Saratov JOURNAL of Medical and Scientific Research

The vascular- platelet and coagulation hemostasis in preeclampsia and gestational arterial hypertension in the third trimester of pregnancy

Year: 2019, volume 15 Issue: №2 Pages: 501-506
Heading: Ophtalmology Article type: Original article
Authors: Kolenko O.V., Chizhova G.V., Sorokin E.L., Fil A.A., Khodzhaev N.S., Pomytkina N.V.
Organization: Postgraduate Institute for Public Health Workers, The Khabarovsk branch of the S. Fedorov Eye Microsurgery Federal State Institution

Purpose: to conduct a retrospective analysis of the initial state of the indicators of systemic hemostasis in women during a complicated pregnancy, to determine its likely relationship with the formation of vascular retinal pathology in the long-term period after childbirth. Material and Methods. The 1st main group consisted of 47 women whose pregnancy proceeded against the background of gestational hypertension. The 2nd main group is represented by 48 women, whose pregnancy was complicated by pre-eclampsia. The control group was formed by 50 women with normal ongoing pregnancy. In women of all groups, the initial state of hemostasis was assessed in the third trimester of pregnancy, according to medical records. Results. It turned out that in women with hypertensive disorders in the third

1 Powe CE, Levine RJ, Karumanchi SA. Preeclampsia, a disease of the maternal endothelium: The role of antiangiogenic factors and implications for later cardiovascular disease. Circulation 2011; 123 (24): 2856–69. DOI: 10.1161 / CIRCULATIONAHA. 109.853127
2 Valdiviezo C, Garovic VD. Preeclampsia and hypertensive disease in pregnancy: their contributions to cardiovascular risk. Clinical Cardiology 2012; 35 (3): 160–5. DOI: 10.1002 / clc. 21965
3 Sidorova IS, Nikitina NA. Pathogenesis of endotheliosis in preeclampsia. Obstetrics and Gynecology 2015; (1): 72–8
4 Kolenko OV, Sorokin EL. A study of the possible causal relationship between the formation of acute vascular pathology of the eye in women and the transferred OPG-gestosis. Byulleten» SO RAMN 2009; (4): 85–7
5 Kolenko OV, Sorokin EL, Egorov VV, et al. Condition of macular retina in women at preeclampsia and after the delivery. Journal of Ophthalmology (Ukraine) 2015; (3): 47–53
6 Kolenko OV, Sorokin EL, Khodzhaev NS, et al. The efect of endothelial dysfunction on macular blood fow in pregnant women with preeclampsia during pregnancy and in the postnatal period. Modern technologies in ophthalmology 2019; (1): 281–4
7 Barkagan ZS. Diagnosis and controlled therapy of hemostatic disorders. Moscow: Newdiamed, 2012; 292 p.
8 Tikhomirova IA, Muravyov AV, Petrochenko EP, et al. The estimation of hemorealogical status and state of microcirculation in healthy persons and in patients with arterial hypertension. Regional blood circulation and microcirculation 2009; 8 (3): 38–42
9 Williamson TN, Lowe GD, Baxter GM. Infuence of age systemic blood pressure: Smoking and blood viscosity on orbital blood velocities. British Journal of Ophthalmology 1995; 79 (1): 17–22
10 Baev VM, Sharapova NV. Blood viscosity as regulator of arterial pressure level. Thrombosis, hemostasis and rheology 2011; (4): 10–4
11 Byshevsky ASh, Polyakova VA, Rudzevich AYu. Hemostasis in physiological pregnancy, pregnancy with arterial hypertension and preeclampsia. Thrombosis, hemostasis and rheology 2010; (4): 13–30
12 Bitsadze VO, Makatsariya AD, Hizroeva DH, et al. Thrombophilia as a most important link in the pathogenesis of pregnancy complications. Practical Medicine 2012; (5): 22–9
13 Tornton P, Douglas J. Coagulation on pregnancy. Best Practice and Research Clinical Obstetrics and Gynaecology 2010; 24 (3): 339–52
14 Shiphman EM. Preeclampsia, eclampsia, HELLP syndrome. Petrozavodsk: Intel Tech, 2002; 413 p.
15 Sidelnikova VM, Kiryushenkov PA. Hemostasis and pregnancy. Moscow: Triad-X, 2004; 206 p.
16 Makatsaria AD. Thrombohemorrhagic complications of obstetric and gynecological practice: a guide for doctors. Moscow: MIA, 2011; 1056 p.
17 Tyurina NA, Abramova SV, Dergunova YuA, et al. Sistemy state of hemostasis in pregnant women with gestational hypertension before and after delivery. The journal of scientifc articles «Health and Education Millennium» 2017; 19 (7): 66–8.

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