Saratov JOURNAL of Medical and Scientific Research

Pathophysiological evaluation of common neonatal factors of the pathogenesis of hemolytic anemia and infammation

Year: 2019, volume 15 Issue: №2 Pages: 372-376
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Geraskin V.A., Potemina T.E., Geraskin I.V., Komlev D.Yu.
Organization: Privolzhskiy Research Medical University

Objective: to determine the damage of blood elements as tissue damage — to study hemolytic anemia from the position of infammation. Material and Methods. Clinical and laboratory data of 187 neonatal patients were included in the examination group. The dynamics of blood erythrocyte indices was studied taking into account the dependence on age, anthropometric parameters, the severity of diseases and the intensity of oxygenotherapy. The composition and features of oxidative modifcations of lipid structures of biological membranes of erythrocytes were investigated. Results. The values of the elements of alteration in the pathogenesis of hemolysis were determined. Changes of erythrocyte membranes in oxidative hemolysis were investigated. The review and comparison of the information contained in the classical and periodicals on pathological physiology, Hematology. Conclusion. The study damage to the blood elements as tissue damage allows you to apply for the study of hemolytic anemias the concept of development of infammation.

1 Zaychik ASh, Churilov LP. Mechanisms of development of diseases and syndromes. St. Petersburg: ELBI-SPb, 2002; 507 p.
2 Mazurin AV, Vorontsov IM. Propedeutics of childhood diseases. Moscow: Medicine, 1985; 246 p.
3 Shevchenko EA, Lyalyayev VA, Potemina TE. Hypoxia and hyperoxia in questions and answers. N. Novgorod, 2013; p. 27– 8
4 Jоgers J, Brauckmann S, Kirsch M, et al. Moderate glucose supply reduces hemolysis during systemic infammation. Journal Infamm Res Mar 2018; 11: 87–94
5 Graca-Souza AV, Arruda MA, de Freitas MS, et al. Neutrophil activation by heme: implications for infammatory processes. Journal Blood 2002 Jun; 99 (11): 4160–5
6 Morrison VV, Chesnokova NP. Pathological physiology. Saratov, 2008; 334 p.
7 Belcher JD, Chen C, Nguyen J, et al. Haptoglobin and hemopexin inhibit vasoocclusion and infammation in murine sickle cell disease: Role of heme oxygenase-1 induction. URL: / 10.1371 / journa l. pone. 0196455 (25 Apr 2018)
8 Pendergrast J, Willie-Ramharack K, Sampson L, et al. The role of infammation in intravenous immune globulin-mediated hemolysis. Journal Transfusion 2015 Jul; 55S2: 65–73
9 L'Acqua C, Hod E. New perspectives on the thrombotic complications of haemolysis. British Journal of Haematology 2015 Jan; 168 2: 175–85
10 Ramos-Casals M, Garcнa-Carrasco M, Lуpez-Medrano F, et al. Severe autoimmune cytopenias in treatment- naive hepatitis C virus infection: clinical description of 35 cases. Journal Medicine 2003 Mar; 82 (2): 87–96
11 Vogel S, Thein SL. Platelets at the crossroads of thrombosis, infammation and haemolysis. British Journal of Haematology 2018 Mar; 180 (5): 761–7
12 Geraskin VA, Geraskina NV, Kuznetsova SV. Features of lipid composition of red blood cells of newborns. Medical Almanac 2010; 11 (2): 96–7.

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