Saratov JOURNAL of Medical and Scientific Research

Endothelial dysfunction in burn injury

Year: 2019, volume 15 Issue: №2 Pages: 377-379
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Morrison V.V., Bozhedomov A.Yu., Morrison A.V.
Organization: Russian State Medical University, Saratov State Medical University

Objective: to estimate the level of markers of endothelial dysfunction in burn injury of various severities. Material and Methods. 57 patients were included in the study. The level of vascular endothelial growth factor (VEGF), endothe-lin, nitric oxide metabolites (NO), and the amount of circulating desquamated endothelial cells were determined in the dynamics of burn injury development. Results. In burn injury there was an increased amount of endothelial dysfunction markers in blood, which is highly expressed on the 7-15th day. Moreover on the 7th day in case of severe and extremely severe burn injury the level of VEGF was increased over 50 times while the amount of endothelin, nitric oxide metabolites and circulating desquamated endothelial cells becomes higher in 3–5 times. Conclusion. The research outcomes have proved the damage of endothelial lining in burn injury.

1 Alekseev AA, Tyurnikov YuI. Statistical indicators of the work of burn hospitals in the Russian Federation for 2009 Combustiology 2011; 4 URL:
2 Sokolov VA, Skvortsov YuR. Foreign burn statistics. Emergency 2011; 3: 58–61
3 Cakir B, Yegen BC. Systemic responses to burn injury. Turk J Med Sci 2004; 34: 215–26
4 Shapiro NI, Schuetz P, Yano К, еt al. The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Critical Care 2010; 14 (5): 182–93
5 Morrison VV, Bozhedomov AYu, Simonyan MA, Morrison AV. Systemic infammatory response and cytokine profle in the dynamics of burn disease. Saratov Journal of Medical Scientifc Research 2017; 13 (2): 229–32
6 Ferrata N, Gerber HP, Le Couter J. The biology VEGF and its receptors. Nat Med 2003; 9: 669–76
7 Lapshina LA, Kravchun PG, Titova AYu, Glebova OV The signifcance of the determination of nitrite-nitrates as markers of endothelial dysfunction in cardiovascular pathology. Ukrainian Medical Chronicle 2009; 6 (74): XI–XII. URL: / article / 2939 /
8 Petrischev NN, Vlasov TD. Typical forms of endothelial dysfunction. In: Chereshnev VA, Litvitsky PD, Tsygan VN, eds. Clinical Pathophysiology. St. Petersburg: Special Lit, 2012; p. 166–79
9 Petrischev NN, Berkovich OA. The diagnostic value of determining desquamated endotheliocytes in the blood. Clinical laboratory diagnosis 2001; 1: 50–2
10 Zilan A, Cetinkale O, Kiran B, et al. The role of supplementation or inhibition of nitric oxide production in burn injury to reduce ischemic damage. Ulus Travma Derg 2003; 9 (3): 169–75
11 Bao P, Kodra A, Tomic-Canic M, et al. The role of vascular endothelial growth factor in wound healing. J Surg Res 2009; 153 (2): 347–58. 12 Vlasov TD, Petrischev NN. Endothelial dysfunction: Causes, mechanisms and pharmacological correction. In: Physiology and pathophysiological endothelium. St. Petersburg: SPbGMU, 2003; 4–38
13 Dubas IA, Nemtsov ML, Akulenok AV. The number of circulating endothelial cells in patients with arterial hypertension of II degree in the treatment of certain ACE inhibitors. In: Materials of the 66th All-Russian Scientifc Conference n. a. N. I. Pirogov. Tomsk, 2007; p. 182–4
14 Foresta C, Schipilliti M, De Toni L. Blood levels, apoptosis, and homing of the endothelial progenitor cells after skin burns and escharectomy. J Trauma 2011; 70 (2): 459–65
15 Kung CT, Su CM, Chen CT, et al. Circulating endothelial progenitor cells may predict outcomes in adult patients with severe sepsis in the emergency department. Clin Chim Acta 2016; 455: 1–6. DOI: 10.1016 / j. cca. 2016.01.015.

2019_02_377-379_1.pdf262.69 KB

No votes yet