Saratov JOURNAL of Medical and Scientific Research

Congenital megakaryoblastic leukemia: A clinical case

Year: 2019, volume 15 Issue: №1 Pages: 34-40
Heading: Pediatrics Article type: Case report
Authors: Nechaev V.N., Chernenkov Yu.V., Mishina O.A., Fedorova Yu.A., Averyanov A.P.
Organization: Clinical Perinatal Center of the Saratov Region, Saratov State Medical University

Leukemia in children (leukemia) is a systemic hemoblastosis, accompanied by a violation of bone marrow hemato- poiesis and replacement of normal blood cells with immature blast cells of the leukocyte series. Acute megakaryoblastic leukemia-one of the rarest forms of acute leukemia (1-3% of all leukaemias), which is characterized by the presence in the blood and bone marrow, along with undifferentiated blasts also megakaryoblasts, ugly megakaryocytes and platelet clusters. The work presents a clinical case of congenital acute megakaryoblastic leukemia in the child S., combined with the mosaic form of Down syndrome and a congenital heart defect.

1 Volkova MA. Clinical Hematology. Moscow, 2001; p. 122-41
2 Bulatov VP, Cherezova IN, Makarova TP, et al. Hematology in childhood. Rostov n/D: Phoenix, 2006; p. 113-70
3 Lorsbach RB. Megakaryoblastic disorders in children American Society for Clinical Pathology. Am J Clin Pathol 2004; 122(1): 33-46
4 Lugovskaya SA, Pochtar ME. Hematology Atlas. 3rd edition, updated. Moscow; Tver: Triada, 2011; 368 p.
5 Barkhash PA. Patient Care and Medical Technology. Moscow: Medgiz, 1948; 264 p.
6 Verschuur AC. Acute megakaryoblastic. In: Orphanet Encyclopedia, 2004; p.1-5
7 Volodin NN. Neonatology (national leadership). Moscow: GEOTAR-Media, 2013; 896 p.
8 Mitsiakos G, Giougi Е. Haemostatic profile of healthy premature small for gestational age neonates. Thrombosis Research 2010; (126): 103-6
9 Kozarezova Tl, Klimkovich NN. Primary myelodysplastic syndromes in children (modern views on carcinogenesis, epidemiology and etiology, clinical and diagnostic aspects, therapeutic areas): textbook for physicians. Minsk: BelMAPO, 2005; 56 p.
10 Volodin NN. Problems of pharmacotherapy in neonatology. In: Issues of Modern Pediatrics: Materials of scientific-practical conference of pediatricians of Russia. Moscow, 2003; p. 23-5
11 Timakhov AM. Long-term results of therapy of acute leukemia in children: DSc diss. Moscow, 2003; 198 p.
12 Metkevich GL, Mayakova SA. Leukemia in children. Moscow: Practical medicine, 2009; 384 p.
13 Shabalov Nl, Ivanov DO, Shabalova NN. Hemostasis in the dynamics of the first week of life as a reflection of the mechanisms of adaptation in the prenatal life of a newborn. Pediatrics 2000; (3): 84-91.

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