Saratov JOURNAL of Medical and Scientific Research

Evaluation of the efcacy of neuroprotective therapy after endovitreal surgery for rhegmatogenous retinal detachment

Year: 2019, volume 15 Issue: №2 Pages: 460-464
Heading: Ophtalmology Article type: Original article
Authors: Egorov A.V., Egorov V.V., Smoliakova G.P.
Organization: The Khabarovsk branch of the S. Fedorov Eye Microsurgery Federal State Institution

 Purpose: to develop optimal approaches to the use of cytofavin for neuroprotection and to evaluate their efective-ness in patients after endovitreal surgery for rhegmatogenous retinal detachment (RRD) with anatomically complete retinal attachment. Material and Methods. 68 people (68 eyes) with primary RRD. Three-port vitrectomy with silicone oil tamponade in the vitreous cavity and its subsequent removal were performed. The patients were divided into 2 groups: the main group (38 people who received cytofavin added to standard therapy), and the control group (30 people with standard therapy only). Depending on visual prognosis calculated before surgery, the main and control groups consisted of patients with tolerable and low levels of visual prognosis. We used laser doppler fowmetry (to register microcirculation index (MI) and microcirculation efciency index (MEI)). Morphological signs of macular ischaemia were recorded by optical coherence tomography angiography (OCT-angiography). Results. Regardless of visual prognosis, the response dynamics of the chorioretinal microcirculation in patients was unidirectional. In patients of the main group 6 months after the surgery, more signifcant positive changes in growth of amplitude of MI and MEI, as well as positive dynamics of OCT-angiography were observed. Conclusion. Including cytofavin neuroprotection in postoperative treatment in patients after

1 Smirnov EV. The peculiarity of the local infammatory process in rheumatogenic retinal detachment and its correction: PhD abstract. Novosibirsk, 2011; 24 p.
2 Mitry D, Charteris DG, Yorston D, et al. Rhegmatogenous retinal detachment in Scotland: research in design and methodology. BMC Ophtalmol 2009; (9): 2
3 Bayborodov YaV. Prediction of functional outcomes of vitreoretinal surgery: PhD abstract. St. Petersburg, 2006; 24 p.
4 Mashchenko NV, Khudyakov AYu, Lebedev YaB, et al. The comparative analysis of surgical treatment of primary rheumatogenic retinal detachment by methods of episkleral and vitreal surgery. Modern technologies in ophthalmology 2014; (1): 77–8
5 Colucciello M, Rasier R. Rhegmatogenous retinal detachment. Phys Sportsmed 2009; 37 (2): 59–65
6 Zavgorodnyaya NG. The hemodynamic background in patients with rhegmatogenous retinal detachment. Zaporozhye Medical Journal 2014; (5): 66–9
7 Zaika VA. Pato- and sanogenetic mechanisms determining the outcome of surgical treatment of retinal detachment: PhD abstract. Irkutsk, 2015; 24 p.
8 Suslina ZA, Tanashyan MM, Smirnova IN, et al. Antioxidant and neurotrophic efects of Cytofavin in chronic cerebrovascular diseases. Herald of the St. Petersburg State Medical academy 2002; (3): 110–4
9 A method for predicting postoperative visual acuity in endovitreal surgery of rheumatogenic retinal detachment: Patent of Russian Federation 2654585 / Egorov AV (RU), Smoliakova GP (RU), Egorov VV (RU), Pashentsev YaE (RU); 21.05.2018, Bulletin No. 15
10 Egorova EN. The use of ozone therapy in rehabilitation period in patients operated on for rheumatogenic retinal detachment: DSc abstract. Moscow, 2007; 25 p.
11 Ivanov SV, Mashkovtsev VM, Cherygova EG. The frst experience of using retinalamin in complex treatment of patients with rheumatogenic retinal detachment. In: Modern technologies in treatment of vitreoretinal pathology — 2010: Abstract book. Moscow, 2010; p. 51–2
12 Karazhaeva MI, Saksonova EO, Klebanov GI, et al. Flavonoid antioxidants in the complex treatment of patients with dystrophic retinal detachment. RMJ: Clinical ophthalmology 2004; 5 (1): 41–3
13 Gusev AN, Krasnogorskaya VN. Antioxidants in complex treatment of far-advanced open-angle glaucoma. The Russian Annals of Ophthalmology 2016; 132 (1): 63–7
14 Uni Burauy. Metabolic therapy in the complex treatment of patients with partial atrophy of the optic nerve of secondary origin: PhD abstract. St. Petersburg, 2005; 24 p.

2019_02-1_460-464.pdf310.21 KB

No votes yet