Saratov JOURNAL of Medical and Scientific Research

2019, volume 15

Intense light deprivation as a factor in stress disorders of behavioral reactions and cognitive functions in the experiment

Year: 2019, volume 15 Issue: №2 Pages: 363-368
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Antipova O.N., Ivanov A.N., Zlobina O.V., Kirichuk V.F., Surovtseva K.A., Ankina V.D., Bondar G.D., Zenkina T.M., Polyukova M.V.
Organization: Saratov State Medical University
Summary:

Objective: to study the efect of light desynchronosis on behavioral reactions and cognitive functions of white male rats. Material and Methods. The study was conducted on 36 intact non-pedigree white male rats, which were divided into 2 groups: experimental and control. Animals were exposed to artifcial illumination 24 hours a day provided by the fuorescent lamp of 60 kW capacity. The same animals of the experimental group on the 10th, 21st and 30th days were tested in the installations «Dark-light camera» and «Open feld». Results. On the 10th day of intensive light deprivation, the indicators refecting the research-orientation activity reached the maximum values, which indicated the development of stress damage to the animal organism. On the 21st day of the experiment, the

Keywords: pneumocysts
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Structure of condylar cartilage in white rats after 60-day sodium benzoate intake and exposure to ionizing radiation

Year: 2019, volume 15 Issue: №2 Pages: 358-362
Heading: Human anatomy Article type: Original article
Authors: Stepanenko I.G., Luzin V.I.
Organization: St. Luke Lugansk State Medical University
Summary:

Aim of the study is to investigate the structure of condylar cartilage of mandible in rats after 60-day of sodium ben-zoate intake and ionizing radiation exposure both separately and simultaneously and fnd possibility of correction of the alterations found with sea-buckthorn oil. Material and Methods. The study involved 240 white rats distributed into 8 groups. Animals received intragastric sodium benzoate in dosage of 1500 mg / kg of body weight and were exposed to ionizing radiation (total 4 Gr. in 4 sessions). Sea-buckthorn oil was used as the correction drug (300 mg / kg of body weight). Morphometry of the condylar cartilage included zones morphometry and relations of volume components. Results. Application of sodium benzoate resulted in the narrowing of proliferation and subchondral osteogenic zones and the decrease of amount of primary spongiosa and osteoblasts; in readaptation period the structure of the cartilage was gradually restored. Ionizing radiation led to similar alterations while restoration period was longer. Action of both sodium benzoate and ionizing radiation resulted in severe alteration with no restoration observed. Application of sea-buckthorn oil resulted in faster restoration of cartilage structure. Conclusion. Combined action of sodium benzoate and ionizing radiation resulted in severe alterations of the mandibular condylar cartilage structure. Application of sea-buckthorn oil reduces negative efects of the experimental conditions on morphological functional features of the mandibular condy-lar cartilage.

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Optimization of the process of creating models of human blood vessels

Year: 2019, volume 15 Issue: №2 Pages: 353-357
Heading: Human anatomy Article type: Original article
Authors: Dol A.V., Ivanov D.V., Fomkina O.A.
Organization: Saratov National Research University n.a. N. G. Chernyshevsky, Saratov State Medical University
Summary:

Objective: to optimize the process of biomechanical modeling of blood vessels on the example of creating models of the arterial circle of the brain. Material and Methods. Biomechanical modeling requires the creation of a patient-oriented three-dimensional solid-state geometric model of the object under study. This problem can be solved by computer data processing (CT) or magnetic resonance (MRI) tomography. A program that implements the construction of blood vessel contours on individual sections of MRI in semi-automatic mode. These contours are exported as saved curves in a specifc format to SolidWorks, where they are used to create three-dimensional models of blood vessels. The models obtained in this way take into account the personal characteristics of the structure of the vascular bed of a particular patient and can be used in the process of biomechanical modeling. Results. The results of the program implementation of the recursive frontal growth method for processing two- dimensional slices of tomograms are presented. Conclusion. The developed software allows semi- automatic loading of DICOM images and obtaining fat sections of vessels on their basis, as well as transferring them for further processing into computer-aided design systems.

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Transformation of the personal identifcation system in the context of severe somatic disease

Year: 2019, volume 15 Issue: №2 Pages: 347-352
Heading: Sociology of Medicine Article type: Original article
Authors: Orlova M.M.
Organization: Saratov National Research University n.a. N. G. Chernyshevsky
Summary:

Resocialization of persons in a situation of illness determines one of the most important tasks of a health care system, namely, restoration of social opportunities of a patient. Objective: psychological analysis of identity system transformation of identifcations in a situation of a severe physical disease. Material and Methods. The study included a random sample of men and women aged 18–65: patients with ischemic heart disease (IHD) (n=116), and the control group (n=181). The following methods have been used: questionnaire, personal self-conception survey by S. R. Panteleev; R. Lazarus» study coping strategies; «Life style index»; family environment scale (FES) adapted by S. Y. Kupriyanov; WHO Quality of Life Questionnaire (WHOQOL); M. Kuhn»s test «Who am I?»; J. Rotter»s subjective control level test questionnaire; V. N. Dovlatova»s questionnaire for identifying cognitive inclination to dependency. Results. Signifcant diferences (p=0.01) in expression of identity indicators were obtained, which allowed to identify features of identifcation system characteristic of patients with ischemic heart disease without disability and with disability. Diferences in identifcation predictors with social roles, physical characteristics, negative self-identifcation and total number of self-descriptions were identifed using the regression analysis data. Conclusion. Change of personality of a patient with ischemic heart disease can be interpreted as othering and leads to difculties in social interactions and loss of opportunity to rely on their own personality, which requires psychotherapy. Socialization as a basic characteristic of modern society defnes one of the most important tasks of medical and social assistance to the population, namely, the restoration of the social capabilities of the patient. An analysis of the internal picture of the disease in patients with chronic somatic diseases in a social context makes it possible to determine the tasks of re-socialization in a situation of disability.

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Assessment of behavioral risk factors for chronic non-communicable diseases among medical students

Year: 2019, volume 15 Issue: №2 Pages: 342-347
Heading: Sociology of Medicine Article type: Original article
Authors: Balashova М.Е., Shemetova G.N., Gubanova G.V.
Organization: Saratov State Medical University
Summary:

Aim: assessment of risk factors for chronic non-communicable diseases in medical students to improve measures for the formation of a healthy lifestyle. Material and Methods. In order to identify risk factors for chronic non-communicable diseases, a questionnaire method was used. A survey included 80 frst- year students and 80 sixth-year students of medical school. The questionnaire included information about the sex, age, smoking and alcohol consumption, physical activity, and nutrition. Results. Respondents are characterized by a high frequency of risk factors for chronic non-communicable diseases (СNCD): low physical activity (60.0 %), poor diet (81.0 %), smoking (16.2 %). The combination of risk factors for the development of СNCD was revealed in 31.8 % of students. Conclusion. The high frequency of risk factors for CNS among students indicates the need to improve measures to increase the efectiveness of prevention, therapeutic measures and the formation of a healthy lifestyle.

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Modern practical-oriented approach to professional selection for medical professions among school graduates

Year: 2019, volume 15 Issue: №2 Pages: 338-341
Heading: Health Service Organization Article type: Original article
Authors: Kasimovskaya N.A.
Organization: I.M. Sechenov First Moscow State Medical University
Summary:

Objective: to study efciency of introduction of new instrument of vocational guidance in the feld of medicine — «Pre-Professional Examination» (Practical part), to estimate the current state of readiness for choice of medical profession among school leavers. Material and Methods. In 2017, for the frst time, an organizational experiment on the technology «Objective Structured Clinical Examination» (OSKE) for students of 11 grades of schools in Moscow (n=2703) was conducted and a comparative analysis with the results of obligatory «Pre-Professional Examination» (Practical part) (n=3100 respectively) to assess the practical skills of frst aid, also applied a sociological method to assess the readiness of graduates of secondary general educational organizations to the choice of the medical profession (n=300). Results. As a result of research it is established that at voluntary choice of participation in the practical-oriented examination (organizational experiment) the results are higher (60 points — 35.1±1.4 %), than at obligatory passage of «Pre-Professional Examination» (Practical part) (60 points — 2.1±0.3 %) which determines its importance as a motivational factor in the choice of professions in the feld of medicine. The sociological survey showed that 49±3.1 % of students-graduates of schools have not yet decided on the choice of profession. Conclusion. The efectiveness and signifcance of introducing the «Pre- professional exam» (practical part) as a promising method of strategic planning in government regulation of the formation of human resources for the health care system from school graduates and challengers for medical specialties has been scientifcally proven.

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Actual nutrition and food status of children with alimentary-dependent pathology

Year: 2019, volume 15 Issue: №2 Pages: 333-337
Heading: Hygiene Article type: Original article
Authors: Setko A.G., Mryasova Zh.K., Terekhova E.A., Tyurin A.V.
Organization: Orenburg State Medical University
Summary:

Purpose: to study the actual nutrition and nutritional status of children with nutritional-dependent pathology. Material and Methods. The object of the study was 100 children aged 3–11 years, with a clinical diagnosis of alimentary-dependent pathology (functional dyspepsia (K30) and chronic gastritis (K29.3-K29.5)). Evaluation of the actual nutrition of children was carried out in organized children»s groups questionnaire based on 24-day reproduction of food. Nutritional status was assessed by the Quetelet index, physical development was assessed by somatometric indicators (height, body weight, chest circumference) using centile tables with and harmonious physical development. Results. Child nutrition is characterized by excessive energy value, increased content and imbalance of macro- and micronutrients. At the same time, 12 % of children have excessive nutritional status, 14.8 % have disharmonious physical development due to very low body weight (7.4 %). Conclusion. As a result of the study, data were obtained characterizing the nutrition of children as irrational and inadequate, leading to changes in nutritional status and physical development.

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Control of safety of products intended for children: chemical and analytical support

Year: 2019, volume 15 Issue: №2 Pages: 328-333
Heading: Hygiene Article type: Original article
Authors: Larkina M.V., Goryacheva L.V., Egorchenkova O.E., Feiskhanov M.R.
Organization: Federal Scientifc Center of Hygiene n. a. F. F. Erisman
Summary:

Objective: to develop a method for measuring the concentrations of zinc dimethyldithiocarbamate (cimate) and zinc diethyldithiocarbamate (ethylcymate) in aqueous extracts, which provides control of the level of migration of these substances into the aquatic environment and meets the requirements of TR CU 008 / 2011 «On the safety of toys», based on the gas chromatographic analysis method. Material and Methods. The object of the study included samples of the aqueous extract of rubber latex compositions that form the basis of children»s toys, standard samples of cymate, of ethylcymate, of carbon disulphide. Experimental studies have been carried out to develop a gas chromatographic method using a fame photometric detector, a capillary column and an analysis of the equilibrium vapor- gas phase. Results. It was found out that the quantitative determination of cymate and ethylcymate in aqueous extracts is possible with the combination of chromatography of solutions of carbon disulfde in benzene and automatic dosing of the vapor phase (carbon disulfde released as a result of acid hydrolysis in the presence of tin chloride (II)). The efciency of the selected conditions of gas chromatographic analysis is shown. The conversion factor K, which characterizes the correction of the values obtained by analyzing the direct input of carbon disulfde in benzene and vapor phase analysis, is calculated. Conclusion. To control the safety of products intended for children, developed a method of measuring concentrations of cymate and ethylcymate the aqueous extracts of rubber latex products. The method is designed in the determination: 0,1 mg / dm3.

Principles of the program of enhanced recovery of patients after radical prostatectomy

Year: 2019, volume 15 Issue: №2 Pages: 324-327
Heading: Urology Article type: Review
Authors: Pavlov V.N., Tarasenko A.I., Korelov Yu.A., Maksimova S.Yu., Khotko D.N., Khotko A.I.
Organization: Bashkir State Medical University of the Russian Health Care, I.M. Sechenov First Moscow State Medical University, Saratov State Medical University
Summary:

Analysis of statistical data on cancer incidence shows a high prevalence of such diseases as prostate cancer. The existing methods of treatment of this pathology are efective, but the question of reducing the surgical stress of patients who underwent surgery, reducing the number of complications, early mobilization and early recovery remains relevant. The presented literary review reveals the provisions proposed in the XX century, multimodal strategy «Fast track sur-gery», revealing the tactics of surgical patients throughout the perioperative period. The application of this protocol shows its efectiveness in reducing the duration of hospitalization and early rehabilitation of the considered group of patients.

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Principles of the program of enhanced recovery of patients after radical prostatectomy

Year: 2019, volume 15 Issue: №2 Pages: 324-327
Heading: Urology Article type: Review
Authors: Pavlov V.N., Tarasenko A.I., Korelov Yu.A., Maksimova S.Yu., Khotko D.N., Khotko A.I.
Organization: Bashkir State Medical University of the Russian Health Care, I.M. Sechenov First Moscow State Medical University, Saratov State Medical University
Summary:

Analysis of statistical data on cancer incidence shows a high prevalence of such diseases as prostate cancer. The existing methods of treatment of this pathology are efective, but the question of reducing the surgical stress of patients who underwent surgery, reducing the number of complications, early mobilization and early recovery remains relevant. The presented literary review reveals the provisions proposed in the XX century, multimodal strategy «Fast track sur-gery», revealing the tactics of surgical patients throughout the perioperative period. The application of this protocol shows its efectiveness in reducing the duration of hospitalization and early rehabilitation of the considered group of patients.

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