of new scientific directions, and in the formation of a productive educational process. D. N. Zernov paid special attention to the teaching process. Professor»s research interests combined with his undeniable talent as an organizer.

Keywords: Sechenov University, Professor, department of human anatomy, D. N. Zernov

Department of oncology at Razumovsky Saratov Medical University and Kunitsyna Research Society of Oncologists of the Saratov Region: History and Modernity (1968-2019)

Year: 2019, volume 15 Issue: №3 Pages: 721-724
Heading: Scientific schools and memorable dates Article type: Original article
Authors: Vertyankin S.V., Konopatskova О.М., Evdokimov G.M.
Organization: Saratov State Medical University
Summary:

The article is devoted to the activity of SSMU department of oncology and to the history and development stages of research society of oncologists named after T. A. Kunitsyna.

Keywords: department of oncology at Saratov Medical University n. a. V. I. Razumovsky, research society of oncologists

The 60th anniversary of Anatoliy P. Barabash's career

Year: 2019, volume 15 Issue: №3 Pages: 715-720
Heading: anniversary Article type:
Authors: Norkin I.A., Barabash Yu.A., Grishin S.E., Ulyanov V.Yu., Grazhdanov K.A.
Organization: Saratov State Medical University
Summary:

The article highlights the stages in the career of professor Anatoliy P. Barabash. It evaluates his scientific impact to the development of sciences of traumatology and orthopedics.

Keywords: academician Gavriil Abramovich llizarov, history of traumatology and orthopedics, professor Anatoliy Petrovich Barabash