Saratov JOURNAL of Medical and Scientific Research

Mechanisms of optic nerve damage in patients with hemoblastosis

Year: 2019, volume 15 Issue: №2 Pages: 482-485
Heading: Ophtalmology Article type: Case report
Authors: Ioyleva E.E., Gadzhieva N.S., Zinovyeva A.V.
Organization: "Eye Microsurgery" n.a. academician S. N. Fedorov, Volgograd branch, Moscow State Medical Stomatological University n.a. A. I. Evdokimov

The development of optic neuropathy in leukemia and lymphomas has a wide range of etiological factors, being a result of neoplastic, infectious, compression, ischemic and toxic damage. Patients in the older age group may have cardiovascular risk factors that increase the risk of developing lesions of the optic nerve. Timely diagnosis of optic neuropathy in hemoblastosis and the choice of the optimal treatment method allow to maintain high visual function and improve patients» quality of life. The paper presents a clinical case of unilateral ischemic neuropathy in patients with clinical and hematological remission of acute myeloblastic leukemia and the presence of cardiovascular risk factors, as well as heart failure.

1 Brenner H, Kaatsch P, Burkhardt-Hammer T, et al. Long-term survival of children with leukemia achieved by the end of the second millennium. Cancer 2001; 92 (7): 1977–83
2 Ra YH, Park SY, Im SA, et al. Enhancement of Optic Nerve in Leukemic Patients: Leukemic Infltration of Optic Nerve versus Optic Neuritis. iMRI 2016; 20: 167–74
3 Grishina EE, Mamontov AO. Ophthalmic manifestations of leukemia. Almanac of Clinical Medicine 2016; 44 (5): 587–91
4 Soman S, Kasturi N, Srinivasan R, et al. Ocular Manifestations in Leukemias and Their Correlation with Hematologic Parameters at a Tertiary Care Setting in South India. Ophthalmology Retina 2018; 2 (1): 17–23
5 Reddy SC, Jackson N, Menon BS. Ophthalmologica 2003; 217 (6): 441–5
6 Koshy J, John MJ, Thomas S, et al. Indian J Ophthalmol 2015; 63 (8): 659–64
7 Kincaid MC, Green WR. Ocular and orbital involvement in leukemia. Surv Ophthalmol 1983; 27 (4): 211–32
8 Lin YC, Wang AG, Yen MY, et al. Leukaemic infltration of the optic nerve as the initial manifestation of leukaemic relapse. Eye 2004; 18 (5): 546–55
9 Myers KA, Nikolic A, Romanchuk K, et al. Optic neuropathy in the context of leukemia or lymphoma: diagnostic approach to a neuro-oncologic emergency. Neuro-Oncology Practice 2017; 4 (1): 60–6
10 Killer HE, Jaggi GP, Flammer J, et al. Cerebrospinal fuid dynamics between the intracranial and the subarachnoid space of the optic nerve. Is it always bidirectional? Brain 2007; 130 (2): 514–20
11 Bhatt UK, Gregory ME, Madi MS, et al. Sequential leukemic infltration and human herpes virus optic neuropathy in acute lymphoblastic leukemia. J AAPOS 2008; 12 (2): 200–2
12 Zaman AG, Graham EM, Sanders MD. Anterior visual system involvement in non-Hodgkin»s lymphoma. Br J Ophthalmol 1993; 77 (3): 184–7
13 Schulmann S, Pochon C, Colne J, et al. Retrobulbar Optic Neuritis Associated with Tacrolimus Decrease after Allogeneic hematopoietic Stem Cell Transplantation for Acute Myeloblastic Leukemia Patient. J Clin Cases Rep 2018; 1 (1): 30–5.14 Iwami T, Nishida Y, Mukaisho M, et al. Central Retinal Artery Occlusion Associated with Leukemic Optic Neuropathy. Journal of Pediatric Ophthalmology and Strabismus 2003; 40 (1): 54–6
15 García-Fernández M. Arteritic anterior ischemic optic neuropathy associated with chronic myelomonocytic leukemia (cmml): a case report. The Pan-American Journal of Ophthalmology 2014; 13 (4): 121–3
16 Kuo J. Bilateral nonarteritic anterior ischemic optic neuropathy (NAION) complicated with chronic lymphocytic leukemia infltration (CLL). American Academy of Optometry. URL: / detail / knowledge-base-article / bilateral-nonarteritic-anterior-ischemic-optic-neuropathy-naion-complicated-chronic-lymphocytic (2012)
17 Schif D, Kesari S, Wen P. Cancer Neurology in Clinical Practice: Neurologic Complications of Cancer and its Treatment (2nd ed.). Br J Cancer 2009; 100 (6): 1020
18 Mathew DJ, Arthur A, John SS. Presumed Chemotherapy-Induced Optic Neuropathy and Maculopathy: A Case Report. Open Ophthalmol J 2017; 11: 298–304
19 Margileth DA, Poplack DG, Pizzo PA, et al. Blindness during remission in two patients with acute lymphoblastic leukemia: a possible complication of multimodality therapy. Cancer1977; 39 (1): 58–61.

2019_02-1_478-482.pdf281.67 KB

No votes yet