Experimental substantiation of the results of combined techniques in treatment of soft tissue abscess
Year: 2019, volume 15 Issue: №2 Pages: 287-290
Heading: Surgery Article type: Original article
Authors: Alipov V.V., Kulikova A.N., Musaelyan A.G., Mustafayeva D.R.
Organization: Saratov State Medical University
Heading: Surgery Article type: Original article
Authors: Alipov V.V., Kulikova A.N., Musaelyan A.G., Mustafayeva D.R.
Organization: Saratov State Medical University
Summary:
Objective: to develop a model of purulent abscess of soft tissues and experimentally substantiate the efectiveness of the use of nanoparticles of zinc oxide (ZОN) and a drug based on lanthanum nitrate in the combined treatment of purulent abscess of soft tissues. Material and Methods. The purulent abscess of soft tissues modeling was performed using a modifed Fogarty catheter using a culture of Staphylococcus aureus in an experiment on 80 white laboratory rats of males weighing 190±25 g. Four groups of animals (20 each) were selected, which, after surgical dissection and laser rehabilitation of the cavity, carried out local therapy. In the frst (control) group, standard treatment was used, in the second group a drug based on lanthanum nitrate was used, in the third — ZОN, in the fourth — a combination of the drug with lanthanum nitrate + ZОN. Results. By the 10th day, 87±4.9 % of animals of the fourth group showed activation of the processes of collagenosis and epithelialization and complete obliteration of the abscess cavity. Conclusion. The developed purulent abscess of soft tissues modeling method is low-impact and allows optimizing the time of abscess formation with specifed characteristics. The combined treatment of animals of the fourth group due to the synergism of action creates optimal conditions for the accelerated obliteration of the purulent abscess of soft tissues cavity, shortening the treatment time by two times compared with the standard techniques.
Bibliography:
1 Gostishchev VK. General surgery. Moscow, 2015; 728 p.
2 Gostishchev VK. Clinical operative purulent surgery: a guide for physicians. Moscow, 2016; 448 p.
3 Shulutko AM, Osmanov EG, Gogokhiya TR, Khmyrova SE. The use of plasma fows in patients with surgical
infection of soft tissues. Bulletin of Surgery n. a. I. I. Grekov 2017; 176 (1): 65–9
4 Alipov VV, Dobrejkin EA, Urusova AI. Experimental laser nanosurgical technologies: First results and prospects. Journal of Experimental and Clinical Surgery 2011; 4 (2): 330–3
5 Method for modeling soft tissue abscess in experiment: Pat. 2601378 (RF), MPK G09V 23/28/Alipov VV, Urusova AI, Andreev DA, Kuliev NH (RF). №2015120118/14; declared 27.05.2015; published 10.11.2016. Bul. №31
6 The method of combined treatment of abscesses in the experiment: Pat. 2475251 (RF), MPK A61 K33/34, A61 P31/02, A61 N5/067/V. V. Alipov, M. S. Lebedev, S. Ju. Doronin [i dr.] (RF). №2012104033/14; declared 06.02.2012; published 20.02.2013. Bul. № 5
7 Blatun LA, et al. Eplan (ointment, solution) is a new drug for the local treatment of infections of the skin and soft tissues in a multidisciplinary hospital. Wounds and wound infections 2014; 1 (1): 13–21
8 Nikolenko VN, Alipov VV. Promising nanotechnology in the feld of experimental medicine. Nanotechnology 2009; (19): 66–8
9 Dwivedi S, Wahab R, Khan F, et al. Reactive oxygen species mediated bacterial bioflm inhibition via zinc oxide nanopar-ticles and their statistical determination. PLoS One 2014 Nov 17; 9 (11): e111289.
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