Saratov JOURNAL of Medical and Scientific Research

Hormonal and lipid imbalances in the formation of myopic chorioretinal neovascularization in women

Year: 2019, volume 15 Issue: №2 Pages: 447-451
Heading: Ophtalmology Article type: Original article
Authors: Grigorieva A.V., Shchuko A.G., Kursakova Yu.V., Ivanova E.l., Samsonov D.Yu.
Organization: Irkutsk State Medical University, The S. Fyodorov Eye Microsurgery Federal State Institution

Purpose: to determine the role of hormonal and lipid imbalance in the formation of myopic chorioretinal neovascularization in women. Material and Methods. The frst clinical group includes the results of the study of patients with the active form of myopic chorioretinal neovascularization, the second — the results of the study of their paired eyes. The control groups were formed separately. Ophthalmologic and somatic status of all patients and people in the control groups were thoroughly examined. Results. An increase in the level of prolactin to 501.7±28.2 mlU/ml was established, in the control group to 272.9±33.4 mlU/ml, the level of follicle-stimulating hormone 13±0.1 mlU/ml, the control group 4,6±1.2 mlU/ml. The concentration of estradiol is reduced 35.2±3.1 pg/l, progesterone 2.8±0.1 nmol/l, compared to the control group 66.8±8.1 and 6.2±1.1 nmol/l respectively. An increase in the level of acute-phase proteins was revealed: fibrinogen 3.8 (14.0±0.5) and C-reactive protein 2 times (5.72±2.30) compared with the control group 3.6±0.5 and 2.5±0.7. Increased lipoprotein level (a) 50.2±1.2 g/l and ApoB/ApoA 0.6±0.1 compared with the control group 9.1±1.1 et 0.4±0.1 g/l. Conclusion. The fndings confrm the pathogenetic signifcance of systemic risk factors in the development of choroidal dysfunction and, as a

1 Iuryeva TN, Grigorieva AV, Pyatova YuS. Myopia and its complications. Bulletin of the East-Siberian Scientifc Center of the Siberian Branch of the Russian Academy of Medical Sciences 2015; 6 (106): 75–82
2 Wong T Y, Ferreira A, Hughes R, et al. Epidemiology and disease burden of pathologic myopia and myopic choroidal neovascularization: an evidence-based systematic review. Am J Ophthalmol 2014; 157: 9–25
3 Ohno-Matsui T. Myopic Choroidal Neovascularization. In: Ophthalmology: Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics. Springer Nature Switzerland, 2006; p. 430–86
4 Ohno-Matsui K, Yoshida T, Futagami S, et al. Patchy atrophy and lacquer cracks predispose to the development of choroidal neovascularization in pathological myopia. Br J Ophthalmol 2003; 87: 570–3
5 Silva R. Myopic maculopathy: a review. Ophthalmologica 2012; 228: 197–213
6 Wolf S, Balciuniene VJ, Laganovska G, et al. Radiance: a randomized controlled study of ranibizumab in patients with choroidal neovascularization secondary to pathologic myopia. Ophthalmology 2014; 121: 682–92
7 Averyanov DA, Alpatov SA, Zhukova SI, et al. Optical coherent tomography in the diagnosis of eye diseases. Moscow: GEOTAR-Media, 2010; 128 p.
8 Grigorieva AV, Iuryeva TN, Kursakova YuV, Ivanova EI. The role of changes in hormonal status in the formation of myopic chorioretinal neovascularization. Modern technology in ophthalmology 2017; 4: 61–4
9 Kobayashi K, Mandai M, Suzuma I, et al. Expression of Estrogen Receptor in the Choroidal Neovascular Membranes in Highly Myopic Eyes. Retina 2002; 22: 418–22.

2019_02-1_447-451.pdf406.6 KB

No votes yet